Analytical metabolomics: Nutritional opportunities for personalized health

Journal of Nutritional Biochemistry

Volumn 22, Issue 11, 2011, Pages 995-1002

  McNiven, Elizabeth M S ^a   German, J Bruce ^a   Slupsky, Carolyn M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Clinical chemistry; Metabolomics; Nutrition; Personalized medicine; Toxicology

Indexed keywords

METHOTREXATE; SIMVASTATIN;

ACCURACY; DIET; GENOME; HUMAN; INTESTINE FLORA; LYMPHOMA; METABOLOMICS; NONHUMAN; PERSONALIZED MEDICINE; PREVENTIVE MEDICINE; REVIEW; TOXICITY TESTING;

ANIMALS; CARDIOVASCULAR DISEASES; DIET; HEALTH; HUMANS; INDIVIDUALIZED MEDICINE; METABOLOMICS; NEOPLASMS; NUTRITIONAL SCIENCES; TOXICOLOGY;

EID: 80054078496     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2011.05.016     Document Type: Review

References (89)

1. German J.B., Roberts M.A., Watkins S.M. Genomics and metabolomics as markers for the interaction of diet and health: lessons from lipids. J Nutr 2003, 133:2078S-2083S.
2. German J.B., Watkins S.M., Fay L.B. Metabolomics in practice: emerging knowledge to guide future dietetic advice toward individualized health. J Am Diet Assoc 2005, 105:1425-1432.
3. Slupsky C.M. Nuclear magnetic resonance-based analysis of urine for the rapid etiological diagnosis of pneumonia. Expert Opin Med Diagn 2011, 5:63-73.
4. Dettmer K., Aronov P.A., Hammock B.D. Mass spectrometry-based metabolomics. Mass Spectrom Rev 2007, 26:51-78.
5. Dragsted L.O. Biomarkers of meat intake and the application of nutrigenomics. Meat Sci 2010, 84:301-307.
6. O'Sullivan A., Gibney M.J., Brennan L. Dietary intake patterns are reflected in metabolomic profiles: potential role in dietary assessment studies. Am J Clin Nutr 2011, 93:314-321.
7. Altmaier E., Kastenmuller G., Romisch-Margl W., Thorand B., Weinberger K.M., Illig T., et al. Questionnaire-based self-reported nutrition habits associate with serum metabolism as revealed by quantitative targeted metabolomics. Eur J Epidemiol 2010.
8. Sha W., da Costa K.A., Fischer L.M., Milburn M.V., Lawton K.A., Berger A., et al. Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline. FASEB J 2010, 24:2962-2975.
9. Fernandes G. Progress in nutritional immunology. Immunol Res 2008, 40:244-261.
10. McCay C.M., Cromwell M.F., Maynard L.A. The effect of retarded growth upon the length of lifespan and ultimate body size. J Nutr 1935, 10:63-79.
11. Kristal B.S., Paolucci U. Caloric restriction in trans. Sci Aging Knowl Environ 2003, 9:PE19.
12. Fontana L., Weiss E.P., Villareal D.T., Klein S., Holloszy J.O. Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell 2008, 7:681-687.
13. Hall R.D., Brouwer I.D., Fitzgerald M.A. Plant metabolomics and its potential application for human nutrition. Physiol Plant 2008, 132:162-175.
14. Newgard C.B., An J., Bain J.R., Muehlbauer M.J., Stevens R.D., Lien L.F., et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab 2009, 9:311-326.
15. Kim J.Y., Park J.Y., Kim O.Y., Ham B.M., Kim H.J., Kwon D.Y., et al. Metabolic profiling of plasma in overweight/obese and lean men using ultra performance liquid chromatography and Q-TOF mass spectrometry (UPLC-Q-TOF MS). J Proteome Res 2010, 9:4368-4375.
16. Waldram A., Holmes E., Wang Y., Rantalainen M., Wilson I.D., Tuohy K.M., et al. Top-down systems biology modeling of host metabotype-microbiome associations in obese rodents. J Proteome Res 2009, 8:2361-2375.
