Gating of the ATP-sensitive K+ channel by a pore-lining phenylalanine residue

Biochimica et Biophysica Acta - Biomembranes

Volumn 1768, Issue 1, 2007, Pages 39-51

  Rojas, Asheebo ^a   Wu, Jianping ^a   Wang, Runping ^a   Jiang, Chun ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

Author keywords

Gating; Hydrophobicity; KATP channel; Kir6.2; Steric hindrance

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; AMINO ACID; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; PHENYLALANINE; PROTON; TRYPTOPHAN;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; FEMALE; HYDROPHOBICITY; ION CONDUCTANCE; KINETICS; MUTANT; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; STEREOSPECIFICITY; WILD TYPE;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; FEMALE; HYDROGEN-ION CONCENTRATION; HYDROPHOBICITY; ION CHANNEL GATING; KINETICS; MEMBRANE POTENTIALS; MICROINJECTIONS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; PHENYLALANINE; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN CONFORMATION; TRYPTOPHAN; XENOPUS LAEVIS;

EID: 33845396667     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2006.06.027     Document Type: Article

References (42)

1. + channels in cardiac muscle. Nature 305 (1983) 147-148
2. + channels in pancreatic B-cells. Nature 311 (1984) 271-273
3. Ashcroft F.M. Adenosine 5′-triphosphate-sensitive potassium channels. Annu. Rev. Neurosci. 11 (1988) 97-118
4. + channels and insulin secretion: their role in health and disease. Diabetologia 42 (1999) 903-919
5. Nichols C.G., and Lopatin A.N. Inward rectifier potassium channels. Annu. Rev. Physiol. 59 (1997) 171-191
6. + channels in the absence of the sulphonylurea receptor. Nature 387 (1997) 179-183
7. ATP channels. Science 282 (1998) 1141-1144
8. Shyng S.L., and Nichols C.G. Membrane phospholipid control of nucleotide sensitivity of KATP channels. Science 282 (1998) 1138-1141
9. + channels in skeletal muscle by intracellular protons. Nature 343 (1990) 375-377
10. ATP channels by intracellular acidosis. J. Biol. Chem. 276 (2001) 12898-12902
11. ATP channels. Annu. Rev. Physiol. 60 (1998) 667-687
12. + channels. Nat. Rev., Neurosci. 4 (2003) 957-967
13. Doyle D.A. Structural changes during ion channel gating. Trends Neurosci. 27 (2004) 298-302
14. Yellen G. The voltage-gated potassium channels and their relatives. Nature 419 (2002) 35-42
15. Jiang Y., Lee A., Chen J., Cadene M., Chait B.T., and MacKinnon R. Crystal structure and mechanism of a calcium-gated potassium channel. Nature 417 (2002) 515-522
16. + channel by pivoted bending of a transmembrane segment. Mol. Cell 10 (2002) 469-481
17. Kuo A., Gulbis J.M., Antcliff J.F., Rahman T., Lowe E.D., Zimmer J., Cuthbertson J., Ashcroft F.M., Ezaki T., and Doyle D.A. Crystal structure of the potassium channel KirBac1.1 in the closed state. Science 300 (2003) 1922-1926
18. Sackin H., Nanazashvili M., Palmer L.G., Krambis M., and Walters D.E. Structural locus of the pH gate in the Kir1.1 inward rectifier channel. Biophys. J. 88 (2005) 2597-2606
19. Sukharev S., Betanzos M., Chiang C.S., and Guy H.R. The gating mechanism of the large mechanosensitive channel MscL. Nature 409 (2001) 720-724
20. Unwin N. Acetylcholine receptor channel imaged in the open state. Nature 373 (1995) 37-43
21. Unwin N. Structure and action of the nicotinic acetylcholine receptor explored by electron microscopy. FEBS Lett. 555 (2003) 91-95
22. Wu J., Xu H., Yang Z., Wang Y., Mao J., and Jiang C. Protons activate homomeric Kir6.2 channels by selective suppression of the long and intermediate closures. J. Membr. Biol. 190 (2002) 105-116
23. 2 and pH. J. Gen. Physiol. 116 (2000) 33-45
24. + channels by decreases in intra- and extracellular pH. J. Cell. Physiol. 183 (2000) 53-64
25. + and ATP. J. Physiol. 543 (2002) 495-504
26. Colquhoun D., and Hawkes A.G. The principles of the stochastic interpretation of ion-channel mechanisms. In: Sakmann B., and Neher E. (Eds). Single-Channel Recording (1995), Plenum Press, New York 397-482
27. Trapp S., Proks P., Tucker S.J., and Ashcroft F.M. Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP. J. Gen. Physiol. 112 (1998) 333-349
28. + conduction and selectivity. Science 280 (1998) 69-77
29. Light P.E., Bladen C., Winkfein R.J., Walsh M.P., and French R.J. Molecular basis of protein kinase C-induced activation of ATP-sensitive potassium channels. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 9058-9063
30. Lin Y.F., Jan Y.N., and Jan L.Y. Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cells. EMBO J. 19 (2000) 942-955
31. + channel by 8-azido-ATP. J. Biol. Chem. 274 (1999) 3931-3933
32. + channel Kir6.2 revealed by fluorescence resonance energy transfer. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 76-81
33. +-induced anomalous rectification in squid giant axons. J. Gen. Physiol. 273 (1966) F516-F529
34. Flynn G.E., and Zagotta W.N. Conformational changes in S6 coupled to the opening of cyclic nucleotide-gated channels. Neuron 30 (2001) 689-698
35. Johnson Jr. J.P., and Zagotta W.N. Rotational movement during cyclic nucleotide-gated channel opening. Nature 412 (2001) 917-921
36. +-channel activation gating. Science 285 (1999) 73-78
37. + channels. Neuron 37 (2003) 953-962
38. Shin K.S., Rothberg B.S., and Yellen G. Blocker state dependence and trapping in hyperpolarization-activated cation channels: evidence for an intracellular activation gate. J. Gen. Physiol. 117 (2001) 91-101
39. Capener C.E., Shrivastava I.H., Ranatunga K.M., Forrest L.R., Smith G.R., and Sansom M.S. Homology modeling and molecular dynamics simulation studies of an inward rectifier potassium channel. Biophys. J. 78 (2000) 2929-2942
40. Kyte J., and Doolittle R.F. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157 (1982) 105-132
41. Wimley W.C., and White S.H. Experimentally determined hydrophobicity scale for proteins at membrane interfaces. Nat. Struct. Biol. 3 (1996) 842-848
42. White S.H., and Wimley W.C. Membrane protein folding and stability: physical principles. Annu. Rev. Biophys. Biomol. Struct. 28 (1999) 319-365