The effects of antiepileptic drugs on the relationships between leptin levels and bone turnover in prepubertal children with epilepsy

Journal of Pediatric Endocrinology and Metabolism

Volumn 24, Issue 9-10, 2011, Pages 703-708

  Aksoy, Ayse ^a   Mujgan Sonmez F ^a   Deger, Orhan ^a   Hosver, Ilgin ^a   Karagüzel, Gülay ^a  

^a KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Epilepsy; Leptin; Prepubertal children

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM; CARBAMAZEPINE; CARBOXY TERMINAL TELOPEPTIDE; GLUCOSE; INSULIN; LEPTIN; OSTEOCALCIN; PHOSPHORUS; VALPROIC ACID; VITAMIN D;

ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; BONE MINERAL; BONE TURNOVER; CHILD; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DRUG BLOOD LEVEL; EPILEPSY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; OSSIFICATION; OSTEOLYSIS; PREPUBERTY; PRESCHOOL CHILD; SCHOOL CHILD; VITAMIN BLOOD LEVEL;

ANTICONVULSANTS; BIOLOGICAL MARKERS; BONE DENSITY; BONE REMODELING; CARBAMAZEPINE; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; EPILEPSY; FEMALE; HUMANS; LEPTIN; MALE; VALPROIC ACID;

EID: 80054085072     PISSN: 0334018X     EISSN: 21910251     Source Type: Journal    
DOI: 10.1515/JPEM.2011.019     Document Type: Article

References (48)

