Acidic triterpenes compromise growth and survival of astrocytoma cell lines by regulating reactive oxygen species accumulation

Cancer Research

Volumn 67, Issue 8, 2007, Pages 3741-3751

  Martín, Rubén ^a   Carvalho, Juliana ^a   Ibeas, Elvira ^a   Hernández, Marita ^a   Ruiz Gutierrez, Valentina ^b   Nieto, María Luisa ^a  

^a UNIVERSITY OF VALLADOLID   (Spain)

^b INSTITUTO DE LA GRASA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; ACTIN; ANTIOXIDANT; BUTYLCRESOL; CASPASE 3; CATALASE; LIPOCORTIN 5; MASLINIC ACID; OLEANOLIC ACID; REACTIVE OXYGEN METABOLITE; TRITERPENE DERIVATIVE;

APOPTOSIS; ARTICLE; ASTROCYTOMA; CANCER CELL CULTURE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; CYTOSKELETON; DRUG INHIBITION; DRUG ISOLATION; DRUG MECHANISM; ENZYME ACTIVATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL MEMBRANE; OLIVE; PRIORITY JOURNAL; REGULATORY MECHANISM; STELLATE CELL; STRESS FIBER;

APOPTOSIS; ASTROCYTOMA; BRAIN NEOPLASMS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL SURVIVAL; CYTOSKELETON; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; OLEANOLIC ACID; REACTIVE OXYGEN SPECIES; TRITERPENES;

EID: 34248597759     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-4759     Document Type: Article

References (48)

