Anti-nitric oxide production activity of isothiocyanates correlates with their polar surface area rather than their lipophilicity

European Journal of Medicinal Chemistry

Volumn 44, Issue 12, 2009, Pages 4931-4936

  Noshita, Toshiro ^a   Kidachi, Yumi ^b   Funayama, Hirokazu ^b   Kiyota, Hiromasa ^c   Yamaguchi, Hideaki ^d   Ryoyama, Kazuo ^b  

^a PREFECTURAL UNIVERSITY OF HIROSHIMA   (Japan)

^b AOMORI UNIVERSITY   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

^d MEIJO UNIVERSITY   (Japan)

Author keywords

Isothiocyanates; Nitric oxide; Polar surface area; Structure activity relationship; Wasabi

Indexed keywords

(6 CHLOROHEXYL) (METHYL) SULFANE; 1 (METHYLSULFINYL) 6 THIOCYANATOHEXANE; 1 (METHYLTHIO) 6 THIOCYANATOHEXANE; 1 ISOTHIOCYANATO 6 (METHYLTHIO)HEXANE; 1 ISOTHIOCYANATO 6 METHOXYHEXANE; 2 (6 ISOTHIOCYANATOHEXYLOXY) TETRAHYDRO 2H PYRAN; 6 ISOTHIOCYANATOHEXAN 1 OL; 6 ISOTHIOCYANATOHEXANAL; 6 ISOTHIOCYANATOHEXYL 2,2,2 TRIFLUOROACETATE; 6 ISOTHIOCYANATOHEXYL ACETATE; ISOTHIOCYANIC ACID DERIVATIVE; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL CULTURE; DRUG MECHANISM; ENZYME ACTIVITY; EXPERIMENTAL MODEL; IN VITRO STUDY; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SURFACE PROPERTY; TUMOR CELL; TUMOR GROWTH; WASABI;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; DRUG SCREENING ASSAYS, ANTITUMOR; ISOTHIOCYANATES; MICE; NITRIC OXIDE; PLANT PREPARATIONS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; WASABIA;

EID: 70449686262     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.08.005     Document Type: Article

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