Effects of acute and chronic hypoxia on the radiosensitivity of gastric and esophageal cancer cells

Anticancer Research

Volumn 31, Issue 10, 2011, Pages 3369-3375

  Kato, Yukihiro ^a   Yashiro, Masakazu ^a   Fuyuhiro, Yuhiko ^a   Kashiwagi, Shinichiro ^a   Matsuoka, Junko ^a   Hirakawa, Joshiki ^a   Noda, Satoru ^a   Aomatsu, Naoki ^a   Hasegawa, Tsuyoshi ^a   Matsuzaki, Taro ^a   Sawada, Tetsuji ^a   Ohira, Masaichi ^a   Hirakawa, Kosei ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cell cycle; Esophageal cancer; Gastric cancer; Hypoxia; Radiation sensitivity; Reoxygenation

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; CELL PROTEIN; MESSENGER RNA; PROTEIN P21; PROTEIN P53; RAD51 PROTEIN; RB1 PROTEIN; UNCLASSIFIED DRUG;

ACUTE CELL HYPOXIA; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL HYPOXIA; CHRONIC CELL HYPOXIA; COLONY FORMATION; CONTROLLED STUDY; ESOPHAGUS CANCER; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; REOXYGENATION; STOMACH CANCER;

CELL HYPOXIA; CELL LINE, TUMOR; ESOPHAGEAL NEOPLASMS; G0 PHASE; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; OXYGEN; RADIATION TOLERANCE; STOMACH NEOPLASMS; TUMOR STEM CELL ASSAY; X-RAYS;