1. Staunton MJ, Gaffney EF. Tumour type is a determinant of susceptibility to apoptosis. Am J Clin Pathol 1995;103:300-7.
2. Tannock IF. Cell proliferation. In: Tannock IF, Hill RP, editors. The basic science of oncology. 2nd ed. New York: McGraw-Hill, Inc.; 1990. p. 154-77.
3. Corcoran GB, Fix L, Jones DP, et al. Apoptosis: molecular control point in toxicity. Toxicol Appl Pharmacol 1994;128:169-81.
4. Green DR. Apoptotic pathways: paper wraps stone blunts scissors. Cell 2000;102:1-4.
5. Wang X. The expanding role of mitochondria in apoptosis. Genes Dev 2001;15:2922-33.
6. Hengartner MO. The biochemistry of apoptosis. Nature 2000;407:770-6.
7. Chinnaiyan AM, Dixit VM. The cell-death machine. Curr Biol 1996;6:555-62.
8. Zhivotovsky B, Burgess DH, Orrenius S. Proteases in apoptosis. Experientia 1996;52:968-78.
9. Arends MJ, Wyllie AH. Apoptosis: mechanisms and roles in pathology. Int Rev Exp Pathol 1991;32:223-54.
10. Cohen JJ, Duke RC, Fadok VA, Sellins KS. Apoptosis and programmed cell death in immunity. Annu Rev Immunol 1992;10:267-93.
11. Buttke TM, Sandstrom PA. Oxidative stress as a mediator of apoptosis. Immunol Today 1994;15:7-10.
12. Green DR, Kroemer G. The pathophysiology of mitochondrial cell death. Science 2004;305:626-9.
13. Saelens X, Festjens N, Walle LV, et al. Toxic proteins released from mitochondria in cell death. Oncogene 2004;23:2861-74.
14. Muzio M, Chinnaiyan AM, Kischkel FC, et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 1996;85:817-27.
15. Boldin MP, Goncharov TM, Goltsev YV, Wallach D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 1996;85:803-15.
16. Ashkenazi A. Targeting death and decoy receptors of the tumor-necrosis factor superfamily. Nat Rev Cancer 2002;2:420-30.
17. Johnstone RW, Ruefli AA, Lowe SW. Apoptosis: a link between cancer genetics and chemotherapy. Cell 2002;108:153-64.
18. Fulda S, Debatin KM. Targeting apoptosis pathways in cancer therapy. Curr Cancer Drug Targets 2004;4:569-76.
19. Huang MT, Ho CT, Wang Z, et al. Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. Cancer Res 1994;54:701-8.
20. Nishino H, Nishino A, Takayasu J, et al. Inhibition of the tumor-promoting action of 12-O-tetradecanoylphorbol-13-acetate by some oleanane-type triterpenoid compounds. Cancer Res 1988;48:5210-5.
21. Yoshimi N, Wang A, Morishita Y, et al. Modifying effects of fungal and herb metabolites on azoxymethane-induced intestinal carcinogenesis in rats. Jpn J Cancer Res 1992;83:1273-8.
22. Sohn KH, Lee HY, Chung HY, Young HS, Yi SY, Kim KW. Anti-angiogenic activity of triterpene acids. Cancer Lett 1995;94:213-8.
23. Tokuda H, Ohigashi H, Koshimizu K, Ito Y. Inhibitory effects of ursolic and oleanolic acid on skin tumor promotion by 12-O-tetradecanoylphorbol- 13-acetate. Cancer Lett 1986;33:279-85.
24. Hsu HY, Yang JJ, Lin CC. Effects of oleanolic acid and ursolic acid on inhibiting tumor growth and enhancing the recovery of hematopoietic system postirradiation in mice. Cancer Lett 1997;111:7-13.
25. Juan ME, Wenzel U, Ruiz-Gutierrez V, Daniel H, Planas JM. Olive fruit extracts inhibit proliferation and induce apoptosis in HT-29 human colon cancer cells. J Nutr 2006;136:2553-7.
26. Tsang WP, Chau SP, Kong SK, Fung KP, Kwok TT. Reactive oxygen species mediate doxorubicin induced-p53-independent apoptosis. Life Sci 2003;73:2047-58.
27. Jacobson MD. Reactive oxygen species and programmed cell death. Trends Biochem Sci 1996;21:83-6.
28. Liu J. Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol 1995;49:57-68.
29. Li J, Guo W-J, Yang Q-Y. Effects of ursolic acid and oleanolic acid on human colon carcinoma cell line HCT15. World J Gastroenterol 2002;8:493-5.
30. Hata K, Hori Ki, Takahashi S. Differentiation- and apoptosis-inducing activities by pentacyclic triterpenes on a mouse melanoma cell line. J Nat Prod 2002;65:645-8.
31. Ko H-H, Yen M-H, Wu R-R, Won S-J, Lin C-N. Cytotoxic isoprenylated flavans of Broussonetia kazinoki. J Nat Prod 1999;62:164-6.
32. Taniguchi S, Imayoshi Y, Kobayashi E, et al. Production of bioactive triterpenes by Eriobotrya japonica calli. Phytochemistry 2002;59:315-23.
33. Amico V, Barresi V, Condorelli D, Spatafora C, Tringal C. Antiproliferative terpenoids from almond hulls (Prunus dulcis): identification and structure-activity relationships. J Agric Food Chem 2006;54:810-4.
34. Choi CY, You HJ, Jeong HG. Nitric oxide and tumor necrosis factor-α production by oleanolic acid via nuclear factor-κB activation in macrophages. Biochem Biophys Res Commun 2001;288:49-55.
35. Reyes F, Centelles J, Lupiáñez J, Cascante M. (2α,3β)-2,3-Dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells. FEBS Lett 2006;580:6302-10.
36. Sethi G, Ahn KS, Pandey MK, Aggarwal BB. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-{κ}B-regulated gene products and TAK1-mediated NF-{κ}B activation. Blood 2006. Epub ahead of print.
37. Stadheim TA, Suh N, Ganju N, Sporn MB, Eastman A. The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells. J Biol Chem 2002;277:16448-55.
38. Hans SS, Peng L, Chung ST, et al. CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms. Mol Cancer 2006;5:22-37.
39. Stark LA, Reid K, Sansom OJ, et al. Aspirin activates the NF-{κ}B signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. Carcinogenesis 2006. Epub ahead of print.
40. Ramdas J, Harmon JM. Glucocorticoid-induced apoptosis and regulation of NF-κB activity in human leukemic T cells. Endocrinology 1998;139:3813-21.
41. Tong X, Lin S, Fujii M, Hou DX. Echinocystic acid induces apoptosis in HL-60 cells through mitochondria-mediated death pathway. Cancer Lett 2004;212:21-32.
42. Yue P, Zhou Z, Khuri FR, Sun SY. Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate (CDDO-Me). Cancer Biol Ther 2006;5:492-7.
43. Ayscough KR, Gourlay CW. The actin cytoskeleton: a key regulator of apoptosis and ageing? Nat Rev Mol Cell Biol 2005;6:583-9.
44. Mashima T, Naito M, Fujita N, Noguchi K, Tsuruo T. Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in Vp-16-induced U937 apoptosis. Biochem Biophys Res Commun 1995;217:1185-92.
45. Byun Y, Chen F, Chang R, Trivedi M, Green KJ, Cryns VL. Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis. Cell Death Differ 2001;8:443-50.
46. Duncan KL, Duncan MD, Alley MC, Sausville EA. Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells. Biochem Pharmacol 1996;52:1553-60.
47. Engeland MV, Kuijpers HJ, Ramaekers FC, Reutelingsperger CP, Schutte B. Plasma membrane alterations and cytoskeletal changes in apoptosis. Exp Cell Res 1997;235:421-30.
48. Grzanka A, Grzanka D, Orlikowska M. Cytoskeletal reorganization during process of apoptosis induced by cytostatic drugs in K-562 and HL-60 leukemia cell lines. Biochem Pharmacol 2003;66:1611-7.