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Volumn 71, Issue 20, 2011, Pages 6438-6449

Enhancement of TGF-β signaling responses by the E3 ubiquitin ligase Arkadia provides tumor suppression in colorectal cancer

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; ARKADIA; AZOXYMETHANE; BETA CATENIN; COMPLEMENTARY DNA; DEXTRAN SULFATE; MESSENGER RNA; SMAD2 PROTEIN; SMALL NUCLEOLAR RIBONUCLEOPROTEIN; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 80054044729     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-1645     Document Type: Article
Times cited : (34)

References (42)
  • 1
    • 77951625831 scopus 로고    scopus 로고
    • Colorectal cancer: National and international perspective on the burden of disease and public health impact
    • Gellad ZF, Provenzale D. Colorectal cancer: national and international perspective on the burden of disease and public health impact. Gastroenterology 2010;138:2177-90.
    • (2010) Gastroenterology , vol.138 , pp. 2177-2190
    • Gellad, Z.F.1    Provenzale, D.2
  • 2
    • 30944444113 scopus 로고    scopus 로고
    • Alterations in components of the TGF-beta superfamily signaling pathways in human cancer
    • DOI 10.1016/j.cytogfr.2005.09.009, PII S1359610105001139
    • Levy L, Hill CS. Alterations in components of the TGF-beta superfamily signaling pathways in human cancer. Cytokine Growth Factor Rev 2006;17:41-58. (Pubitemid 43117515)
    • (2006) Cytokine and Growth Factor Reviews , vol.17 , Issue.1-2 , pp. 41-58
    • Levy, L.1    Hill, C.S.2
  • 3
    • 34547789841 scopus 로고    scopus 로고
    • TGF-beta signaling alterations and susceptibility to colorectal cancer
    • DOI 10.1093/hmg/ddl486, Cancer Genetics
    • Xu Y, Pasche B. TGF-beta signaling alterations and susceptibility to colorectal cancer. Hum Mol Genet 2007;16:R14-20. (Pubitemid 47241839)
    • (2007) Human Molecular Genetics , vol.16 , Issue.R1
    • Xu, Y.1    Pasche, B.2
  • 6
    • 77952896646 scopus 로고    scopus 로고
    • TGFbeta signalling: A complex web in cancer progression
    • Ikushima H, Miyazono K. TGFbeta signalling: a complex web in cancer progression. Nat Rev Cancer 2010;10:415-24.
    • (2010) Nat Rev Cancer , vol.10 , pp. 415-424
    • Ikushima, H.1    Miyazono, K.2
  • 7
    • 27644494876 scopus 로고    scopus 로고
    • Smad transcription factors
    • DOI 10.1101/gad.1350705
    • Massague J, Seoane J, Wotton D. Smad transcription factors. Genes Dev 2005;19:2783-810. (Pubitemid 41739965)
    • (2005) Genes and Development , vol.19 , Issue.23 , pp. 2783-2810
    • Massague, J.1    Seoane, J.2    Wotton, D.3
  • 8
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and versatility in TGF-beta signaling through smads
    • DOI 10.1146/annurev.cellbio.21.022404.142018
    • Feng XH, Derynck R. Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol 2005;21:659-93. (Pubitemid 41740650)
    • (2005) Annual Review of Cell and Developmental Biology , vol.21 , pp. 659-693
    • Feng, X.-H.1    Derynck, R.2
  • 10
    • 61749097816 scopus 로고    scopus 로고
    • Tgf-beta superfamily signaling in embryonic development and homeostasis
    • Wu MY, Hill CS. Tgf-beta superfamily signaling in embryonic development and homeostasis. Dev Cell 2009;16:329-43.
    • (2009) Dev Cell , vol.16 , pp. 329-343
    • Wu, M.Y.1    Hill, C.S.2
  • 11
    • 70450187617 scopus 로고    scopus 로고
    • The regulation of TGFbeta signal transduction
    • Moustakas A, Heldin CH. The regulation of TGFbeta signal transduction. Development 2009;136:3699-714.
    • (2009) Development , vol.136 , pp. 3699-3714
    • Moustakas, A.1    Heldin, C.H.2
  • 13
    • 58149239731 scopus 로고    scopus 로고
    • Ski and SnoN, potent negative regulators of TGF-beta signaling
    • Deheuninck J, Luo K. Ski and SnoN, potent negative regulators of TGF-beta signaling. Cell Res 2009;19:47-57.
    • (2009) Cell Res , vol.19 , pp. 47-57
    • Deheuninck, J.1    Luo, K.2
  • 15
    • 34548238145 scopus 로고    scopus 로고
    • Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation
    • DOI 10.1128/MCB.00664-07
    • Levy L, Howell M, Das D, Harkin S, Episkopou V, Hill CS. Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Mol Cell Biol 2007;27:6068-83. (Pubitemid 47326695)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.17 , pp. 6068-6083
    • Levy, L.1    Howell, M.2    Das, D.3    Harkin, S.4    Episkopou, V.5    Hill, C.S.6
  • 17
    • 33646132747 scopus 로고    scopus 로고
    • Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia
    • Liu W, Rui H, Wang J, Lin S, He Y, Chen M, et al. Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J 2006;25:1646-58.
