Hydroquinone Stimulates Inflammatory Functions in Microvascular Endothelial Cells via NF-κB Nuclear Activation

Basic and Clinical Pharmacology and Toxicology

Volumn 109, Issue 5, 2011, Pages 372-380

  Hebeda, Cristina Bichels ^a   Pinedo, Fernanda Júdice ^a   Vinolo, Marco Aurélio Ramirez ^a   Curi, Rui ^a   Farsky, Sandra Helena Poliselli ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; CELL ADHESION MOLECULE; CYTOCHROME P450 2E1; HYDROQUINONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; PROSTAGLANDIN SYNTHASE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL FUNCTION; CREMASTER MUSCLE; ENDOTHELIUM CELL; ENZYME ACTIVATION; IMMUNE RESPONSE; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTIGENS, CD31; BENZOQUINONES; CELL ADHESION MOLECULES; CELLS, CULTURED; CYTOCHROME P-450 CYP2E1; ENDOTHELIAL CELLS; HYDROQUINONES; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-1BETA; LEUKOCYTES; LIPOPOLYSACCHARIDES; NF-KAPPA B; PEROXIDASE; RATS; RATS, WISTAR; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

RATTUS NORVEGICUS;

EID: 80054070903     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2011.00739.x     Document Type: Article

References (50)

