Synthesis and in vitro evaluation of novel indole-based sigma receptors ligands

Chemical Biology and Drug Design

Volumn 78, Issue 5, 2011, Pages 869-875

  Yarim, Mine ^a   Koksal, Meric ^a   Schepmann, Dirk ^b   Wünsch, Bernard ^b  

^a YEDITEPE UNIVERSITY   (Turkey)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Cytotoxicity assay; Drug design; Indole; Piperazine; Radio ligand binding assay; Radioligands; Sigma ligands

Indexed keywords

1 [3 [4 (2 FLUOROPHENYL)PIPERAZIN 1 YL]PROPYL] 1H INDOLE; 1 [3 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL]PROPYL] 1H INDOLE; 1 [3 [4 (PHENYL)PIPERAZIN 1 YL]PROPYL] 1H INDOLE; 1 [[4 (2 PHENYLETHYL)PIPERAZIN 1 YL]METHYL] 3 METHYL 1H INDOLE; 1 [[4 (4 FLUOROPHENYL)PIPERAZIN 1 YL]METHYL] 3 METHYL 1H INDOLE; 1,3 DI [[4 (4 FLUOROPHENYL)PIPERAZIN 1 YL]METHYL] 1H INDOLE; 3 [[4 (2,5 DIFLUOROBENZYL)PIPERAZIN 1 YL]METHYL] 1H INDOLE; 3 [[4 (3,4 DICHLOROBENZYL)PIPERAZIN 1 YL]METHYL] 1H INDOLE; 3 [[4 (4 FLUOROPHENYL)PIPERAZIN 1 YL]METHYL] 1H INDOLE; CYTOTOXIC AGENT; INDOLE DERIVATIVE; RADIOLIGAND; SIGMA 1 OPIATE RECEPTOR; SIGMA 2 OPIATE RECEPTOR; SIGMA RECEPTOR LIGAND; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CANCER CELL CULTURE; CELL STRAIN MCF 7; CYTOTOXICITY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; INFRARED SPECTROSCOPY; LIVER HOMOGENATE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLES; LIGANDS; PIPERAZINES; RECEPTORS, SIGMA;

EID: 80054106199     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2011.01215.x     Document Type: Article

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