17. Bertram H.C., Duus J.Ø., Petersen B.O., Hoppe C., Larnkjaer A., Schack-Nielsen L., et al. Nuclear magnetic resonance-based metabonomics reveals strong sex effect on plasma metabolism in 17-year-old Scandinavians and correlation to retrospective infant plasma parameters. Metab Clin Exp 2009, 58:1039-1045.
18. Assfalg M., Bertini I., Colangiuli D., Luchinat C., Schäfer H., Schütz B., et al. Evidence of different metabolic phenotypes in humans. Proc Natl Acad Sci 2008, 105:1420-1424.
19. Bernini P., Bertini I., Luchinat C., Nepi S., Saccenti E., Scha fer H., et al. Individual human phenotypes in metabolic space and time. J Proteome Res 2009, 8:4264-4271.
20. Holmes E., Loo R.L., Stamler J., Bictash M., Yap I.K.S., Chan Q., et al. Human metabolic phenotype diversity and its association with diet and blood pressure. Nature 2008, 453:396-400.
21. Graça G., Duarte I.F., Barros A.S., Goodfellow B.J., Diaz S., Carreira I.M., et al. (1)H NMR based metabonomics of human amniotic fluid for the metabolic characterization of fetus malformations. J Proteome Res 2009, 8:4144-4150.
22. Hayashi S., Akiyama S., Tamaru Y., Takeda Y., Fujiwara T., Inoue K., et al. A novel application of metabolomics in vertebrate development. Biochem Biophys Res Commun 2009, 386:268-272.
23. Seli E., Botros L., Sakkas D., Burns D.H. Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Fertil Steril 2008, 90:2183-2189.
24. Heazell A.E., Brown M., Worton S.A., Dunn W.B. Review: the effects of oxygen on normal and pre-eclamptic placental tissue - insights from metabolomics. Placenta 2010.
25. Romero R., Mazaki-Tovi S., Vaisbuch E., Kusanovic J.P., Chaiworapongsa T., Gomez R., et al. Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery. J Matern-Fetal Neonatal Med 2010, 23:1344-1359.
26. Gu H., Pan Z., Xi B., Hainline B., Shanaiah N., Asiago V., et al. 1H NMR metabolomics study of age profiling in children. NMR Biomed 2009, 826-833.
27. Slupsky C.M., Rankin K.N., Wagner J., Fu H., Chang D., Weljie A.M., et al. Investigations of the effects of gender, diurnal variaion, and age in human urinary metabolomic profiles. Anal Chem 2007, 79:6995-7004.
28. Yan B., A J., Wang G., Lu H., Huang X., Liu Y., et al. Metabolomic investigation into variation of endogenous metabolites in professional athletes subject to strength-endurance training. J Appl Physiol 2009, 106:531-538.
29. Law W.S., Huang P.Y., Ong E.S., Ong C.N., Li S., Pasikanti K.K., et al. Metabonomics investigation of human urine after ingestion of green tea with gas chromatography/mass spectrometry, liquid chromatography/mass spectrometry and 1H NMR spectroscopy. Rapid Commun Mass Spectrom 2008, 22:2436-2446.
30. Gieger C., Geistlinger L., Altmaier E., Hrabé de Angelis M., Kronenberg F., Meitinger T., et al. Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet 2008, 4:e1000282.
31. Martin F.P.J., Sprenger N., Yap I.K.S., Wang Y., Bibiloni R., Rochat F., et al. Panorganismal gut microbiome-host metabolic crosstalk. J Proteome Res 2009, 8:2090-2105.
32. Martin F.P.J., Rezzi S., Pere-Trepat E., Kamlage B., Collino S., Leibold E., et al. Metabolic effects of dark chocolate consumption on energy, gut microbiota, and stress-related metabolism in free-living subjects. J Proteome Res 2009, 5568-5579. in press.
33. He Q., Kong X., Wu G., Ren P., Tang H., Hao F., et al. Metabolomic analysis of the response of growing pigs to dietary l-arginine supplementation. Amino Acids 2009, 37:199-208.
34. Antunes L.M., Han J., Ferreira R.B., Lolic P., Borchers C.H., Finlay B.B. The effect of antibiotic treatment on the intestinal metabolome. Antimicrob Agents Chemother 2011.
