Synthesis and evaluation of novel polyester-ibuprofen conjugates for modified drug release

Drug Development and Industrial Pharmacy

Volumn 34, Issue 8, 2008, Pages 877-884

  Thompson, C J ^a   Hansford, D ^a   Munday, D L ^a   Higgins, S ^b   Rostron, C ^b   Hutcheon, G A ^b  

^a ROBERT GORDON UNIVERSITY   (United Kingdom)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

Author keywords

Conjugation; Ibuprofen; Modified release; Polyesters; Polymer degradation

Indexed keywords

HYDROXYL GROUP; IBUPROFEN; POLY(GLYCEROL ADIPATE CO OMEGA PENTADECALACTONE); POLYESTER; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED DRUG RELEASE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG CONJUGATION; DRUG STRUCTURE; DRUG SYNTHESIS; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFRARED SPECTROSCOPY; MELTING POINT; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ULTRAVIOLET RADIATION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DELAYED-ACTION PREPARATIONS; IBUPROFEN; MAGNETIC RESONANCE SPECTROSCOPY; POLYESTERS; SPECTROPHOTOMETRY, INFRARED;

EID: 49449098794     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040801929075     Document Type: Article

References (20)

1. Bodmeier, R., & Chen, H. (1989). Preparation and characterization of microspheres containing the anti-inflammatory agents, indomethacin, ibuprofen, and ketoprofen. J. Control. Release, 10, 167-175.
2. Duncan, R. (2003). The dawning era of polymer therapeutics. Nat. Rev., 2, 347-360.
3. Edlund, U., & Albertsson, A.-C. (2002). Degradable polymer microspheres for controlled drug delivery. Adv. Polym. Sci., 157, 67-112.
4. Engelberg, I., & Kohn, J. (1991). Physico-mechanical properties of degradable polymers used in medical applications: A comparative study. Biomaterials, 12, 292-303.
5. Flandroy, P. M. J., Grandfils, C., & Jerome, R. (1993). Clinical applications of microspheres in embolization and chemoembolization: Comprehensive review and perspectives. In A. Rolland (Ed.), Pharmaceutical particulate carriers: Therapeutic applications (pp. 321-366). New York: Marcel Dekker Inc.
6. Fu, Y.-J., Shyu, S.-S., Su, F.-H., & Yu, P.-C. (2002). Development of biodegradable co-poly(D,L-lactic/glycolic acid) microspheres for the controlled release of 5-FU by the spray drying method. Colloids Surf., B, 25(4), 269-279.
7. Gopferich, A. (1996). Mechanisms of polymer degradation and erosion. Biomaterials, 17, 103-114.
8. Jain, J. A. (2000). The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials, 21, 2475-2490.
9. Khandare, J., & Minko, T. (2006). Polymer-drug conjugates: Progress in polymeric prodrugs. Prog. Polym. Sci., 31, 359-397.
10. Nam, Y. S., & Park, T. G. (1999). Protein loaded biodegradable microspheres based on PLGA-protein bioconjugates. J. Microencapsulation, 16(5), 625-637.
11. Oh, J. E., Nam, Y. S., Lee, K. H., & Park, T. G. (1999). Conjugation of drug to poly(D,L-lactic-co-glycolic acid) for controlled release from biodegradable microspheres. J. Control. Release, 57, 269-280.
12. Park, T. G. (1995). Degradation of poly(lactic-co-glycolic acid) microspheres: Effect of copolymer composition. Biomaterials, 16, 1123-1130.
13. Perumal, D., Dangor, C. M., Alcock, R. S., Hurbans, N., & Moopanar, K. R. (1999). Effect of formulation variables on in vitro drug release and micrometric properties of modified release ibuprofen microspheres. J. Microencapsulation, 16, 475-487.
14. Rimoli, M. G., Avallone, L., de Caprariis, P., Galeone, A., Forni, F., & Vandelli, M. A. (1999). Synthesis and characterisation of poly(D,L-lactic acid)-idoxuridine conjugate. J. Control. Release, 58, 61-68.
15. Thompson, C. J., Hansford, D., Higgins, S., Hutcheon, G. A., Rostron, C., & Munday, D. L. (2006). Enzymatic synthesis and evaluation of new novel ω-pentadecalactone polymers for the production of biodegradable microspheres. J. Microencapsulation, 23(2), 213-226.
16. Thompson, C. J., Hansford, D., Higgins, S., Rostron, C., Hutcheon, G. A., & Munday, D. L. (2007). Evaluation of ibuprofen-loaded microspheres prepared from novel copolyesters. Int. J. Pharm., 329, 53-61.
17. Tice, T. R., & Cowsar, D. R. (1984). Biodegradable controlled-release parenteral systems. Pharm. Technol., 11, 26-36.
18. Ustariz-Peyret, C., Coudane, J., Vert, M., Kaltsatos, V., & Boisrame, B. (2000). Labile conjugation of a hydrophilic drug to PLA oligomers to modify a drug delivery system: Cephradin in a PLAGA matrix. J. Microencapsulation, 17(5), 615-624.
19. Yoo, H. S., Lee, K. H., Oh, J. E., & Park, T. G. (2000). In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin-PLGA conjugates. J. Controlled Release, 68, 419-431.
20. Zhu, K. J., Li, Y., Jiang, H. L., Yasuda, H., Ichimaru, A., Yamamoto, K., Lecomte, P., & Jerome, R. (2005). Preparation, characterization and in vitro release properties of ibuprofen-loaded microspheres based on polylactide, poly(ε-caprolactone) and their copolymers. J. Microencapsulation, 22, 25-36.