Expression of the 11β-hydroxysteroid dehydrogenase type II enzyme in breast tumors and modulation of activity and cell growth in PMC42 cells

Journal of Steroid Biochemistry and Molecular Biology

Volumn 76, Issue 1-5, 2001, Pages 153-159

  Koyama, Kaori ^a   Myles, Kathy ^a   Smith, Robin ^a   Krozowski, Zygmunt ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

Breast cancer; Glucocorticoid; RU 38486; Spironolactone

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 11BETA HYDROXYSTEROID DEHYDROGENASE TYPE II; ALDOSTERONE; GLYCYRRHETINIC ACID; HYDROCORTISONE; MIFEPRISTONE; MINERALOCORTICOID RECEPTOR; OXPRENOATE POTASSIUM; PROGESTERONE RECEPTOR; SPIRONOLACTONE; STEROID RECEPTOR; UNCLASSIFIED DRUG; GLUCOCORTICOID RECEPTOR; HSD11B2 PROTEIN, HUMAN; HYDROXYSTEROID DEHYDROGENASE;

BREAST CANCER; CANCER CELL; CELL COUNT; CELL GROWTH; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; HORMONE METABOLISM; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; RECEPTOR BINDING; WESTERN BLOTTING; ARTICLE; BREAST TUMOR; CELL DIVISION; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; METABOLISM; PATHOLOGY;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ALDOSTERONE; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL DIVISION; CELL LINE; HUMANS; HYDROXYSTEROID DEHYDROGENASES; MIFEPRISTONE; RECEPTORS, GLUCOCORTICOID; RECEPTORS, MINERALOCORTICOID; SPIRONOLACTONE;

EID: 0034743757     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(00)00157-6     Document Type: Conference Paper

References (31)

1. Rat liver 11beta-hydroxysteroid dehydrogenase complementary deoxyribonucleic acid encodes oxoreductase activity in a mineralocorticoid-responsive toad bladder cell line
2. Mineralocorticoid action: Target tissue specificity is enzyme, not receptor, mediated
3. Localisation of 11 beta-hydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptor
4. Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme
5. Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase
6. 11 beta-Hydroxysteroid dehydrogenase
7. Epithelial and adipose cells isolated from mammary glands of pregnant and lactating rats differ in 11 beta-hydroxysteroid dehydrogenase activity
8. Localization of mineralocorticoid receptor and 11 beta-hydroxysteroid dehydrogenase type II in human breast and its disorders
9. The effects of glucocorticoids and progesterone on hormone-responsive human breast cancer in long-term tissue culture
10. Glucocorticoids induce a G1/G0 cell cycle arrest of Con8 rat mammary tumor cells that is synchronously reversed by steroid withdrawal or addition of transforming growth factor-alpha
11. Prednisolone improves the response to primary endocrine treatment for advanced breast cancer
12. A new human breast carcinoma cell line (PMC42) with stem cell characteristics. II: Characterization of cells growing as organoids
13. Truncation of the N- and C-terminal regions of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme and effects on solubility and bidirectional enzyme activity
14. Localization of 11 beta-hydroxysteroid dehydrogenase type II in human epithelial tissues
15. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding
16. Inhibition of 11 beta-hydroxysteroid dehydrogenase activity enhances the antiproliferative effect of glucocorticosteroids on MCF-7 and ZR-75-1 breast cancer cells
17. The R337C mutation generates a high km 11 beta-hydroxysteroid dehydrogenase type II enzyme in a family with apparent mineralocorticoid excess
18. Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase
19. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
20. Cell-specific, promoter-dependent mineralocorticoid agonist activity of spironolactone
21. Efficacy and tolerance of spironolactone in essential hypertension
22. 11 beta-hydroxysteroid dehydrogenase activity in the mammary gland
23. A new human breast carcinoma cell line (PMC42) with stem cell characteristics. III. Hormone receptor status and responsiveness
24. Licorice inhibits corticosteroid 11 beta-dehydrogenase of rat kidney and liver: In vivo and in vitro studies
25. In vivo and in vitro effects of carbenoxolone on glucocorticoid receptor binding and glucocorticoid activity
26. Additive stimulatory action of glucocorticoids and androgens on basal and estrogen-repressed apolipoprotein-D messenger ribonucleic acid levels and secretion in human breast cancer cells
27. Partial colocalization of glucocorticoid and mineralocorticoid receptors in discrete compartments in nuclei of rat hippocampus neurons
28. RU486 (mifepristone): Mechanisms of action and clinical uses
29. Colocalization of 11 beta-hydroxysteroid dehydrogenase type II and mineralocorticoid receptor in human epithelia
30. Expression of 11beta-hydroxysteroid dehydrogenase type 2 in an ACTH-producing small cell lung cancer
31. Kinetics and dynamics of orally administered 18 beta-glycyrrhetinic acid in humans