35. Go V.L., Butrum R.R., Wong D.A. Diet, nutrition, and cancer prevention: the postgenomic era. J Nutr 2003, 133:3830S-3836S.
36. Lambert J.D., Sang S., Yang C.S. Possible controversy over dietary polyphenols: benefits vs risks. Chem Res Toxicol 2007, 20:583-585.
37. Walsh M.C., Brennan L., Pujos-Guillot E., Sébédio J.L., Scalbert A., Fagan A., et al. Influence of acute phytochemical intake on human urinary metabolomic profiles. Am J Clin Nutr 2007, 86:1687-1693.
38. Lee K.W., Lee H.J., Lee C.Y. Vitamins, phytochemicals, diets, and their implementation in cancer chemoprevention. Crit Rev Food Sci Nutr 2004, 44:437-452.
39. Ervin R.B., Wright J.D., Reed-Billette D. Prevalence of leading types of dietary supplements used in the third national health and nutrition examination survey, 1988-94. Vital Health Stat 2004, 349:1-8.
40. Manach C., Hubert J., Llorach R., Scalbert A. The complex links between dietary phytochemicals and human health deciphered by metabolomics. Mol Nutr Food Res 2009, 53:1303-1315.
41. Zhang A., Sun H., Wang Z., Sun W., Wang P., Wang X. Metabolomics: towards understanding traditional Chinese medicine. Planta Med 2010, 76:2026-2035.
42. Um S.Y., Chung M.W., Kim K.B., Kim S.H., Oh J.S., Oh H.Y., et al. Pattern recognition analysis for the prediction of adverse effects by nonsteroidal anti-inflammatory drugs using 1H NMR-based metabolomics in rats. Anal Chem 2009, 81:4734-4741.
43. Xie G., Zheng X., Qi X., Cao Y., Chi Y., Su M., et al. Metabonomic evaluation of melamine-induced acute renal toxicity in rats. J Proteome Res 2009, 9:125-133.
44. Wei L., Liao P., Wu H., Li X., Pei F., Li W., et al. Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum. Toxicol Appl Pharmacol 2007, 227:417-429.
45. Sun J., Schnackenberg L.K., Holland R., Schmitt T.C., Cantor G.H., Dragan Y.P., et al. Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS. J Chromatogr B Analyt Technol Biomed Life Sci 2008, 871:328-340.
46. Boudonck K.J., Mitchell M.W., Német L., Keresztes L., Nyska A., Shinar D., et al. Discovery of metabolomics biomarkers for early detection of nephrotoxicity. Toxicol Pathol 2009, 37:280-292.
47. Dieterle F., Schlotterbeck G., Ross A., Niederhauser U., Senn H. Application of metabonomics in a compound ranking study in early drug development revealing drug-induced excretion of choline into urine. Chem Res Toxicol 2006, 19:1175-1181.
48. Boudonck K.J., Rose D.J., Karoly E.D., Lee D.P., Lawton K.A., Lapinskas P.J. Metabolomics for early detection of drug-induced kidney injury: review of the current status. Bioanalysis 2009, 1:1645-1663.
49. Tyburski J.B., Patterson A.D., Krausz K.W., Slavík J., Fornace A.J., Gonzalez F.J., et al. Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice. Radiat Res 2009, 172:42-57.
50. Wang C., Yang J., Nie J. Plasma phospholipid metabolic profiling and biomarkers of rats following radiation exposure based on liquid chromatography-mass spectrometry technique. Biomed Chromatogr 2009, 23:1079-1085.
51. Sumner S., Snyder R., Burgess J., Myers C., Tyl R., Sloan C., et al. Metabolomics in the assessment of chemical-induced reproductive and developmental outcomes using non-invasive biological fluids: application to the study of butylbenzyl phthalate. J Appl Toxicol 2009, 29:703-714.
52. Swann J., Wang Y., Abecia L., Costabile A., Tuohy K., Gibson G., et al. Gut microbiome modulates the toxicity of hydrazine: a metabonomic study. Mol Biosyst 2009, 5:351-355.
53. Martin J.C., Canlet C., Delplanque B., Agnani G., Lairon D., Gottardi G., et al. (1)H NMR metabonomics can differentiate the early atherogenic effect of dairy products in hyperlipidemic hamsters. Atherosclerosis 2009, 206:127-133.
