Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects

Journal of Biological Chemistry

Volumn 285, Issue 13, 2010, Pages 9932-9948

  Lee, Ji Yeon ^a   Lee, Yong Gyu ^a   Lee, Jaehwi ^b   Yang, Keum Jin ^c   Kim, Ae Ra ^a   Kim, Joo Young ^a   Won, Moo Ho ^d   Park, Jongsun ^c   Yoo, Byong Chul ^e   Kim, Sanghee ^f   Cho, Won Jea ^g   Cho, Jae Youl ^a  

^a Kangwon National University   (South Korea)

^b Chung Ang University   (South Korea)

^c Chungnam National University   (South Korea)

^d Hallym University   (South Korea)

^e National Cancer Center   (South Korea)

^f Seoul National University   (South Korea)

^g Chonnam National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE DERIVATIVES; CYTOKINE GENES; DIETARY COMPONENTS; IMMUNOSUPPRESSIVE DRUGS; IMMUNOSUPPRESSIVE EFFECTS; INFLAMMATORY RESPONSE; MERCAPTOETHANOL; MOLECULAR TARGETS; PATTERN RECOGNITION RECEPTORS; PROTEIN KINASE B; REGULATORY MECHANISM; SULFHYDRYL GROUPS; TARGET SITES; TRANSLOCATION PATHWAY; TUMORIGENESIS;

BENZENE; GENE EXPRESSION; HYDROXYLATION; KETONES; LAWS AND LEGISLATION; PATTERN RECOGNITION; PHENOLS; PHOSPHORYLATION;

TARGETS;

CYTOKINE; HYDROQUINONE; HYDROQUINONE DERIVATIVE; I KAPPA B ALPHA; I KAPPA B ALPHA KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MERCAPTOETHANOL; NITRIC OXIDE; PATTERN RECOGNITION RECEPTOR; PHOSPHOTRANSFERASE; PROTEIN KINASE B; SERINE; THIOL GROUP; THREONINE; UNCLASSIFIED DRUG; BENZENE; CYSTEINE; IMMUNOSUPPRESSIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG TARGETING; EAR DISEASE; EDEMA; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IC 50; IMMUNOMODULATION; IMMUNOPHARMACOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; INHIBITION KINETICS; LIQUID CHROMATOGRAPHY; LIVER PARENCHYMA; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPTIC SHOCK; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CHEMISTRY; CONFOCAL MICROSCOPY; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; METHODOLOGY;

ANIMALS; BENZENE; CHROMATOGRAPHY, LIQUID; CYSTEINE; HYDROQUINONES; IMMUNOSUPPRESSIVE AGENTS; INHIBITORY CONCENTRATION 50; MALE; MASS SPECTROMETRY; MERCAPTOETHANOL; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; MICROSCOPY, CONFOCAL; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 77951216897     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.074872     Document Type: Article

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