    • (2006) EMBO J , vol.25 , pp. 1646-1658
    • Liu, W.1    Rui, H.2    Wang, J.3    Lin, S.4    He, Y.5    Chen, M.6
  • 18
    • 44849143723 scopus 로고    scopus 로고
    • Transforming growth factor-beta suppresses the ability of Ski to inhibit tumor metastasis by inducing its degradation
    • Le Scolan E, Zhu Q,WangL, Bandyopadhyay A, Javelaud D, Mauviel A, et al. Transforming growth factor-beta suppresses the ability of Ski to inhibit tumor metastasis by inducing its degradation. Cancer Res 2008;68:3277-85.
    • (2008) Cancer Res , vol.68 , pp. 3277-3285
    • Le Scolan, E.1    Zhu, Q.2    Wang, L.3    Bandyopadhyay, A.4    Javelaud, D.5    Mauviel, A.6
  • 19
    • 77950600392 scopus 로고    scopus 로고
    • Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells
    • Nagano Y, Koinuma D, Miyazawa K, Miyazono K. Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells. J Biochem 2010;147:545-54.
    • (2010) J Biochem , vol.147 , pp. 545-554
    • Nagano, Y.1    Koinuma, D.2    Miyazawa, K.3    Miyazono, K.4
  • 21
    • 0035848835 scopus 로고    scopus 로고
    • Induction of the mammalian node requires Arkadia function in the extraembryonic lineages
    • DOI 10.1038/35071095
    • Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL, Swan D. Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. Nature 2001;410:825-30. (Pubitemid 32303782)
    • (2001) Nature , vol.410 , Issue.6830 , pp. 825-830
    • Episkopou, V.1    Arkell, R.2    Timmons, P.M.3    Walsh, J.J.4    Andrew, R.L.5    Swan, D.6
  • 22
    • 0035848854 scopus 로고    scopus 로고
    • Arkadia enhances nodal-related signalling to induce mesendoderm
    • DOI 10.1038/35071103
    • Niederlander C, Walsh JJ, Episkopou V, Jones CM. Arkadia enhances nodal-related signalling to induce mesendoderm. Nature 2001;410:830-4. (Pubitemid 32303783)
    • (2001) Nature , vol.410 , Issue.6830 , pp. 830-834
    • Niederlander, C.1    Walsh, J.J.2    Episkopou, V.3    Jones, C.M.4
  • 25
    • 29744446515 scopus 로고    scopus 로고
    • ILK over-expression in human colon cancer progression correlates with activation of beta-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway
    • DOI 10.1002/path.1860
    • Bravou V, Klironomos G, Papadaki E, Taraviras S, Varakis J. ILK overexpression in human colon cancer progression correlates with activation of beta-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway. J Pathol 2006;208:91-9. (Pubitemid 43025707)
    • (2006) Journal of Pathology , vol.208 , Issue.1 , pp. 91-99
    • Bravou, V.1    Klironomos, G.2    Papadaki, E.3    Taraviras, S.4    Varakis, J.5
  • 27
    • 84857113333 scopus 로고    scopus 로고
    • Available from: [cited 2011 Sept 20]
    • Wellcome Trust Sanger Institute. Available from: http://www.sanger.ac.uk/ search?db=cosmic&t=RNF111 [cited 2011 Sept 20].
