Forced gating motions by a substituted titratable side chainat the bundle crossing of a potassium channel

Journal of Biological Chemistry

Volumn 286, Issue 42, 2011, Pages 36686-36693

  Khurana, Anu ^a   Shao, Evan S ^a   Kim, Robin Y ^a   Vilin, Yury Y ^a   Huang, Xinyang ^a   Yang, Runying ^a   Kurata, Harley T ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PH; AROMATIC RESIDUES; ATP-BINDING SITE; CHANNEL ACTIVATION; CHANNEL GATING; CHANNEL OPENING; CLOSE PROXIMITY; CONFORMATIONAL CHANGE; EXTRINSIC CONTROL; FUNCTIONAL GATES; HELIX BUNDLE; MUTUAL REPULSION; PHYSIOLOGICAL PH; POTASSIUM CHANNELS; SELECTIVITY FILTER; SIDE-CHAINS; WILD TYPES;

ALKALINITY; DISTILLATION; PH EFFECTS; PHYSIOLOGY; SCAFFOLDS;

POTASSIUM;

ADENOSINE TRIPHOSPHATE; GLUTAMIC ACID; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; MUTANT PROTEIN;

ALKALINIZATION; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; BUNDLE CROSSING REGION; CELL PH; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DEPROTONATION; FORCED CHANNEL GATING MOTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; PROTON TRANSPORT; STOICHIOMETRY;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; MICE; MUTATION, MISSENSE; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN CONFORMATION; XENOPUS LAEVIS;

EID: 80054692647     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.249110     Document Type: Article

References (44)

