메뉴 건너뛰기




Volumn 116, Issue SUPPL. 11, 2010, Pages 2768-2782

Characterization of the roles of RHOC and RHOA GTPases in invasion, motility, and matrix adhesion in inflammatory and aggressive breast cancers

Author keywords

Adhesion; Invasion; Motility; RHOA; RHOC

Indexed keywords

ALPHA2 INTEGRIN; BETA1 INTEGRIN; COLLAGEN TYPE 1; GUANINE NUCLEOTIDE BINDING PROTEIN; MATRIGEL; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RHOC GUANINE NUCLEOTIDE BINDING PROTEIN; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 2; GUANOSINE TRIPHOSPHATASE; MESSENGER RNA; RHOC PROTEIN;

EID: 77952709202     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.25181     Document Type: Conference Paper
Times cited : (59)

References (56)
  • 1
    • 6344231714 scopus 로고    scopus 로고
    • Why 3 Rho proteins? RHOA, RhoB, RHOC, and cell motility
    • Wheeler AP, Ridley AJ. Why 3 Rho proteins? RHOA, RhoB, RHOC, and cell motility. Exp Cell Res. 2004;301:43-49.
    • (2004) Exp Cell Res , vol.301 , pp. 43-49
    • Wheeler, A.P.1    Ridley, A.J.2
  • 3
    • 1642304545 scopus 로고    scopus 로고
    • Altered Rho GTPase signaling pathways in breast cancer cells
    • DOI 10.1023/B:BREA.0000018422.02237.f9
    • Burbelo P, Wellstein A, Pestell RG. Altered Rho GTPase signaling pathways in breast cancer cells. Breast Cancer Res Treat. 2004;84:43-48. (Pubitemid 38388859)
    • (2004) Breast Cancer Research and Treatment , vol.84 , Issue.1 , pp. 43-48
    • Burbelo, P.1    Wellstein, A.2    Pestell, R.G.3
  • 4
    • 0034601487 scopus 로고    scopus 로고
    • Genomic analysis of metastasis reveals an essential role for RHOC
    • Clark EA, Golub TR, Lander ES, Hynes RO. Genomic analysis of metastasis reveals an essential role for RHOC. Nature. 2000;406:532-535.
    • (2000) Nature , vol.406 , pp. 532-535
    • Clark, E.A.1    Golub, T.R.2    Lander, E.S.3    Hynes, R.O.4
  • 6
    • 0031974721 scopus 로고    scopus 로고
    • Overexpression of the RHOC gene correlates with progression of ductal adenocarcinoma of the pancreas
    • Suwa H, Ohshio G, Imamura T, et al. Overexpression of the RHOC gene correlates with progression of ductal adenocarcinoma of the pancreas. Br J Cancer. 1998;77:147-152.
    • (1998) Br J Cancer , vol.77 , pp. 147-152
    • Suwa, H.1    Ohshio, G.2    Imamura, T.3
  • 7
    • 0036168355 scopus 로고    scopus 로고
    • Characterization of RhoC expression in benign and malignant breast disease: A potential new marker for small breast carcinomas with metastatic ability
    • Kleer CG, van Golen KL, Zhang Y, Wu ZF, Rubin MA, Merajver SD. Characterization of RHOC expression in benign and malignant breast disease - a potential new marker for small breast carcinomas with metastatic ability. Am J Pathol. 2002;160:579-584. (Pubitemid 34160335)
    • (2002) American Journal of Pathology , vol.160 , Issue.2 , pp. 579-584
    • Kleer, C.G.1    Van Golen, K.L.2    Zhang, Y.3    Wu, Z.-F.4    Rubin, M.A.5    Merajver, S.D.6
  • 8
    • 25844484093 scopus 로고    scopus 로고
    • RHOC-GTPase is a novel tissue biomarker associated with biologically aggressive carcinomas of the breast
    • Kleer CG, Griffith KA, Sabel MS, et al. RHOC-GTPase is a novel tissue biomarker associated with biologically aggressive carcinomas of the breast. Breast Cancer Res Treat. 2005;93: 101-110.
    • (2005) Breast Cancer Res Treat , vol.93 , pp. 101-110