1. McGregor D. Hydroquinone: an evaluation of the human risks from its carcinogenic and mutagenic properties. Crit Rev Toxicol 2007;37:887-914.
2. Deisinger PJ, Hill TS, English JC. Human exposure to naturally occurring hydroquinone. J Toxicol Environ Health 1996;47:31-46.
3. Descatha A, Jenabian A, Conso F, Ameille J. Occupational exposures and haematological malignancies: overview on human recent data. Cancer Causes Control 2005;16:939-53.
4. DeCaprio AP. The toxicology of hydroquinone-relevance to occupational and environmental exposure. Crit Rev Toxicol 1999;29:283-330.
5. Gut I, Nedelcheva V, Soucek P, Stopka P, Vodicka P, Gelboin HV et al. The role of CYP2E1 and 2B1 in metabolic activation of benzene derivatives. Arch Toxicol 1996;71:45-56.
6. Ganousis LG, Goon D, Zyglewska T, Wu KK, Ross D. Cell-specific metabolism in mouse bone marrow stroma: studies of activation and detoxification of benzene metabolites. Mol Pharmacol 1992;42:1118-25.
7. Piccoli P, Carrieri M, Padovano L, Di Mare M, Bartolucci GB, Fracasso ME et al. In vivo CYP2E1 phenotyping as a new potential biomarker of occupational and experimental exposure to benzene. Toxicol Lett 2010;192:29-33.
8. Macedo SM, Lourenço EL, Borelli P, Fock RA, Ferreira JM Jr, Farsky SH. Effect of in vivo phenol or hydroquinone exposure on events related to neutrophils delivery during an inflammatory response. Toxicology 2006;220:126-35.
9. Macedo SM, Vaz SC, Lourenço EL, de Sousa Mda G, Ligeiro-Oliveira AP, Ferreira JM Jr et al. In vivo hydroquinone exposure impairs allergic lung inflammation in rats. Toxicology 2007;241:47-57.
10. Cho JY. Suppressive effect of hydroquinone, a benzene metabolite, on in vitro inflammatory responses mediated by macrophages, monocytes, and lymphocytes. Mediators Inflamm 2008; 2008: Article ID: 298010.
11. Kim AR, Cho JY, Lee JY, Choi JS, Chung HY. Hydroquinone modulates reactivity of peroxynitrite and nitric oxide production. J Pharm Pharmacol 2005;57:475-81.
12. Hedli CC, Rao NR, Reuhl KR, Witmer CM, Snyder R. Effects of benzene metabolite treatment on granulocytic differentiation and DNA adduct formation in HL-60 cells. Arch Toxicol 1996;70:135-44.
13. Gates PE, Strain WD, Shore AC. Human endothelial function and microvascular ageing. Exp Physiol 2009;94:311-6.
14. Muller WA. Mechanisms of transendothelial migration of leukocytes. Circ Res 2009;105:223-30.
15. Langer HF, Chavakis T. Leukocyte-endothelial interactions in inflammation. J Cell Mol Med 2009;13:1211-20.
16. Rao RM, Yang L, Garcia-Cardena G, Luscinskas FW. Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall. Circ Res 2007;101:234-47.
17. Muller WA. Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. Trends Immunol 2003;24:327-34.
18. Cook-Mills JM, Deem TL. Active participation of endothelial cells in inflammation. J Leukoc Biol 2005;77:487-95.
19. Hordijk PL. Endothelial signalling events during leukocyte transmigration. FEBS J 2006;273:4408-15.
20. Bing RJ, Saeed M, Hartmann A. The vasodilator effect of coronary vascular endothelium in situ: its inactivation by hydroquinone. J Mol Cell Cardiol 1987;19:343-8.
21. Bironaite D, Siegel D, Moran JL, Weksler BB, Ross D. Stimulation of endothelial IL-8 (eIL-8) production and apoptosis by phenolic metabolites of benzene in HL-60 cells and human bone marrow endothelial cells. Chem Biol Interact 2004;149:177-88.
22. Zhou H, Kepa JK, Siegel D, Miura S, Hiraki Y, Ross D. Benzene metabolite hydroquinone up-regulates chondromodulin-I and inhibits tube formation in human bone marrow endothelial cells. Mol Pharmacol 2009;76:579-87.
23. Chen SF, Fei X, Li SH. A new simple method for isolation of microvascular endothelial cells avoiding both chemical and mechanical injuries. Microvasc Res 1995;50:119-28.
24. Lotufo CM, Yamashita CE, Farsky SH, Markus RP. Melatonin effect on endothelial cells reduces vascular permeability increase induced by leukotriene B4. Eur J Pharmacol 2006;534:258-63.
25. Tamura EK, Cecon E, Monteiro AW, Silva CL, Markus RP. Melatonin inhibits LPS-induced NO production in rat endothelial cells. J Pineal Res 2009;46:268-74.
26. Cavalcanti DM, Lotufo CM, Borelli P, Ferreira ZS, Markus RP, Farsky SH. Endogenous glucocorticoids control neutrophil mobilization from bone marrow to blood and tissues in non-inflammatory conditions. Br J Pharmacol 2007;152:1291-300.
