Selective cytotoxicity of glycyrrhetinic acid against tumorigenic r/m HM-SFME-1 cells: Potential involvement of H-Ras downregulation

Toxicology Letters

Volumn 192, Issue 3, 2010, Pages 425-430

  Yu, Tao ^a   Yamaguchi, Hideaki ^b   Noshita, Toshiro ^c   Kidachi, Yumi ^d   Umetsu, Hironori ^e   Ryoyama, Kazuo ^d  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b MEIJO UNIVERSITY   (Japan)

^c PREFECTURAL UNIVERSITY OF HIROSHIMA   (Japan)

^d AOMORI UNIVERSITY   (Japan)

^e Laboratory of Food Chemistry   (Japan)

Author keywords

Glycyrrhetinic acid (GA); Glycyrrhizin (GL); Human c Ha ras and mouse c myc cotransfected highly metastatic serum free mouse embryo 1 (r m HM SFME 1); Licorice; Serum free mouse embryo (SFME); Tumor

Indexed keywords

CISPLATIN; CYTARABINE; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; GLYCYRRHETINIC ACID; H RAS PROTEIN; MANUMYCIN; MANUMYCIN A; RAS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CONCENTRATION RESPONSE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; EMBRYO; FLUORESCENCE ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CELL PROLIFERATION; DOWN-REGULATION; DOXORUBICIN; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, RAS; GLYCYRRHETINIC ACID; HUMANS; MICE; NEOPLASMS, EXPERIMENTAL; POLYENES; POLYUNSATURATED ALKAMIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR CELLS, CULTURED;

GLYCYRRHIZA;

EID: 75349101845     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.11.021     Document Type: Article

References (30)

