Poly(glycerol adipate-co-Ω-pentadecalactone) Spray-dried microparticles as sustained release carriers for pulmonary delivery

Pharmaceutical Research

Volumn 28, Issue 9, 2011, Pages 2086-2097

  Tawfeek, Hesham ^a,b   Khidr, Sayed ^b   Samy, Eman ^b   Ahmed, Sayed ^b   Murphy, Mark ^a   Mohammed, Afzaal ^c   Shabir, Anjum ^c   Hutcheon, Gillian ^a   Saleem, Imran ^a  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b Assiut University   (Egypt)

^c ASTON UNIVERSITY   (United Kingdom)

Author keywords

Dry powder inhalation; Microparticles; Polyester polymers; Pulmonary drug delivery; Sustained drug release

Indexed keywords

ARGININE; DRUG CARRIER; FLUORESCEIN SODIUM; LEUCINE; POLY(GLYCEROL ADIPATE CO OMEGA PENTADECALACTONE); POLYESTER; UNCLASSIFIED DRUG;

AEROSOL; AMINO ACID COMPOSITION; ARTICLE; BIODEGRADABILITY; BRONCHUS MUCOSA; CONTROLLED STUDY; DISPERSION; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; EPITHELIUM CELL; HUMAN; HUMAN CELL; LUNG TOXICITY; MOLECULAR WEIGHT; PARTICLE SIZE; POWDER; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PULMONARY DELIVERY; SPRAY DRYING; SUSTAINED DRUG RELEASE;

AEROSOLS; CELL LINE; CELL SURVIVAL; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG COMPOUNDING; EPITHELIAL CELLS; HUMANS; LUNG; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; MOLECULAR STRUCTURE; PARTICLE SIZE; POLYESTERS; POWDERS; SOLUBILITY; SURFACE PROPERTIES; TISSUE DISTRIBUTION;

EID: 80054737338     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0433-6     Document Type: Article

References (48)