    • Kleer, C.G.1    Griffith, K.A.2    Sabel, M.S.3
  • 9
    • 0032835343 scopus 로고    scopus 로고
    • A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RHOC GTPase correlate with the inflammatory breast cancer phenotype
    • van Golen KL, Davies S, Wu ZF, et al. A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RHOC GTPase correlate with the inflammatory breast cancer phenotype. Clin Cancer Res. 1999;5:2511-2519.
    • (1999) Clin Cancer Res , vol.5 , pp. 2511-2519
    • Van Golen, K.L.1    Davies, S.2    Wu, Z.F.3
  • 11
    • 0034667370 scopus 로고    scopus 로고
    • RHOC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype
    • van Golen K, Wu ZF, Qiao XT, Bao LW, Merajver SD. RHOC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype. Cancer Res. 2000; 60:5832-5838.
    • (2000) Cancer Res , vol.60 , pp. 5832-5838
    • Van Golen, K.1    Wu, Z.F.2    Qiao, X.T.3    Bao, L.W.4    Merajver, S.D.5
  • 12
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville S, Hall A. Rho GTPases in cell biology. Nature. 2002;420:629-635.
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 14
  • 15
    • 0032034454 scopus 로고    scopus 로고
    • Control of normal mammary epithelial phenotype by integrins
    • Streuli CH, Edwards GM. Control of normal mammary epithelial phenotype by integrins. J Mammary Gland Biol Neoplasia. 1998;3:151-163.
    • (1998) J Mammary Gland Biol Neoplasia , vol.3 , pp. 151-163
    • Streuli, C.H.1    Edwards, G.M.2
  • 16
    • 15444367651 scopus 로고    scopus 로고
    • Integrin engagement differentially modulates epithelial cell motility by RhoA/ROCK and PAK1
    • DOI 10.1074/jbc.M411900200
    • Zhou H, Kramer RH. Integrin engagement differentially modulates epithelial cell motility by RHOA/ROCK and PAK1. J Biol Chem. 2005;280:10624-10635. (Pubitemid 40395924)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.11 , pp. 10624-10635
    • Zhou, H.1    Kramer, R.H.2
  • 17
    • 5044238876 scopus 로고    scopus 로고
    • Integrin signalling during tumour progression
    • Guo W, Giancotti FG. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol. 2004;5:816-826.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 816-826
    • Guo, W.1    Giancotti, F.G.2
  • 18
    • 0025653088 scopus 로고
    • Integrins and tumor invasion
    • Dedhar S. Integrins and tumor invasion. Bioessays. 1990;12: 583-590.
    • (1990) Bioessays , vol.12 , pp. 583-590
    • Dedhar, S.1
  • 19
    • 0027395858 scopus 로고
    • Biology of disease. Role of integrins and other adhesion molecules in tumor progression and metastasis
    • Albelda SM. Biology of disease. Role of integrins and other adhesion molecules in tumor progression and metastasis. Lab Invest. 1993;68:4-17.
    • (1993) Lab Invest , vol.68 , pp. 4-17
    • Albelda, S.M.1
  • 20
    • 0028044834 scopus 로고
    • Signal transduction by integrins and its role in the regulation of tumor growth
    • Juliano R. Signal transduction by integrins and its role in the regulation of tumor growth. Cancer Metastasis Rev. 1994;13:25-30. (Pubitemid 24053337)
    • (1994) Cancer and Metastasis Reviews , vol.13 , Issue.1 , pp. 25-30
    • Juliano, R.1
  • 21
    • 0032034453 scopus 로고    scopus 로고
    • Altered Integrin Expression and the Malignant Phenotype: The Contribution of Multiple Integrated Integrin Receptors
