In vivo CYP2E1 phenotyping as a new potential biomarker of occupational and experimental exposure to benzene

Toxicology Letters

Volumn 192, Issue 1, 2010, Pages 29-33

  Piccoli, P ^a   Carrieri, M ^b   Padovano, L ^a   Di Mare, M ^a   Bartolucci, G B ^b   Fracasso, M E ^c   Lepera, J S ^d   Manno, M ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY OF VERONA   (Italy)

^d SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

6 OH chlorzoxazone; Benzene; Chlorzoxazone; CYP2E1; Metabolic phenotype

Indexed keywords

6 HYDROXYCHLORZOXAZONE; BENZENE; BIOLOGICAL MARKER; CHLORZOXAZONE; CORN OIL; CYTOCHROME P450 2E1; MACROGOL; MUCONIC ACID; PHENYLMERCAPTURIC ACID; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ARTICLE; BIOLOGICAL MONITORING; CHEMICAL MODIFICATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DISPOSITION; ENZYME ACTIVITY; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; MALE; NONHUMAN; OCCUPATIONAL EXPOSURE; OCCUPATIONAL TOXICOLOGY; PETROCHEMICAL INDUSTRY; PHENOTYPE; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TOXICITY TESTING; VENOUS BLOOD;

ACETYLCYSTEINE; ANIMALS; AREA UNDER CURVE; BENZENE; BIOLOGICAL MARKERS; CHLORZOXAZONE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2E1; HUMANS; MALE; OCCUPATIONAL EXPOSURE; PHENOTYPE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SORBIC ACID; STATISTICS, NONPARAMETRIC;

ANIMALIA; RATTUS; ZEA MAYS;

EID: 72949102629     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.10.023     Document Type: Article

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