  • 28
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006;127:469-80.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 29
    • 34247221487 scopus 로고    scopus 로고
    • The Forkhead Box M1 Transcription Factor Contributes to the Development and Growth of Mouse Colorectal Cancer
    • DOI 10.1053/j.gastro.2007.01.036, PII S0016508507001746
    • Yoshida Y, Wang IC, Yoder HM, Davidson NO, Costa RH. The forkhead box M1 transcription factor contributes to the development and growth of mouse colorectal cancer. Gastroenterology 2007;132:1420-31. (Pubitemid 46627572)
    • (2007) Gastroenterology , vol.132 , Issue.4 , pp. 1420-1431
    • Yoshida, Y.1    Wang, I.2    Yoder, H.M.3    Davidson, N.O.4    Costa, R.H.5
  • 30
    • 0344237231 scopus 로고    scopus 로고
    • A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate
    • DOI 10.1111/j.1349-7006.2003.tb01386.x
    • Tanaka T, Kohno H, Suzuki R, Yamada Y, Sugie S, Mori H. A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. Cancer Sci 2003;94:965-73. (Pubitemid 37508979)
    • (2003) Cancer Science , vol.94 , Issue.11 , pp. 965-973
    • Tanaka, T.1    Kohno, H.2    Suzuki, R.3    Yamada, Y.4    Sugie, S.5    Mori, H.6
  • 31
    • 0030849321 scopus 로고    scopus 로고
    • Assessment of mutations in Ki-ras and p53 in colon cancers from azoxymethane- and dimethylhydrazine-treated rats
    • DOI 10.1002/(SICI)1098-2744(199707)19:2<137::AID-MC8>3.0.CO;2-C
    • Erdman SH, Wu HD, Hixson LJ, Ahnen DJ, Gerner EW. Assessment of mutations in Ki-ras and p53 in colon cancers from azoxymethane- and dimethylhydrazine- treated rats. Mol Carcinog 1997;19:137-44. (Pubitemid 27296744)
    • (1997) Molecular Carcinogenesis , vol.19 , Issue.2 , pp. 137-144
    • Erdman, S.H.1    Wu, H.D.2    Hixson, L.J.3    Ahnen, D.J.4    Gerner, E.W.5
  • 32
    • 0034122380 scopus 로고    scopus 로고
    • Frequent mutations of the beta-catenin gene in mouse colon tumors induced by azoxymethane
    • Takahashi M, Nakatsugi S, Sugimura T, Wakabayashi K. Frequent mutations of the beta-catenin gene in mouse colon tumors induced by azoxymethane. Carcinogenesis 2000;21:1117-20. (Pubitemid 30389335)
    • (2000) Carcinogenesis , vol.21 , Issue.6 , pp. 1117-1120
    • Takahashi, M.1    Nakatsugi, S.2    Sugimura, T.3    Wakabayashi, K.4
  • 33
    • 6444237027 scopus 로고    scopus 로고
    • Loss of heterozygosity and nonsense mutation in Apc in azoxymethane-induced colonic tumours in Min mice
    • Mollersen L, Paulsen JE, Alexander J. Loss of heterozygosity and nonsense mutation in Apc in azoxymethane-induced colonic tumours in min mice. Anticancer Res 2004;24:2595-9. (Pubitemid 39407133)
    • (2004) Anticancer Research , vol.24 , Issue.5 A , pp. 2595-2599
    • Mollersen, L.1    Paulsen, J.E.2    Alexander, J.3
  • 34
    • 0031410991 scopus 로고    scopus 로고
    • AOM-induced mouse colon tumors do not express full-length APC protein
    • DOI 10.1093/carcin/18.12.2435
    • Maltzman T, Whittington J, Driggers L, Stephens J, Ahnen D. AOM-induced mouse colon tumors do not express full-length APC protein. Carcinogenesis 1997;18:2435-9. (Pubitemid 28134660)
    • (1997) Carcinogenesis , vol.18 , Issue.12 , pp. 2435-2439
    • Maltzman, T.1    Whittington, J.2    Driggers, L.3    Stephens, J.4    Ahnen, D.5
  • 36
    • 0032499789 scopus 로고    scopus 로고
    • Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members
    • DOI 10.1073/pnas.95.12.6733
    • Moustakas A, Kardassis D. Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members. Proc Natl Acad Sci U S A 1998;95:6733-8. (Pubitemid 28278049)
    • (1998) Proceedings of the National Academy of Sciences of the United States of America , vol.95 , Issue.12 , pp. 6733-6738
    • Moustakas, A.1    Kardassis, D.2
  • 39
    • 0034277144 scopus 로고    scopus 로고
    • Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice
    • Taketo MM, Takaku K. Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice. Hum Cell 2000;13:85-95.
    • (2000) Hum Cell , vol.13 , pp. 85-95
    • Taketo, M.M.1    Takaku, K.2
  • 40
    • 58349120416 scopus 로고    scopus 로고
    • Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development
    • Zeng Q, Phukan S, Xu Y, Sadim M, Rosman DS, Pennison M, et al. Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development. Cancer Res 2009;69:678-86.
    • (2009) Cancer Res , vol.69 , pp. 678-686
    • Zeng, Q.1    Phukan, S.2    Xu, Y.3    Sadim, M.4    Rosman, D.S.5    Pennison, M.6
  • 41
    • 0032489508 scopus 로고    scopus 로고
    • Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes
    • DOI 10.1016/S0092-8674(00)81132-0
    • Takaku K, Oshima M, Miyoshi H, Matsui M, Seldin MF, Taketo MM. Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell 1998;92:645-56. (Pubitemid 28141513)
    • (1998) Cell , vol.92 , Issue.5 , pp. 645-656
    • Takaku, K.1    Oshima, M.2    Miyoshi, H.3    Matsui, M.4    Seldin, M.F.5    Taketo, M.M.6
  • 42
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in cancer
    • Massague J. TGFbeta in cancer. Cell 2008;134:215-30.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1


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