Synthesis of bridged piperazines with σ receptor affinity

European Journal of Medicinal Chemistry

Volumn 42, Issue 10, 2007, Pages 1247-1262

  Weigl, Manuela ^a   Wünsch, Bernhard ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Receptor ligands; 6,8 Diazabicyclo 3.2.2 nonane; Chiral pool synthesis; Dieckmann cyclization; Structure affinity relationships

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; 6 BENZYL 2 BENZYLOXY 8 BUTYL 6,8 DIAZABICYCLO[3.2.2]NONANE; 6 BENZYL 2 BENZYLOXY 8 METHYL 6,8 DIAZABICYCLO[3.2.2]NONANE; 6 BENZYL 2 METHOXY 8 METHYL 2 (TRIMETHYL SILOXY) 6,8 DIAZABICYCLO[3.2.2]NONANE 7,9 DIONE; 6 BENZYL 2 METHOXY 8 METHYL 6,8 DIAZABICYCLO[3.2.2]NONANE; 6 BENZYL 2,2 DIMETHOXY 8 METHYL 6,8 DIAZABICYCLO[3.2.2]NONANE 7,9 DIONE; 6 BENZYL 8 (2 PHENYLETHYL) 6,8 DIAZABICYCLO[3.2.2]NONAN 2 OL; 6 BENZYL 8 BUTYL 2 METHOXY 6,8 DIAZABICYCLO[3.2.2]NONANE; 6 BENZYL 8 BUTYL 2 METHOXY 8 (2 PHENYLETHYL) 6,8 DIAZABICYCLO[3.2.2]NONANE; 6 BENZYL 8 METHYL 6,8 DIAZABICYCLO[3.2.2]NONAN 2 OL; 6 BENZYL 8 METHYL 6,8 DIAZABICYCLO[3.2.2]NONANE 2 ONE DIMETHYL ACETAL; 6 BENZYL 8 METHYL 6,8 DIAZABICYCLO[3.2.2]NONANE 2,7,9 TRIONE; DITOLYLGUANIDINE; GUANIDINE DERIVATIVE; HALOPERIDOL; KETAMINE; KETONE; LITHIUM DERIVATIVE; PENTAZOCINE; PHENCYCLIDINE; PIPERAZINE DERIVATIVE; SIGMA RECEPTOR LIGAND; SODIUM BOROHYDRIDE; UNCLASSIFIED DRUG;

ACETALIZATION; ANIMAL TISSUE; ARTICLE; CATALYSIS; CHIRALITY; CONTROLLED STUDY; DIECKMANN REACTION; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; REDUCTION; WILLIAMSON REACTION;

CROSS-LINKING REAGENTS; MOLECULAR STRUCTURE; PIPERAZINES; RECEPTORS, SIGMA;

EID: 35148856716     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.02.005     Document Type: Article

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