Non-steroidal dissociated glucocorticoid agonists: Indoles as A-ring mimetics and function-regulating pharmacophores

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 22, 2011, Pages 6842-6851

  Betageri, Raj ^a   Gilmore, Thomas ^a   Kuzmich, Daniel ^a   Kirrane, Thomas M ^a   Bentzien, Jörg ^a   Wiedenmayer, Dieter ^a   Bekkali, Younes ^a   Regan, John ^a   Berry, Angela ^a   Latli, Bachir ^a   Kukulka, Alison J ^a   Fadra, Tazmeen N ^a   Nelson, Richard M ^a   Goldrick, Susan ^a   Zuvela Jelaska, Ljiljana ^a   Souza, Don ^a   Pelletier, Josephine ^a   Dinallo, Roger ^a   Panzenbeck, Mark ^a   Torcellini, Carol ^a   Lee, Heewon ^a   Pack, Edward ^a   Harcken, Christian ^a   Nabozny, Gerald ^a   Thomson, David S ^a   more..

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Dissociated activity; Function regulating pharmacophore; Non steroidal glucocorticoid agonist

Indexed keywords

AROMATASE; DEXAMETHASONE; FATTY ACID; GLUCOCORTICOID RECEPTOR; HORMONE RECEPTOR STIMULATING AGENT; INDOLE DERIVATIVE; INSULIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NONSTEROIDAL GLUCOCORTICOID RECEPTOR AGONIST; PREDNISOLONE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BODY FAT; CHRONIC ARTHRITIS; CONTROLLED STUDY; DISEASE COURSE; DISSOCIATION; DRUG EFFICACY; DRUG SELECTIVITY; ENZYME ASSAY; FATTY ACID BLOOD LEVEL; IN VITRO STUDY; INHIBITION KINETICS; INSULIN BLOOD LEVEL; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; PHARMACOPHORE; RAT; STRUCTURE ACTIVITY RELATION; TRANSACTIVATION; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; GLUCOCORTICOIDS; HELA CELLS; HUMANS; INDOLES; MICE; MODELS, MOLECULAR; RECEPTORS, GLUCOCORTICOID; STRUCTURE-ACTIVITY RELATIONSHIP;

MOUSE MAMMARY TUMOR VIRUS;

EID: 80054719120     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.018     Document Type: Article

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