1. Szulc P, Seeman E, Delmas PD. Biochemical measurements of bone turnover in children and adolescents. Osteoporosis Int 2000;11:281-94. (Pubitemid 30417180)
2. Pack A. Bone health in people with epilepsy: is it impaired and what are the risk factors ? Seizure 2008;17:181-6.
3. Valsamis HA, Arora SK, Labban B, McFarlane SI. Antiepileptic drugs and bone metabolism. Nutr Metab (Lond) 2006;3:36.
4. Barden HS, Mazess RB, Chesney RW, Rose PG, Chun R. Bone status of children receiving anticonvulsant therapy. Metab Bone Dis Relat Res 1982;4:43-7.
5. Brodie MJ, Dichter MA. Antiepileptic drugs. N Engl J Med 1996;334:168-75.
6. Verrotti A, Coppola G, Parisi P, Mohn A, Chiarelli F. Bone and calcium metabolism and antiepileptic drugs. Clin Neurol Neurosur 2010;112:1-10.
7. Sheth RD, Wesolowski CA, Jacobs JC, Bodensteiner J, Riggs JE. Effect of carbamazepine and valproate on bone mineral density. J Pediatr 1995;127:256-62.
8. Soyka LA, Fairfield WP, Klinbanski A. Clinical review 117: hormonal determinants and disorders of peak bone mass in children. J Clin Endocr Metab 2000;85:3951-63. (Pubitemid 32055332)
9. Valimaki MJ, Tikhonen M, Laitinen K. Bone mineral density measured by dual-energy X-ray absorptiometry and novel markers of bone formation and resorption in patients on antiepileptic drugs. J Bone Miner Res 1994;9:631-7. (Pubitemid 24130463)
10. Tsukahara H, Kimura K, Todoroki Y, Ohshima Y, Hiraoka M, et al. Bone mineral status in ambulatory pediatric patients on longterm anti epileptic drug therapy. Pediatr Int 2002;44:247-53. (Pubitemid 34827720)
11. Akin R, Okutan V, Sarici U, Altunbas A, Gökcay E. Evaluation of bone mineral density in children receiving antiepileptic drugs. Pediatr Neurol 1998;19:129-31. (Pubitemid 28410390)
12. Kumandas S, Koklu E, Gümüs H, Koklu S, Kurtoglu S, et al. Effect of carbamazepine and valproic acid on bone mineral density, IGF-1 and IGFBF-3. J Pediatr Endocr Metab 2006;19:529-34. (Pubitemid 43772797)
13. Kafali G, Erselcan T, Tanzer F. Effect of antiepileptic drugs on bone mineral density in children between ages 6 and 12 years. Clin Pediatr (Phila) 1999;38:93-8. (Pubitemid 29086791)
14. Isojarvi JL, Laatikainen TJ, Knip M, Pakarinen AJ, Juntunen KT, et al. Obesity and endocrine diseases in women taking valproate for epilepsy. Ann Neurol 1996;39:579-84. (Pubitemid 26143595)
15. Hamed SA, Fida NM, Hamed EA. States of serum leptin and insulin in children with epilepsy: risk predictors of weight gain. Eur J Paediat Neurol 2009;13:261-8.
16. Espinosa PS, Salazar JC, Yu L, Mendiondo MS, Robertson WC, et al. Lack of valproic acid associated weight gain in prepubertal children. Pediatr Neurol 2008;39:177-80.
17. Isojarvi JI, Rattya J, Myllyla VV, Knip M, Koivunen R, et al. Valproate, lamotrigine, and insulin-mediated risks in women with epilepsy. Ann Neurol 1998;43:446-51. (Pubitemid 28231718)
18. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, et al. Serum immunoreactive-leptin concentrations in normal weight and obese humans. N Engl J Med 1996;334:292-5. (Pubitemid 26033933)
19. Huang L, Li C. Leptin: a multifunctional hormone. Cell Res 2000;10:81-92.
20. Thomas T, Burguera B. Is leptin link between fat and bone mass ? J Bone Miner Res 2002;17:1563-9.
21. The International League Against Epilepsy. Commission on Classification and Terminology. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989;30:389-99.
22. Scheuer ML, Pedley TA. The evaluation and treatment of seizures: current concepts. N Engl J Med 1990;323:1468-74. (Pubitemid 20384956)
23. Tanner JM, Whitehouse RH. Clinical longitudinal studies for height, weight, height velocity, weight velocity, and the stages of puberty. Arch Dis Child 1976;51:170-9.
24. Murphy SP, Poos MI. Dietary reference intakes: summary of applications in dietary assessment. Public Health Nutr 2002;5:843-9. (Pubitemid 36313627)
25. Neyzi O, Furman A, Bundak R, Gunoz H, Darendeliler F, Bas F. Growth references for Turkish children aged 6 to 18 years. Acta Paediatr. 2006;95:1635-41. (Pubitemid 44863818)
26. Babayigit A, Dirik E, Bober E, Cakmakc i H. Adverse effects of antiepileptic drugs on bone mineral density. Pediatr Neurol 2006;35:177-81. (Pubitemid 44291525)
27. Erbayat Altay E, Serdaroglu A, Tumer I, Gucuyener K, Hasanoglu AJ. Evaluation of bone mineral metabolism in children receiving carbamazepine and valproic acid. J Pediatr Endocr Metab 2000;13:933-9.
28. Verrotti A, Greco R, Morgese G, Chiarelli F. Increased bone turnover in epileptic patients treated with carbamazepine. Ann Neurol 2000;47:385-8. (Pubitemid 30141852)
29. Verrotti A, Greco R, Latini G, Morgese G, Chiarelli F. Increased bone turnover in prepubertal, pubertal, and postpubertal patients receiving carbamazepine. Epilepsia 2002;43:1488-92. (Pubitemid 35429765)
30. Voudris K, Moustaki M, Zeis PM, Dimou S, Vagiakou E, et al. Alkaline phosphatase and its isoenzyme activity for the evaluation of bone metabolism in children receiving anticonvulsant monotherapy. Seizure 2002;11:377-80. (Pubitemid 35154150)
31. Guo C, Ronen GM, Atkinson SA. Long-term valproate and lamotrigine treatment may be a marker for reduced growth and bone mass in children with epilepsy. Epilepsia 2001;42:1141-7. (Pubitemid 32947933)
32. Elwakkad AS, El Elshamy KA, Sibaii H. Fish liver oil and propolis as protective natural products against the effect of the antiepileptic drug valproate on immunological markers of bone formation in rats. Epilepsy Res 2008;80:47-56.
33. Sato M, Takeda N, Sarui H, Takami R, Takami K, et al. Association between serum leptin concentrations and bone mineral density, and biochemical markers of bone turnover in adult men. J Clin Endocr Metab 2001;86:5273-6. (Pubitemid 33070248)
34. Bonjour JP, Theintz G, Buchs B, Slosman D, Rizzoli R. Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence. J Clin Endocr Metab 1991;73:555-63. (Pubitemid 21921908)
35. Easter D, O'Bryan-Tear CG, Verity C. Weight gain with valproate or carbamazepine - a reappraisal. Seizure 1997;6:121-5. (Pubitemid 27220018)
36. Verrotti A, Basciani F, Morresi S, Morgese G, Chiarelli F. Serum leptin changes in epileptic patients who gain weight after therapy with valproic acid. Neurology 1999;53:230-2. (Pubitemid 29329682)
37. Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, et al. Developmental pharmacology - drug disposition, action, and therapy in infants and children. N Engl J Med 2003;349:1157-67. (Pubitemid 37122329)
38. Thomas T, Gori F, Khosla S, Jensen MD, Burguera B, et al. Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology 1999;140:1630-8. (Pubitemid 29149231)
39. Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 2000;100:197-207. (Pubitemid 30064908)
40. Horlick MB, Rosenbaum M, Nicolson M, Levine LS, Fedun B, et al. Effect of puberty on the relationship between circulating leptin and body composition. J Clin Endocr Metab 2000;85:2509-18. (Pubitemid 32269209)
41. Roemmich JN, Clark RA, Mantzoros CS, Gurgol CM, Weltman A, et al. Relationship of leptin to bone mineralization in children and adolescents. J Clin Endocr Metab 2003;88:599-604. (Pubitemid 36207797)
42. Iwamoto I, Douchi T, Koksa S. Relationship between serum leptin level and regional bone mineral density, bone metabolic markers in healthy women. Acta Obstet Gyn Scan 2000;79:1060-4.
43. Dencker M, Thorsson O, Karlsson MK, Lindén C, Svensson J, et al. Leptin is closely related to body fat in prepubertal children aged 8-11 years. Acta Paediatr 2006;95:975-9. (Pubitemid 44181219)
44. Matkovic V, Ilich JZ, Skugor M, Badenhop NE, Goel P, et al. Leptin is inversely related to age at menarche in human females. J Clin Endocr Metab 1997;82:3239-45. (Pubitemid 27419064)
45. Garnett SP, Hogler W, Blades B, Baur LA, Peat J, et al. Relation between hormones and body composition, including bone in prepubertal children. Am J Clin Nutr 2004;80:966-72. (Pubitemid 41202099)
46. Caksen H, Deda G, Berberoglu M. Does long-term use of valproate cause weight gain in prepubertal epileptic children ? Int J Neurosci 2002;112:1183-9. (Pubitemid 35293952)
47. Caksen H, Deda G, Berberoglu M, Içagasioglu D, Turan EB. Serum leptin levels in children receiving long-term carbamazepine. Acta Paediatr Taiwan 2003;44:82-3. (Pubitemid 36687540)
48. Aydin K, Serdaroglu A, Okuyaz C, Bideci A, Gucuyener K, et al. Serum insulin, leptin and neuropeptide-Y levels in epileptic children treated with valproate. J Child Neurol 2005;20:848-851. (Pubitemid 43124479)