Synthesis of diastereomerically pure nucleotide phosphoramidates

Journal of Organic Chemistry

Volumn 76, Issue 20, 2011, Pages 8311-8319

  Ross, Bruce S ^a   Ganapati Reddy, P ^a   Zhang, Hai Ren ^a   Rachakonda, Suguna ^a   Sofia, Michael J ^a  

^a PHARMASSET INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID ESTERS; ANTI-VIRAL DRUGS; DIASTEREOMERIC PURITY; DIASTEREOMERS; ELECTRON-WITHDRAWING SUBSTITUENTS; HIGH YIELD; HYDROXYL GROUPS; IN-VITRO; NUCLEOPHILIC DISPLACEMENT; NUCLEOSIDE MONOPHOSPHATES; PHARMACEUTICAL RESEARCH; PHENOLIC GROUPS; PHOSPHORAMIDATES; PRODRUGS; SUBSTITUTED PHENOL;

AMINO ACIDS; NUCLEOTIDES; PHENOLS;

CHEMICAL REACTIONS;

ANTIVIRUS AGENT; ESTER DERIVATIVE; HYDROXYL GROUP; NUCLEOTIDE DERIVATIVE; NUCLEOTIDE PHOSPHORAMIDATE DERIVATIVE; PHENOL DERIVATIVE; PHOSPHORAMIDIC ACID DERIVATIVE; PSI 7977; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DIASTEREOISOMER; ELECTRON; HEPATITIS C VIRUS; NUCLEOPHILICITY; SYNTHESIS;

AMIDES; AMINO ACIDS; ANTIVIRAL AGENTS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA-DIRECTED RNA POLYMERASES; ELECTRONS; ESTERS; HEPACIVIRUS; HEPATITIS C; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOSIDES; NUCLEOTIDES; PHENOLS; PHOSPHORIC ACIDS; PRODRUGS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; URIDINE MONOPHOSPHATE; VIRAL PROTEINS;

EID: 80054115235     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo201492m     Document Type: Article

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