The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 23, 2008, Pages 6097-6099

  Madauss, Kevin P ^a   Bledsoe, Randy K ^a   Mclay, Iain ^a   Stewart, Eugene L ^a   Uings, Iain J ^b   Weingarten, Gordon ^b   Williams, Shawn P ^a  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Aminopyrazol; Benzamides; Crystal structure; Glucocorticoid receptor

Indexed keywords

AMINOPYRAZOLE 2,6 DICHLORO N ETHYLBENZAMIDE; DEXAMETHASONE; FLUTICASONE FUROATE; GLUCOCORTICOID RECEPTOR; HORMONE RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; HUMAN; HUMAN CELL; HYDROGEN BOND; LIGAND BINDING; X RAY CRYSTALLOGRAPHY;

BENZAMIDES; CRYSTALLOGRAPHY, X-RAY; DEXAMETHASONE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PYRAZOLES; RECEPTORS, GLUCOCORTICOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 55749086985     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.021     Document Type: Article

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