54. Carr T., Krogstrand K., Schlegel V., Fernandez M. Stearate-enriched plant sterol esters lower serum LDL cholesterol concentration in normo- and hypercholesterolemic adults. J Nutr 2009, 139:1445-1450.
55. Bertram H.C., Malmendal A., Nielsen N.C., Straadt I.K., Larsen T., Knudsen K.E., et al. NMR-based metabonomics reveals that plasma betaine increases upon intake of high-fiber rye buns in hypercholesterolemic pigs. Mol Nutr Food Res 2009, 53:1055-1062.
56. Sabatine M.S., Liu E., Morrow D.A., Heller E., McCarroll R., Wiegand R., et al. Metabolomic identification of novel biomarkers of myocardial ischemia. Circulation 2005, 112:3868-3875.
57. Vallejo M., García A., Tuñón J., García-Martínez D., Angulo S., Martin-Ventura J.L., et al. Plasma fingerprinting with GC-MS in acute coronary syndrome. Anal Bioanal Chem 2009, 394:1517-1524.
58. Lu Y., A J., Wang G., Hao H., Huang Q., Yan B., et al. Gas chromatography/time-of-flight mass spectrometry based metabonomic approach to differentiating hypertension- and age-related metabolic variation in spontaneously hypertensive rats. Rapid Commun Mass Spectrom 2008, 22:2882-2888.
59. Zhang F., Jia Z., Gao P., Kong H., Li X., Chen J., et al. Metabonomics study of atherosclerosis rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry. Talanta 2009, 79:836-844.
60. Zha W., A J., Wang G., Yan B., Gu S., Zhu X., et al. Metabonomic characterization of early atherosclerosis in hamsters with induced cholesterol. Biomarkers 2009, 14:372-380.
61. Ooga T., Sato H., Nagashima A., Sasaki K., Tomita M., Soga T., et al. Metabolomic anatomy of an animal model revealing homeostatic imbalances in dyslipidaemia. Mol Biosyst 2011.
62. Oresic M., Simell S., Sysi-Aho M., Näntö-Salonen K., Seppänen-Laakso T., Parikka V., et al. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med 2008, 205:2975-2984.
63. Shearer J., Duggan G., Weljie A.M., Hittel D.S., Wasserman D.H., Vogel H.J. Metabolomic profiling of dietary-induced insulin resistance in the high fat-fed C57BL/6J mouse. Diabetes Obes Metab 2008, 10:950-958.
64. Koves T.R., Ussher J.R., Noland R.C., Slentz D., Mosedale M., Ilkayeva O., et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 2008, 7:45-56.
65. Bao Y., Zhao T., Wang X., Qiu Y., Su M., Jia W., et al. Metabonomic variations in the drug-treated type 2 diatetes mellitus patients and healthy volunteers. J Proteome Res 2009, 8:1623-1630.
66. Rezzi S., Martin F.P., Alonso C., Guilarte M., Vicario M., Ramos L., et al. Metabotyping of biofluids reveals stress-based differences in gut permeability in healthy individuals. J Proteome Res 2009, 8:4799-4809.
67. Wang X., Zhao T., Qiu Y., Su M., Jiang T., Zhou M., et al. Metabonomics approach to understanding acute and chronic stress in rat models. J Proteome Res 2009, 8:2511-2518.
68. Li Z.Y., Zheng X.Y., Gao X.X., Zhou Y.Z., Sun H.F., Zhang L.Z., et al. Study of plasma metabolic profiling and biomarkers of chronic unpredictable mild stress rats based on gas chromatography/mass spectrometry. Rapid Commun Mass Spectrom 2010, 24:3539-3546.
69. Bertini I., Calabrò A., De Carli V., Luchinat C., Nepi S., Porfirio B., et al. The metabonomic signature of celiac disease. J Proteome Res 2009, 8:170-177.
70. Jansson J., Willing B., Lucio M., Fekete A., Dicksved J., Halfvarson J., et al. Metabolomics reveals metabolic biomarkers of Crohn's disease. PLoS ONE 2009, 4:e6386.