1. Namekawa S, Uyama H, Kobayashi S. Enzymatic synthesis of polyesters from lactones, dicarboxylic acid divinyl esters, and glycols through combination of ring-opening polymerization and polycondensation. Biomacromolecules. 2000;1(3):335-8.
2. Kobayashi S. Enzymatic polymerisation: a new method of polymer synthesis. J Polym Sci. 1999;37(16):3041-56.
3. Namekawa S, Suda S, Uyama H, Kobayashi S. Lipase-catalyzed ring-opening polymerization of lactones to polyesters and its mechanistic aspects. Int J Biol Macromolecules. 1999;25(1-3):145-51. (Pubitemid 29301993)
4. Kallinteri P, Higgins S, Hutcheon GA, St Pourcain CB, Garnett MC. Novel functionalized biodegradable polymers for nanoparticle drug delivery systems. Biomacromolecules. 2005;6(4):1885-94. (Pubitemid 41052181)
5. Puri S, Kallinteri P, Higgins S, Hutcheon GA, Garnett MC. Drug incorporation and release of water soluble drugs from novel functionalised poly (glycerol adipate) nanoparticles. J Control Release. 2008;125(1):59-67. (Pubitemid 350198677)
6. Thompson CJ, Hansford D, Higgins S, Rostron C, Hutcheon GA, Munday DL. Evaluation of ibuprofen-loaded microspheres prepared from novel copolyesters. Int J Pharm. 2007;329(1-2):53-61. (Pubitemid 44937523)
7. Gaskell EE, Hobbs G, Rostron C, Hutcheon GA. Encapsulation and release of alpha-chymotrypsin from poly (glycerol adipate-coomega-pentadecalactone) microparticles. J Microencapsul. 2008;25(3):187-95.
8. Ungaro F, Bianca R, Giovino C, Miro A, Sorrentino R, Quaglia F, et al. Insulin-loaded PLGA/cyclodextrin large porous particles with improved aerosolization properties: in vivo deposition and hypoglycaemic activity after delivery to rat lungs. J Control Release. 2009;135(1):25-34.
9. Lee ES, Kwon MJ, Na K, Bae JH. Protein release behavior from porous microparticle with lysozyme/hyaluronate ionic complex. Colloids Surf B Biointerfaces. 2007;55(1):125-30. (Pubitemid 46216069)
10. Newhouseand MT, Corkery KJ. Aerosols for systemic delivery of macromolecules. Respir Care Clin N Am. 2001;7(2):261-75. (Pubitemid 33077196)
11. Westerman EM, De Boer AH, Le Brun PPH, Touw DJ, Roldaan AC, Frijlink HW, et al. Dry powder inhalation of colistin in cystic fibrosis patients: a single dose pilot study. J Cyst Fibros. 2007;6(4):284-92. (Pubitemid 46971893)
12. Rabbani NR, Seville PC. The influence of formulation components on the aerosolisation properties of spray-dried powders. J Control Release. 2005;110(1):130-40. (Pubitemid 41713937)
13. Seville PC, Kellaway IW, Birchall JC. Preparation of dry powder dispersions for non-viral gene delivery by freeze-drying and spraydrying. J Gene Med. 2002;4(4):428-37. (Pubitemid 40277180)
14. Zeng XM, Martin GP, Marriott C. The controlled delivery of drugs to the lung. Int J Pharm. 1995;124(2):149-64.
15. Hardyand JG, Chadwick TS. Sustained release drug delivery to the lungs - An option for the future. Clin Pharmacokinet. 2000;39(4):1-4. (Pubitemid 30468201)
16. Cook RO, Pannu RK, Kellaway IW. Novel sustained release microspheres for pulmonary drug delivery. J Control Release. 2005;104(1):79-90. (Pubitemid 40615237)
17. Kawashima Y, Yamamoto H, Takeuchi H, Fujioka S, Hino T. Pulmonary delivery of insulin with nebulized DL-lactide/glycolide copolymer (PLGA) nanospheres to prolong hypoglycemic effect. J Control Release. 1999;62(1-2):279-87. (Pubitemid 29486508)
18. Edwards DA, Hanes J, Caponetti G, Hrkach J, BenJebria A, Eskew ML, et al. Large porous particles for pulmonary drug delivery. Science. 1997;276(5320):1868-71. (Pubitemid 27443665)
19. Hanes J, Edwards DA, Evora C, Langer R. Particles incorporating surfactants for pulmonary drug delivery, Massachusetts Institute of Technology and the Penn State Research Foundation, 1999;303-4.
20. Learoyd TP, Burrows JL, French E, Seville PC. Sustained delivery of salbutamol and beclometasone from spray-dried double emulsions. J Microencapsul. 2010;27(2):162-70.
21. Fiegel J, Fu H, Hanes J. Poly (ether-anhydride) dry powder aerosols for sustained drug delivery in the lungs. J Control Release. 2004;96(3):411-23. (Pubitemid 38553920)
22. van de Weert M, Hennink WE, Jiskoot W. Protein instability in poly (lactic-co-glycolic acid) microparticles. Pharm Res. 2000;17(10):1159-67.
23. Batycky RP, Hanes J, Langer R, Edwards DA. A theoretical model of erosion and macromolecular drug release from biodegrading microspheres. J Pharm Sci. 1997;86(12):1464-77. (Pubitemid 28018331)
24. Tawfeek HM, Khidr SH, Samy EM, Ahmed SM, Hutcheon GA, Saleem I. PGA-co-PDL as a novel carrier for pulmonary drug delivery. 7th world meeting of pharmaceutic, biopharmaceutics and industrial pharmacy, Malta. 2010.
25. He P, Davis SS, Illum L. Sustained release chitosan microspheres prepared by novel spray drying methods. J Microencapsul. 1999;16(3):343-55. (Pubitemid 29191817)
