Ligand-receptor interaction between triterpenoids and the 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) enzyme predicts their toxic effects against tumorigenic r/m HM-SFME-1 cells

Journal of Biological Chemistry

Volumn 286, Issue 42, 2011, Pages 36888-36897

  Yamaguchi, Hideaki ^a   Yu, Tao ^b   Noshita, Toshiro ^c   Kidachi, Yumi ^d   Kamiie, Katsuyoshi ^d   Yoshida, Kenji ^a   Akitaya, Tatsuo ^a   Umetsu, Hironori ^e   Ryoyama, Kazuo ^d  

^a MEIJO UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c PREFECTURAL UNIVERSITY OF HIROSHIMA   (Japan)

^d AOMORI UNIVERSITY   (Japan)

^e GIFU SHOTOKU GAKUEN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-TUMOR AGENTS; ANTIPROLIFERATIVE EFFECT; ANTITUMOR EFFECT; CELL-SHRINKAGE; CHEMOPREVENTIVE; CONFOCAL LASER SCANNING; CYTOSKELETAL PROTEINS; CYTOTOXIC EFFECTS; FLUORESCENCE STAINING; GOOD CORRELATIONS; HYDROXYSTEROID DEHYDROGENASE; IN-SILICO; IN-VITRO EVALUATION; INHIBITORY EFFECT; LIGAND-BINDING SITES; LIGAND-RECEPTOR INTERACTIONS; MICROSCOPIC OBSERVATIONS; MORPHOLOGIC CHANGES; OLEANOLIC ACIDS; PARTITION COEFFICIENT; POLAR SURFACE AREAS; TIME-LAPSE MICROSCOPY; TOXIC EFFECT; TRITERPENOIDS; TUMOR CELLS; URSOLIC ACID;

CELL DEATH; CYTOTOXICITY; DEHYDROGENATION; FORECASTING; INDUSTRIAL POISONS; LIGANDS; MAMMALS; PROTEINS; TUMORS;

BIOINFORMATICS;

11BETA HYDROXYSTEROID DEHYDROGENASE 2; CYTOSKELETON PROTEIN; GLYCYRRHETINIC ACID; MYC PROTEIN; OLEANOLIC ACID; RAS PROTEIN; TRITERPENOID; URSOLIC ACID;

ANIMAL CELL; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL STRAIN; CELL STRAIN HM SFME 1; COMPUTER MODEL; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CORRELATION COEFFICIENT; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; EMBRYO; ENZYME INHIBITION; FLUORESCENCE ANALYSIS; IN VITRO STUDY; METASTASIS; MOLECULAR MODEL; MOUSE; MOUSE EMBRYO; NONHUMAN; NUCLEOTIDE SEQUENCE; PARTITION COEFFICIENT; PREDICTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; TUMOR CELL;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; GLYCYRRHETINIC ACID; HUMANS; LIGANDS; MICE; NEOPLASM PROTEINS; NEOPLASMS, EXPERIMENTAL;

EID: 80054699332     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.265900     Document Type: Article

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