Tetrahydroquinoline glucocorticoid receptor agonists: Discovery of a 3-hydroxyl for improving receptor selectivity

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 168-171

  Roach, Steven L ^a   Higuchi, Robert I ^a   Hudson, Andrew R ^a   Adams, Mark E ^a   Syka, Peter M ^a   Mais, Dale E ^a   Miner, Jeffrey N ^a   Marschke, Keith B ^a   Zhi, Lin ^a  

^a LIGAND PHARMACEUTICALS INC   (United States)

Author keywords

Glucocorticoid; Non steroidal; Tetrahydroquinoline; Transactivation; Transrepression

Indexed keywords

3 HYDROXYL; GLUCOCORTICOID RECEPTOR; HORMONE RECEPTOR AFFECTING AGENT; HYDROXYL GROUP; INDOLE; INTERLEUKIN 6; TETRAHYDROQUINOLINE GLUCOCORTICOID RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

DRUG EVALUATION, PRECLINICAL; PROTEIN BINDING; QUINOLINES; RECEPTORS, GLUCOCORTICOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650510149     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.047     Document Type: Article

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