71. Otter D., Cao M., Lin H.M., Fraser K., Edmunds S., Lane G., et al. Identification of urinary biomarkers of colon inflammation in IL10-/- mice using short-column LCMS metabolomics. J Biomed Biotechnol 2011, 2011:974701.
72. Shiomi Y., Nishiumi S., Ooi M., Hatano N., Shinohara M., Yoshie T., et al. GCMS-based metabolomic study in mice with colitis induced by dextran sulfate sodium. Inflamm Bowel Dis 2011, [Epub ahead of print].
73. Hirayama A., Kami K., Sugimoto M., Sugawara M., Toki N., Onozuka H., et al. Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res 2009, 69:4918-4925.
74. Denkert C., Budczies J., Weichert W., Wohlgemuth G., Scholz M., Kind T., et al. Metabolite profiling of human colon carcinoma - deregulation of TCA cycle and amino acid turnover. Mol Cancer 2008, 7:72.
75. Monleón D., Morales J.M., Barrasa A., López J.A., Vázquez C., Celda B. Metabolite profiling of fecal water extracts from human colorectal cancer. NMR Biomed 2009, 22:342-348.
76. Fan T.W., Lane A.N., Higashi R.M., Farag M.A., Gao H., Bousamra M., et al. Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM). Mol Cancer 2009, 8:41.
77. Wu H., Xue R., Lu C., Deng C., Liu T., Zeng H., et al. Metabolomic study for diagnostic model of oesophageal cancer using gas chormatography/mass spectrometry. J Chromatogr B 2009, 877:3111-3117.
78. Woo H.M., Kim K.M., Choi M.H., Jung B.H., Lee J., Kong G., et al. Mass spectrometry based metabolomic approaches in urinary biomarker study of women's cancers. Clin Chim Acta 2009, 400:63-69.
79. Yan S., Wei B.J., Lin Z., Yang Y., Zhou Z.T., Zhang W. A metabonomic approach to the diagnosis of oral squamous cell carcinoma, oral lichen planus and oral leukoplakia. Oral Oncol 2008, 44:477-483.
80. Slupsky C.M., Steed H., Wells T.H., Dabbs K., Schepansky A., Capstick V., et al. Urine metabolite analysis offers potential early diagnosis of ovarian and breast cancers. Clin Cancer Res 2010, 16:5835-5841.
81. Bathe O.F., Shaykhutdinov R., Kopciuk K., Weljie A.M., McKay A., Sutherland F.R., et al. Feasibility of identifying pancreatic cancer based on serum metabolomics. Cancer Epidemiol Biomarkers Prev 2011, 20:140-147.
82. Chen J.L., Tang H.Q., Hu J.D., Fan J., Hong J., Gu J.Z. Metabolomics of gastric cancer metastasis detected by gas chromatography and mass spectrometry. World J Gastroenterol 2010, 16:5874-5880.
83. Slupsky C.M., Cheypesh A., Chao D.V., Fu H., Rankin K.N., Marrie T.J., et al. Streptococcus pneumoniae and Staphylococcus aureus pneumonia induce distinct metabolic responses. J Proteome Res 2009, 8:3029-3036.
84. Slupsky C.M., Rankin K.N., Fu H., Chang D., Rowe B.H., Charles P.G.P., et al. Pneumococcal pneumonia: potential for diagnosis through a urinary metabolic profile. J Proteome Res 2009, 8:5550-5558.
85. Wikoff W.R., Kalisak E., Trauger S., Manchester M., Siuzdak G. Response and recovery in the plasma metabolome tracks the acute LCMV-induced immune response. J Proteome Res 2009, 8:3578-3587.
86. Kuhara T., Ohse M., Inoue Y., Shinka T., Okano Y., Shintaku H., et al. Urinary metabolic profile of phenylketonuria in patients receiving total parenteral nutrition and medication. Rapid Commun Mass Spectrom 2009, 23:3167-3172.
87. German J.B., Hammock B.D., Watkins S.M. Metabolomics: building on a century of biochemistry to guide human health. Metabolomics 2005, 1:3-9.
88. Wishart D.S., Tzur D., Knox C., Eisner R., Guo A.C., Young N., et al. HMDB: the Human Metabolome Database. Nucleic Acids Res 2008, 35:D521-D526.
89. Goodacre R. Metabolomics of a superorganism. J Nutr 2007, 137:259S-266S.