Preparation and characterization of polylactic acid microspheres containing water-soluble anesthetics with small molecular weight

Chemical and Pharmaceutical Bulletin

Volumn 45, Issue 3, 1997, Pages 513-517

  Uchida, Takahiro ^a   Yoshida, Kazushi ^b   Nakada, Yoichi ^c   Nagareya, Noriko ^a   Konishi, Yuriko ^a   Nakai, Aki ^a   Nishikata, Mayumi ^a   Matsuyama, Kenji ^a  

^a MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

^b Teikoku Zouki Pharmaceutics   (Japan)

^c TORAY INDUSTRIES INC   (Japan)

Author keywords

anesthetic; microsphere; polylactic acid; solvent evaporation method; sustained release; w o w emulsion

Indexed keywords

ANESTHETIC AGENT; CINCHOCAINE; LIDOCAINE; MICROSPHERE; PENTOBARBITAL; PHENOBARBITAL; POLYLACTIC ACID; PROCAINE; SODIUM CHLORIDE;

ANALGESIA; ARTICLE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; MOLECULAR WEIGHT; SUSTAINED RELEASE PREPARATION;

EID: 0030974850     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.45.513     Document Type: Article

References (14)

1. Mortada M., Pharmazie, 37, 427-429 (1982).
2. Uchida T., Kawata M., Goto S., J. Pharmacobio-Dyn., 9, 631-637 (1986).
3. Jalsenjak I., Kondo T., J. Pharm. Sci., 70, 456-457 (1981).
4. Deasy P. B., Brophy M. R., Ecanow B., Joy M., J. Pharm. Pharmacol., 32, 15-20 (1980).
5. Nixon J. R., Maleka M. R., J. Microencapsulation, 1, 53-64 (1984).
6. Bodmeier R., McGinity J. W., Pharm. Res., 4, 465-469 (1986).
7. Ogawa Y., Yamamoto M., Takada S., Okada H., Shimamoto T., Chem. Pharm. Bull., 36, 1095-1103 (1988).
8. Okada H., Heya T., Ogawa Y., Toguchi H., Shimamoto T., Pharm. Res., 8, 584-587 (1991).
9. Uchida T., Martin S., Foster T. P., Wardley R. C., Grimm S., Pharm. Res., 11, 1009-1015 (1994).
10. Uchida T., Goto S., Foster T. P., J. Pharm. Pharmacol., 47, 556-560 (1995).
11. Uchida T., Yoshida K., Goto S., J. Microencapsulation, 13, 219-228 (1996).
12. Uchida T., Yoshida K., Ninomiya A., Goto S., Chem. Pharm. Bull., 43, 1569-1573 (1995).
13. Jalil R., Nixon J. R., J. Microencapsulation, 6, 473-484 (1989).
14. Heya T., Okada H., Ogawa Y., Toguchi H., J. Pharm. Sci., 83, 636-640 (1994).