EID: 80054724189     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Roder DM: The epidemiology of gastric cancer. Gastric Cancer 5: 5-11, 2002.
2. Enzinger PC and Mayer RJ: Esophageal cancer. N Engl J Med 349(23): 2241-22, 2003.
3. Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, Stemmermann GN, Haller DG, Ajani JA, Gunderson LL, Jessup JM and Martenson JA: Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. New Engl J Med 345(10): 725-730, 2001.
4. Xiao ZF, Yang ZY, Miao YJ, Wang LH, Yin WB, Gu XZ, Zhang DC, Sun KL, Chen GY and He J: Influence of number of metastatic lymph nodes on survival of curative resected thoracic esophageal cancer patients and value of radiotherapy: report of 549 cases. Int J Radiat Oncol Biol Phys 62(7): 82-90, 2005.
5. Driessen A, Landuyt W, Pastorekova S, Moons J, Goethals L, Haustermans K, Nafteux P, Penninckx F, Geboes K, Lerut T and Ectors N: Expression of carbonic anhydrase IX (CA IX), a hypoxia-related protein, rather than vascular-endothelial growth factor (VEGF), a pro-angiogenic factor, correlates with an extremely poor prognosis in esophageal and gastric adenocarcinomas. Ann Surg 243(3): 334-340, 2006. (Pubitemid 43327764)
6. Mayer A, Hockel M, Wree A, Leo C, Horn LC and Vaupel P: Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia. Cancer Res 68(12): 4719-4726, 2008.
7. Vaupel P, Mayer A, Bliest S and Hockel M: Oxygenation gain factor: a novel parameter characterizing the association between hemoglobin level and the oxygenation status of breast cancers. Cancer Res 63(22): 7634-7637, 2003. (Pubitemid 37466687)
8. Rockwell S: Oxygen delivery: implications for the biology and therapy of solid tumors. Oncol Res 9(6-7): 383-390, 1997.
9. Vaupel P: The role of hypoxia-induced factors in tumor progression. Oncologist 9(Suppl 5): 10-17, 2004.
10. Semenza GL: HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med 8: S62-67, 2002.
11. Subarsky P and Hill RP: The hypoxic tumour microenvironment and metastatic progression. Clin Exp Metastasis 20(3): 237-250, 2003. (Pubitemid 36513228)
12. Hockel M and Vaupel P: Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 93(4): 266-276, 2001. (Pubitemid 32219813)
13. Santore MT, McClintock DS, Lee VY, Budinger GR and Chandel NS: Anoxia-induced apoptosis occurs through a mitochondria-dependent pathway in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 282(4): L727-734, 2002. (Pubitemid 34665588)
14. Saitoh Y, Ouchida R and Miwa N: Bcl-2 prevents hypoxia/reoxygenation- induced cell death through suppressed generation of reactive oxygen species and upregulation of Bcl-2 proteins. J Cell Biochem 90(5): 914-924, 2003. (Pubitemid 37467107)
15. Yook YJ, Seo YJ, Kang HJ, Ko SH, Shin HY, Lee JJ, Jeong G and Ahn HS: Induction of hypoxia-inducible factor-1alpha inhibits drug-induced apoptosis in the human leukemic cell line HL-60. Korean J Hematol 45(3): 158-163, 2010.
16. Kim JY, Kim YJ, Lee S and Park JH: The critical role of ERK in death resistance and invasiveness of hypoxia-selected glioblastoma cells. BMC Cancer 9: 27, 2009.
17. Song MS, Park YK, Lee JH and Park K: Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-epsilon/ERK/AP-1 signaling cascade. Cancer Res 61(22): 8322-8330, 2001.
18. Wilson GD: Cell kinetics. Clin Oncol (R Coll Radiol) 19(6): 370-384, 2007.
19. Qiu H, Yashiro M, Shinto O, Matsuzaki T and Hirakawa K: DNA methyltransferase inhibitor 5-aza-CdR enhances the radiosensitivity of gastric cancer cells. Cancer Sci 100(1): 181188, 2009.
20. Petersen L, Hasvold G, Lukas J, Bartek J and Syljuasen RG: p53-dependent G(1) arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionizing radiation and Chk1 inhibitors. Cell Prolif 43(4): 365-371, 2010.
21. Kato Y, Yashiro M, Noda S, Tendo M, Kashiwagi S, Doi Y, Nishii T, Matsuoka J, Fuyuhiro Y, Shinto O, Sawada T, Ohira M and Hirakawa K: Establishment and characterization of a new hypoxia-resistant cancer cell line, OCUM-12/Hypo, derived from a scirrhous gastric carcinoma. Br J Cancer 102(5): 898-907, 2010.
22. Pfaffl MW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29(9): e45, 2001.
23. Giaccia AJ: Hypoxic stress proteins: Survival of the fittest. Semin Radiat Oncol 6(1): 46-58, 1996.
24. Amellem O, Loffler M and Pettersen EO: Regulation of cell proliferation under extreme and moderate hypoxia: the role of pyrimidine (deoxy)nucleotides. Br J Cancer 70(5): 857-866, 1994. (Pubitemid 24331077)
25. Haroon ZA, Raleigh JA, Greenberg CS and Dewhirst MW: Early wound healing exhibits cytokine surge without evidence of hypoxia. Ann Surg 231(1): 137-147, 2000. (Pubitemid 30043951)
26. Riva C, Chauvin C, Pison C and Leverve X: Cellular physiology and molecular events in hypoxia-induced apoptosis. Anticancer Res 18(6B): 4729-4736, 1998. (Pubitemid 29042052)
27. Helleday T, Lo J, van Gent DC and Engelward BP: DNA double-strand break repair: from mechanistic understanding to cancer treatment. DNA Repair (Amst) 6(7): 923-935, 2007. (Pubitemid 46880473)
28. Rodrigue A, Lafrance M, Gauthier MC, McDonald D, Hendzel M, West SC, Jasin M and Masson JY: Interplay between human DNA repair proteins at a unique double-strand break in vivo. Embo J 25(1): 222-231, 2006. (Pubitemid 43077310)
29. Fan R, Kumaravel TS, Jalali F, Marrano P, Squire JA and Bristow RG: Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression. Cancer Res 64(23): 8526-8533, 2004. (Pubitemid 39552064)
30. Bindra RS and Glazer PM: Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia. Oncogene 26(14): 2048-2057, 2007. (Pubitemid 46514738)
31. Bindra RS, Gibson SL, Meng A, Westermark U, Jasin M, Pierce AJ, Bristow RG, Classon MK and Glazer PM: Hypoxia-induced down-regulation of BRCA1 expression by E2Fs. Cancer Res 65(24): 11597-11604, 2005. (Pubitemid 41821719)
32. Rothkamm K, Kruger I, Thompson LH and Lobrich M: Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol Cell Biol 23(16): 5706-5715, 2003. (Pubitemid 36951334)
33. Barnas C, Martel-Planche G, Furukawa Y, Hollstein M, Montesano R and Hainaut P: Inactivation of the p53 protein in cell lines derived from human esophageal cancers. Int J Cancer 71(1): 79-87, 1997. (Pubitemid 27158413)
34. Mizuno S, Kadowaki M, Demura Y, Ameshima S, Miyamori I and Ishizaki T: p42/44 Mitogen-activated protein kinase regulated by p53 and nitric oxide in human pulmonary arterial smooth muscle cells. Am J Respir Cell Mol Biol 31(2): 184-192, 2004. (Pubitemid 39095447)
35. O'Reilly MA, Staversky RJ, Watkins RH, Reed CK, de Mesy Jensen KL, Finkelstein JN and Keng PC: The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress. Am J Respir Cell Mol Biol 24(6): 703-710, 2001. (Pubitemid 32550592)
36. CIP1/WAF1 gene in normal diploid human fibroblasts. Science 277(5327): 831-834, 1997.
37. Datto MB, Li Y, Panus JF, Howe DJ, Xiong Y and Wang XF: Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc Natl Acad Sci USA 92(12): 5545-5549, 1995.
38. Ohnishi T, Taki T, Hiraga S, Arita N and Morita T: In vitro and in vivo potentiation of radiosensitivity of malignant gliomas by antisense inhibition of the RAD51 gene. Biochem Biophys Res Commun 245(2): 319-324, 1998. (Pubitemid 28418498)