Synthesis and structure-activity relationship of novel 6-aryl-1,4- dihydrobenzo[d][1,3]oxazine-2-thiones as progesterone receptor modulators leading to the potent and selective nonsteroidal progesterone receptor agonist tanaproget

Journal of Medicinal Chemistry

Volumn 48, Issue 16, 2005, Pages 5092-5095

  Fensome, Andrew ^a   Bender, Reinhold ^a   Chopra, Rajiv ^a   Cohen, Jeff ^b   Collins, Mark A ^a   Hudak, Valerie ^a   Malakian, Karl ^a   Lockhead, Susan ^c   Olland, Andrea ^a   Svenson, Kristine ^a   Terefenko, Eugene A ^a   Unwalla, Ray J ^a   Wilhelm, James M ^a   Wolfrom, Scott ^a   Zhu, Yuan ^b   Zhang, Zhiming ^b   Zhang, Puwen ^a   Winneker, Richard C ^b   Wrobel, Jay ^a  

^a Chemical and Screening Sciences   (United States)

^b Women's Health Research Institute   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEDROXYPROGESTERONE ACETATE; ORAL CONTRACEPTIVE AGENT; OXAZINE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PROGESTERONE RECEPTOR; PROGESTERONE RECEPTOR MODULATOR; STEROID; TANAPROGET; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; BINDING COMPETITION; CONFERENCE PAPER; CONTRACEPTION; CRYSTAL STRUCTURE; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SAFETY; DRUG SELECTIVITY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; LIGAND BINDING; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ALKALINE PHOSPHATASE; ANIMALS; AREA UNDER CURVE; BENZOXAZINES; BINDING, COMPETITIVE; CELL LINE, TUMOR; CONTRACEPTIVE AGENTS, FEMALE; DECIDUA; FEMALE; HALF-LIFE; HUMANS; LIGANDS; MOLECULAR STRUCTURE; OXAZINES; PROTEIN STRUCTURE, TERTIARY; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PROGESTERONE; STRUCTURE-ACTIVITY RELATIONSHIP; THIONES;

EID: 23444440846     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050358b     Document Type: Conference Paper

References (17)

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