27. Silva CL, Tamura EK, Macedo SM, Cecon E, Bueno-Alves L, Farsky SH et al. Melatonin inhibits nitric oxide production by microvascular endothelial cells in vivo and in vitro. Br J Pharmacol 2007;151:195-205.
28. Waismam K, Chudzinski-Tavassi AM, Carrijo-Carvalho LC, Pacheco MT, Farsky SH. Lopap: a non-inflammatory and cytoprotective molecule in neutrophils and endothelial cells. Toxicon 2009;53:652-9.
29. Hebeda CB, Teixeira SA, Tamura EK, Muscará MN, Mello SBV, Markus RP et al. Nitric oxide modulates LPS-induced endothelial PECAM-1 expression via IL-10. Clin Exp Immunol 2011, doi: 10.1111/j.1365-2249.2011.04396x [Epub ahead of print].
30. Chudzinski-Tavassi AM, Carrijo-Carvalho LC, Waismam K, Farsky SH, Ramos OH, Reis CV. A lipocalin sequence signature modulates cell survival. FEBS Lett 2010;584:2896-900.
31. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
32. Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T. Transcriptional regulation of endothelial cell adhesion molecules: NF kappa B and cytokine-inducible enhancers. FASEB J 1995;9:899-909.
33. Schlosser MJ, Kalf GF. Metabolic activation of hydroquinone by macrophage peroxidase. Chem Biol Interact 1989;72:191-207.
34. Kettle AJ, Winterbourn CC. Oxidation of hydroquinone by myeloperoxidase. Mechanism of stimulation by benzoquinone. J Biol Chem 1992;267:8319-24.
35. Yoon BI, Hirabayashi Y, Kawasaki Y, Kodama Y, Kaneko T, Kanno J et al. Aryl hydrocarbon receptor mediates benzene-induced hematotoxicity. Toxicol Sci 2002;70:150-6.
36. Hirschi KK, D'Amore PA. Pericytes in the microvasculature. Cardiovasc Res 1996;32:687-98.
37. Chakravarthy U, Gardiner TA. Endothelium-derived agents in pericyte function/dysfunction. Prog Retin Eye Res 1999;18:511-27.
38. Inayat-Hussain SH, Ross D. Intrinsic pathway of hydroquinone induced apoptosis occurs via both caspase-dependent and caspase-independent mechanisms. Chem Res Toxicol 2005;18:420-7.
39. Shen DX, Shi X, Fu JL, Zhang YM, Zhou ZC. The role of thiol reduction in hydroquinone-induced apoptosis in HEK293 cells. Chem Biol Interact 2003;145:225-33.
40. Kim YJ, Woo HD, Kim BM, Lee YJ, Kang SJ, Cho YH et al. Risk assessment of hydroquinone: differential responses of cell growth and lethality correlated to hydroquinone concentration. J Toxicol Environ Health A 2009;72:1272-8.
41. Kalf GF, Renz JF, Niculescu R. p-Benzoquinone, a reactive metabolite of benzene, prevents the processing of pre-interleukins-1 alpha and -1 beta to active cytokines by inhibition of the processing enzymes, calpain, and interleukin-1 beta converting enzyme. Environ Health Perspect 1996;104:1251-6.
42. Niculescu R, Bradford HN, Colman RW, Kalf GF. Inhibition of the conversion of pre-interleukins-1 alpha and 1 beta to mature cytokines by p-benzoquinone, a metabolite of benzene. Chem Biol Interact 1995;98:211-22.
43. Carbonnelle P, Lison D, Leroy JY, Lauwerys R. Effect of the benzene metabolite, hydroquinone, on interleukin-1 secretion by human monocytes in vitro. Toxicol Appl Pharmacol 1995;132:220-6.
44. Pyatt DW, Yang Y, Stillman WS, Cano LL, Irons RD. Hydroquinone inhibits PMA-induced activation of NFκB in primary human CD19+ B lymphocytes. Cell Biol Toxicol 2000;16:41-51.
45. Ma Q, Kinneer K. Chemoprotection by phenolic antioxidants. Inhibition of tumor necrosis factor alpha induction in macrophages. J Biol Chem 2002;277:2477-84.
46. Ma Q, Kinneer K, Ye J, Chen BJ. Inhibition of nuclear factor κB by phenolic antioxidants: interplay between antioxidant signaling and inflammatory cytokine expression. Mol Pharmacol 2003;64:211-9.
47. Eling TE, Thompson DC, Foureman GL, Curtis JF, Hughes MF. Prostaglandin H synthase and xenobiotic oxidation. Annu Rev Pharmacol Toxicol 1990;30:1-45.
48. Lee JY, Kim JY, Lee YG, Shin WC, Chun T, Rhee MH et al. Hydroquinone, a reactive metabolite of benzene, reduces macrophage-mediated immune responses. Mol Cells 2007;23:198-206.
49. Lee JY, Lee YG, Lee J, Yang KJ, Kim AR, Kim JY et al. Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects. J Biol Chem 2010;285:9932-48.
50. Zheng JH, Pyatt DW, Gross SA, Le AT, Kerzic PJ, Irons RD. Hydroquinone modulates the GM-CSF signaling pathway in TF-1 cells. Leukemia 2004;18:1296-304.