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0011836521
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note
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The existence of this cyclic intermediate is only postulated as its observation has not been reported in the literature, presumably due to the rapidity of its decomposition to the amino acyl phosphoramidate.
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5
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(b) Egron, D.; Lefebvre, I.; Périgaud, C.; Beltran, T.; Pompon, A.; Gosselin, G.; Aubertin, A.-M.; Imbach, J.-L. Bioorg. Med. Chem. Lett. 1998, 8, 1045.
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Imbach, J.-L.8
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10
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0030872397
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The use of L-alanine as amino acid has been reported to be optimum for unveiling the phosphate functionality, at least for certain cell lines: McGuigan, C.; Tsang, H.-W.; Cahard, D.; Turner, S.; Velaquez, S.; Salgado, A.; Bodois, L.; Naesens, L.; De Clercq, E.; Balzarini, J. Antiviral Res. 1997, 35, 195.
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(a) Siddiqui, A. Q.; Ballatore, C.; McGuigan, C.; De Clercq, E.; Balzarini, J. J. Med. Chem. 1999, 42, 393.
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(b) Manfredini, S.; Baraldi, P. G.; Durini, E.; Vertuani, S.; Balzarini, J.; De Clercq, E.; Karlsson, A.; Buzzoni, V.; Thelander, L. J. Med. Chem. 1999, 42, 3243.
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14
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0035717267
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A report describing a series of phosphoramidate derivatives has recently appeared: Harris, S. A.; McGuigan, C.; Andrei, G.; De Clercq, E.; Balzarini, J. Antiviral Chem. Chemother. 2002, 12, 293.
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Harris, S.A.1
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15
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0035863169
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(a) Lackey, D. B.; Groziak, M. P.; Sergeeva, M.; Beryt, M.; Boyer, C.; Stroud, R. M.; Sayre, P.; Park, J. W.; Johnston, P.; Slamon, D.; Shepard, H. M.; Pegram, M. Biochem. Pharmacol. 2001, 61, 179.
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U.S. Patent 6,245,750
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(c) Shepard, H. M. U.S. Patent 6,245,750.
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Shepard, H.M.1
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18
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0011868369
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note
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The report (ref 9) describes the major impurity as being the 3′,5′-di-acylated phosphoramidate.
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19
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0018667566
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Jones, A. S.; Verhelst, G.; Walker, R. T. Tetrahedron Lett. 1979, 45, 4415.
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Jones, A.S.1
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20
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0011909092
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note
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2:MeOH.
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