1. Kubo, Y., Adelman, J. P., Clapham, D. E., Jan, L. Y., Karschin, A., Kurachi, Y., Lazdunski, M., Nichols, C. G., Seino, S., and Vandenberg, C. A. (2005) Pharmacol. Rev. 57, 509-526
2. Kubo, Y., Reuveny, E., Slesinger, P. A., Jan, Y. N., and Jan, L. Y. (1993) Nature 364, 802-806
3. Kubo, Y., Baldwin, T. J., Jan, Y. N., and Jan, L. Y. (1993) Nature 362, 127-133
4. Ho, K., Nichols, C. G., Lederer, W. J., Lytton, J., Vassilev, P. M., Kanazirska, M. V., and Hebert, S. C. (1993) Nature 362, 31-38
5. Inagaki, N., Gonoi, T., Clement, J. P., 4th, Namba, N., Inazawa, J., Gonzalez, G., Aguilar-Bryan, L., Seino, S., and Bryan, J. (1995) Science 270, 1166-1170
6. Lopatin, A. N., Makhina, E. N., and Nichols, C. G. (1994) Nature 372, 366-369
7. Shyng, S. L., and Nichols, C. G. (1998) Science 282, 1138-1141
8. Baukrowitz, T., Schulte, U., Oliver, D., Herlitze, S., Krauter, T., Tucker, S. J., Ruppersberg, J. P., and Fakler, B. (1998) Science 282, 1141-1144
9. Rohács, T., Chen, J., Prestwich, G. D., and Logothetis, D. E. (1999) J. Biol. Chem. 274, 36065-36072
10. Aguilar-Bryan, L., Nichols, C. G., Wechsler, S. W., Clement, J. P., 4th, Boyd, A. E., 3rd, González, G., Herrera-Sosa, H., Nguy, K., Bryan, J., and Nelson, D. A. (1995) Science 268, 423-426
11. Inagaki, N., Gonoi, T., Clement, J. P., Wang, C. Z., Aguilar-Bryan, L., Bryan, J., and Seino, S. (1996) Neuron 16, 1011-1017
12. Shyng, S., and Nichols, C. G. (1997) J. Gen. Physiol. 110, 655-664
13. Clement, J. P., 4th, Kunjilwar, K., Gonzalez, G., Schwanstecher, M., Panten, U., Aguilar-Bryan, L., and Bryan, J. (1997) Neuron 18, 827-838
14. Kuo, A., Gulbis, J. M., Antcliff, J. F., Rahman, T., Lowe, E. D., Zimmer, J., Cuthbertson, J., Ashcroft, F. M., Ezaki, T., and Doyle, D. A. (2003) Science 300, 1922-1926
15. Proks, P., Antcliff, J. F., and Ashcroft, F. M. (2003) EMBO Rep. 4, 70-75
16. Claydon, T. W., Makary, S. Y., Dibb, K. M., and Boyett, M. R. (2003) J. Biol. Chem. 278, 50654-50663
17. Xiao, J., Zhen, X. G., and Yang, J. (2003) Nat. Neurosci. 6, 811-818
18. Clarke, O. B., Caputo, A. T., Hill, A. P., Vandenberg, J. I., Smith, B. J., and Gulbis, J. M. (2010) Cell 141, 1018-1029
19. Kurata, H. T., Phillips, L. R., Rose, T., Loussouarn, G., Herlitze, S., Fritzenschaft, H., Enkvetchakul, D., Nichols, C. G., and Baukrowitz, T. (2004) J. Gen. Physiol. 124, 541-554
20. Kurata, H. T., Rapedius, M., Kleinman, M. J., Baukrowitz, T., and Nichols, C. G. (2010) PLoS Biol. 8, e1000315
21. Xu, H., Wu, J., Cui, N., Abdulkadir, L., Wang, R., Mao, J., Giwa, L. R., Chanchevalap, S., and Jiang, C. (2001) J. Biol. Chem. 276, 38690-38696
22. Lindman, S., Linse, S., Mulder, F. A., and André, I. (2007) Biophys. J. 92, 257-266
23. Berneche, S., and Roux, B. (2002) Biophys. J. 82, 772-780
24. Craig, T. J., Ashcroft, F. M., and Proks, P. (2008) J. Gen. Physiol. 132, 131-144
25. Shyng, S., Ferrigni, T., and Nichols, C. G. (1997) J. Gen. Physiol. 110, 141-153
26. Tucker, S. J., Gribble, F. M., Zhao, C., Trapp, S., and Ashcroft, F. M. (1997) Nature 387, 179-183
27. Lorenz, E., Alekseev, A. E., Krapivinsky, G. B., Carrasco, A. J., Clapham, D. E., and Terzic, A. (1998) Mol. Cell. Biol. 18, 1652-1659
28. Wang, R., Su, J., Zhang, X., Shi, Y., Cui, N., Onyebuchi, V. A., and Jiang, C. (2006) J. Membr. Biol. 213, 155-164
29. Zerangue, N., Schwappach, B., Jan, Y. N., and Jan, L. Y. (1999) Neuron 22, 537-548
30. Yan, F. F., Casey, J., and Shyng, S. L. (2006) J. Biol. Chem. 281, 33403-33413
31. Koster, J. C., Remedi, M. S., Dao, C., and Nichols, C. G. (2005) Diabetes 54, 2645-2654
32. Proks, P., Girard, C., Haider, S., Gloyn, A. L., Hattersley, A. T., Sansom, M. S., and Ashcroft, F. M. (2005) EMBO Rep. 6, 470-475
33. Shyng, S. L., Cukras, C. A., Harwood, J., and Nichols, C. G. (2000) J. Gen. Physiol. 116, 599-608
34. Enkvetchakul, D., Loussouarn, G., Makhina, E., Shyng, S. L., and Nichols, C. G. (2000) Biophys. J. 78, 2334-2348
35. Nishida, M., Cadene, M., Chait, B. T., and MacKinnon, R. (2007) EMBO J. 26, 4005-4015
36. Kuo, A., Domene, C., Johnson, L. N., Doyle, D. A., and Vénien-Bryan, C. (2005) Structure 13, 1463-1472
37. Phillips, L. R., and Nichols, C. G. (2003) J. Gen. Physiol. 122, 795-804
38. Phillips, L. R., Enkvetchakul, D., and Nichols, C. G. (2003) Neuron 37, 953-962
39. Rojas, A., Wu, J., Wang, R., and Jiang, C. (2007) Biochim. Biophys. Acta 1768, 39-51
40. Kurata, H. T., Marton, L. J., and Nichols, C. G. (2006) J. Gen. Physiol. 127, 467-480
41. Loussouarn, G., Makhina, E. N., Rose, T., and Nichols, C. G. (2000) J. Biol. Chem. 275, 1137-1144
42. Tao, X., Avalos, J. L., Chen, J., and MacKinnon, R. (2009) Science 326, 1668-1674
43. Long, S. B., Campbell, E. B., and MacKinnon, R. (2005) Science 309, 897-903
44. Doyle, D. A., Morais Cabral, J., Pfuetzner, R. A., Kuo, A., Gulbis, J. M., Cohen, S. L., Chait, B. T., and MacKinnon, R. (1998) Science 280, 69-77