1. Akao T. Distribution of enzymes involved in the metabolism of glycyrrhizin in various organs of rat. Biol. Pharm. Bull. 21 (1998) 1036-1044
2. Armanini D., Fiore C., Mattarello M.J., Bielenberg J., and Palermo M. History of the endocrine effects of licorice. Exp. Clin. Endocrinol. Diab. 110 (2002) 257-261
3. Bijman M.N., van Berkel M.P., van Nieuw Amerongen G.P., and Boven E. Interference with actin dynamics is superior to disturbance of microtubule function in the inhibition of human ovarian cancer cell motility. Biochem. Pharmacol. 76 (2008) 707-716
4. Carmichael J., DeGraff W.G., Gazdar A.F., Minna J.D., and Mitchell J.B. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of radiosensitivity. Cancer Res. 47 (1987) 943-946
5. Chintharlapalli S., Papineni S., Jutooru I., McAlees A., and Safe S. Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor gamma agonists in colon cancer cells. Mol. Cancer Ther. 6 (2007) 1588-1598
6. Di Nicola M., Carlo-Stella C., Mariotti J., Devizzi L., Massimino M., Cabras A., Magni M., Matteucci P., Guidetti A., Gandola L., and Gianni A.M. High response rate and manageable toxicity with an intensive, short-term chemotherapy programme for Burkitt's lymphoma in adults. Br. J. Haematol. 126 (2004) 815-820
7. Frassanito M.A., Cusmai A., Piccoli C., and Dammacco F. Manumycin inhibits farnesyltransferase and induces apoptosis of drug-resistant interleukin 6-producing myeloma cells. Br. J. Haematol. 118 (2002) 157-165
8. Grassi F., Pagani F., Spinelli G., De Angelis L., Cossu G., and Eusebi F. Fusion-independent expression of functional ACH receptors in mouse mesoangioblast stem cells contacting muscle cells. J. Physiol. 560 (2004) 479-489
9. de Groot G., Koops R., Hogendoorn E.A., Goewie C.E., Savelkoul T.J., and van Vloten P. Improvement of selectivity and sensitivity by column switching in the determination of glycyrrhizin and glycyrrhetic acid in human plasma by high-performance liquid chromatography. J. Chromatogr. 456 (1988) 71-81
10. Ham R.G., and McKeehan W.L. Media and growth requirements. Methods Enzymol. 58 (1979) 44-93
11. Isbrucker R.A., and Burdock G.A. Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin. Regul. Toxicol. Pharmacol. 46 (2006) 167-192
12. Kainuma O., Asano T., Hasegawa M., Kenmochi T., Nakagohri T., Tokoro Y., and Isono K. Inhibition of growth and invasive activity of human pancreatic cancer cells by a farnesyltransferase inhibitor, manumycin. Pancreas 15 (1997) 379-383
13. Lee E.J., Petroni G.R., Schiffer C.A., Freter C.E., Johnson J.L., Barcos M., Frizzera G., Bloomfi{ligature}eld C.D., and Peterson B.A. Brief-duration high-intensity chemotherapy for patients with small noncleaved-cell lymphoma or FAB L3 acute lymphocytic leukemia: results of cancer and leukemia group B study 9251. J. Clin. Oncol. 19 (2001) 4014-4022
14. Loo D., Rawson C., Helmrich A., and Barnes D. Serum-free mouse embryo (SFME) cells: growth responses in vitro. J. Cell. Physiol. 139 (1989) 484-491
15. Loo D.T., Fuquay J.I., Rawson C.L., and Barnes D.W. Extended culture of mouse embryo cells without senescence: inhibition by serum. Science 236 (1987) 200-202
16. Martin R., Carvalho J., Ibeas E., Hernandez M., Ruiz-Gutierrez V., and Niet M.L. Acidic triterpenes compromise growth and survival of astrocytoma cell lines by regulating reactive oxygen species accumulation. Cancer Res. 67 (2007) 3741-3751
17. Matano S., Ryoyama K., Nakamura S., Okada G., and Nomura T. Application of the polymerase chain reaction (PCR) to quantify micro-metastasis in an experimental animal. Cancer Lett. 91 (1995) 93-99
18. Mather J.P., and Sato G.H. The use of hormone-supplemented serum-free media in primary cultures. Exp. Cell Res. 124 (1979) 215-221
19. Nihal M., Ahmad N., Mukhtar H., and Wood G.S. Anti-proliferative and proapoptotic effects of (-)-epigallocatechin-3-gallate on human melanoma: possible implications for the chemoprevention of melanoma. Int. J. Cancer 114 (2005) 513-521
20. Nomura T., Matano S., Okada G., Tokuyama H., Hori I., Nakamura S., Kameyama T., and Ryoyama K. Establishment of a metastatic murine cell line carrying the human c-Ha-ras. In Vitro Cell Dev. Biol. 29A (1993) 614-616
21. Rawson C., Cosola-Smith C., and Barnes D. Death of serum-free mouse embryo cells caused by epidermal growth factor deprivation is prevented by cycloheximide, 12-O-tetradecanoylphorbol-13-acetate, or vanadate. Exp. Cell Res. 186 (1990) 177-181
22. Rawson C., Shirahata S., Collodi P., Natsuno T., and Barnes D. Oncogene transformation frequency of nonsenescent SFME cells is increased by c-myc. Oncogene 6 (1991) 487-489
23. Rowland B.D., Bernards R., and Peeper D.S. The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat. Cell Biol. 7 (2005) 1074-1082
24. Saleem M., Maddodi N., Abu Zaid M., Khan N., bin Hafeez B., Asim M., Suh Y., Yun J.M., Setaluri V., and Mukhtar M. Lupeol inhibits growth of highly aggressive human metastatic melanoma cells in vitro and in vivo by inducing apoptosis. Clin. Cancer Res. 14 (2008) 2119-2127
25. Sears K.T., Daino H., and Carey G.B. Reactive oxygen species-dependent destruction of MEK and Akt in manumycin stimulated death of lymphoid tumor and myeloma cell lines. Int. J. Cancer 122 (2008) 1496-1505
26. Seki H., Ohyama K., Sawai S., Mizutani M., Ohnishi T., Sudo H., Akashi T., Aoki T., Saito K., and Muranaka T. Licorice β-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 14204-14209
27. Shibata S. A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice. Yakugaku Zasshi 120 (2000) 849-862
28. Trachootham D., Zhou Y., Zhang H., Demizu Y., Chen Z., Pelicano H., Chiao P.J., Achanta G., Arlinghaus R.B., Liu J., and Huang P. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell 10 (2006) 241-252
29. Wasylyk C., Zheng H., Castell C., Debussche L., Multon M.C., and Wasylyk B. Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules. Cancer Res. 68 (2008) 1275-1283
30. Yamaguchi H., Noshita T., Kidachi Y., Umetsu H., Hayashi M., Komiyama K., Funayama S., and Ryoyama K. Isolation of ursolic acid from apple peels and its specific efficacy as a potent antitumor agent. J. Health Sci. 54 (2008) 654-660