26. Li WI, Perzl M, Heyder J, Langer R, Brain JD, Englmeier KH, et al. Aerodynamics and aerosol particle deaggregation phenomena in model oral-pharyngeal cavities. J Aerosol Sci. 1996;27(8):1269-86. (Pubitemid 26388438)
27. Li HY, Seville PC, Williamson IJ, Birchall JC. The use of amino acids to enhance the aerosolisation of spary dried powders for pulmonary gene therapy. J Gene Med. 2005;7(3):1035-43. (Pubitemid 41195065)
28. Thompson CJ, Hansford D, Higgins S, Hutcheon GA, Rostron C, Munday DL. Enzymatic synthesis and evaluation of new novel omega-pentadecalactone polymers for the production of biodegradable microspheres. J Microencapsul. 2006;23(2):213-26. (Pubitemid 43840672)
29. Grenha A, Seijo B, Remuñán-López C. Microencapsulated chitosan nanoparticles for lung protein delivery. Eur J Pharm Sci. 2005;25(4-5):427-37. (Pubitemid 40853870)
30. Li X, Guo Q, Zheng X, Kong X, Shi S, Chen L, et al. Preparation of honokiol-loaded chitosan microparticles via spray-drying method intended for pulmonary delivery. Drug Deliv. 2009;16(3):160-6.
31. Learoyd TP, Burrows JL, French E, Seville PC. Chitosan-based spray-dried respirable powders for sustained delivery of terbutaline sulfate. Eur J Pharm Biopharm. 2008;68(2):224-34.
32. Bosquillon C, Préat V, Vanbever R. Pulmonary delivery of growth hormone using dry powders and visualization of its local fate in rats. J Control Release. 2004;96(2):233-44. (Pubitemid 38481506)
33. Feddah MR, Brown KF, Gipps EM, Davies NM. In-vitro characterisation of metered dose inhaler versus dry powder inhaler glucocorticoid products: Influence of inspiratory flow rates. J Pharm Pharm Sci. 2000;3(3):317-24.
34. Mittal G, Sahana DK, Bhardwaj V, Kumar M. Estradiol loaded PLGA nanoparticles for oral administration: effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo. J Control Release. 2007;119(1):77-85. (Pubitemid 46561546)
35. Ståhl K, Claesson M, Lilliehorn P, Lindén H, Bäckström K. The effect of process variables on the degradation and physical properties of spray dried insulin intended for inhalation. Int J Pharm. 2002;233(1-2):227-37. (Pubitemid 34230435)
36. Chew NYK, Tang P, Chan HK, Raper JA. How much particle surface corrugation is sufficient to improve aerosol performance of powders? Pharm Res. 2005;22(1):148-52. (Pubitemid 40558157)
37. Uchida T, Yoshida K, Nakada Y, Nagareyan N, Konishi Y, Nakai A, et al. Preparation and characterization of polylactic acid microspheres containing water-soluble anesthetics with small molecular weight. Chem Pharm Bull Tokyo. 1997;45(3):513-7. (Pubitemid 27150216)
38. Corrigan OI. Thermal-analysis of spray-dried products. Thermochim Acta. 1995;24(8):245-58.
39. Neumann BS. In: Bean HS, Beckett AH, Carless JE, editors. Advances in pharmaceutical sciences. London: Academic; 1967. p. 181-221.
40. Seville PC, Learoyd TP, Li HY, Williamson IJ, Birchall JC. Amino acid-modified spray-dried powders with enhanced aerosolisation properties for pulmonary drug delivery. Powder Tech. 2007;178(1):40-50. (Pubitemid 47247802)
41. Alder M, Unger M, Lee G. Surface composition of spray dried particles of bovine serum albumin/trehalose/surfactant. Pharm Res. 2000;17(7):863-70. (Pubitemid 30666969)
42. Najafabadi AR, Gilani K, Barghi M, Rafiee-Tehrani M. The effect of vehicle on physical properties and aerosolisation behaviour of disodium cromoglycate microparticles spray dried alone or with L-leucine. Int J Pharm. 2004;285(1-2):97-108. (Pubitemid 39361540)
43. Chew NYK, Shekunov BY, Tong HHY, Chow AHL, Savage C, Wu J, et al. Effect of amino acids on the dispersion of disodium cromoglycate powders. J Pharm Sci. 2005;94(10):2289-300. (Pubitemid 41665288)
44. Glinski J, Chavepeyer G, Platten JK. Surface properties of aqueous solutions of L-leucine. Biophys Chem. 2000;84(2):99-103. (Pubitemid 30168951)
45. Maa YF, Nguyen PAT, Hsu SW. Spray-drying of air-liquid interface sensitive recombinant human growth hormone. J Pharm Sci. 1998;87(2):152-9. (Pubitemid 28081321)
46. Thompson CJ, Hansford D, Munday DL, Higgins S, Rostron C, Hutcheon GA. Synthesis and evaluation of novel polyesteribuprofen conjugates for modified drug release. Drug Dev Ind Pharm. 2008;34(8):877-84.
47. Tawfeek HM. Evaluation of novel biodegradable polyesters for pulomnary protein delivery, Faculty of Pharmacy, Vol. Doctor of Philosophy, Assuit University, Assuit, Egypt, 2011.
48. Canal-Raffin M, L'Azou B, Martinez B, Sellier E, Fawaz F, Robinson P et al. Physicochemical characteristics and bronchial epithelial cell cytotoxicity of Folpan 80 WG (R) and Myco 500 (R), two commercial forms of folpet. Part Fibre Toxicol. 2007;4(8):1743-8977-4-8.