    • Zutter MM, Sun H, Santoro SA. Altered integrin expression and the malignant phenotype: the contribution of multiple integrated integrin receptors. J Mammary Gland Biol Neoplasia. 1998;3:191-200. (Pubitemid 128513230)
    • (1998) Journal of Mammary Gland Biology and Neoplasia , vol.3 , Issue.2 , pp. 191-200
    • Zutter, M.M.1    Sun, H.2    Santoro, S.A.3
  • 23
    • 0028978457 scopus 로고
    • Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells
    • Zutter MM, Santoro SA, Staatz WD, Tsung YL. Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells. Proc Natl Acad Sci USA. 1995;92:7411-7415.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7411-7415
    • Zutter, M.M.1    Santoro, S.A.2    Staatz, W.D.3    Tsung, Y.L.4
  • 24
    • 0028918625 scopus 로고
    • Alteration of collagen-dependent adhesion motility, and morphogenesis by the expression of antisense alpha 2 integrin mRNA in mammary cells
    • Keely P, Fong AM, Zutter MM, Santoro SA. Alteration of collagen-dependent adhesion, motility, and morphogenesis by the expression of antisense alpha 2 integrin mRNA in mammary cells. J Cell Sci. 1995;108:595-607.
    • (1995) J Cell Sci , vol.108 , pp. 595-607
    • Keely, P.1    Fong, A.M.2    Zutter, M.M.3    Santoro, S.A.4
  • 25
    • 0025806141 scopus 로고
    • In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells
    • Chan BMC, Matsuura N, Takada Y, Zetter BR, Hemler ME. In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells. Science. 1991;251:1600-1602.
    • (1991) Science , vol.251 , pp. 1600-1602
    • Chan, B.M.C.1    Matsuura, N.2    Takada, Y.3    Zetter, B.R.4    Hemler, M.E.5
  • 26
    • 0028057470 scopus 로고
    • Suppressed collagen gene expression and induction of alpha 2 beta 1 integrin-type collagen receptor in tumorigenic derivatives of human osteogenic sarcoma (HOS) cell line
    • Santala P, Larjava H, Nissinen L, Riikonen T, Maata A, Heino J. Suppressed collagen gene expression and induction of alpha 2 beta 1 integrin-type collagen receptor in tumorigenic derivatives of human osteogenic sarcoma (HOS) cell line. J Biol Chem. 1994;269:1276-1283.
    • (1994) J Biol Chem , vol.269 , pp. 1276-1283
    • Santala, P.1    Larjava, H.2    Nissinen, L.3    Riikonen, T.4    Maata, A.5    Heino, J.6
  • 27
    • 0029671043 scopus 로고    scopus 로고
    • The expression of integrin alpha 2 beta 1 and attachment to type I collagen of melanoma cells are preferentially induced by tumour promoter, TPA (12-O-tetradecanoyl phorbol-13-acetate)
    • Eguchi H, Horikoshi T. The expression of integrin alpha 2 beta 1 and attachment to type I collagen of melanoma cells are preferentially induced by tumour promoter, TPA (12-O-tetradecanoyl phorbol-13-acetate). Br J Dermatol. 1996;134: 33-39.
    • (1996) Br J Dermatol , vol.134 , pp. 33-39
    • Eguchi, H.1    Horikoshi, T.2
  • 28
    • 0032566265 scopus 로고    scopus 로고
    • Transcription of alpha 2 integrin gene in osteosarcoma cells is enhanced by tumor promoters
    • Nissinen L, Westermarck J, Koivisto L, Kahari VM, Heino J. Transcription of alpha 2 integrin gene in osteosarcoma cells is enhanced by tumor promoters. Exp Cell Res. 1998; 243:1-10.
    • (1998) Exp Cell Res , vol.243 , pp. 1-10
    • Nissinen, L.1    Westermarck, J.2    Koivisto, L.3    Kahari, V.M.4    Heino, J.5
  • 29
    • 0032521857 scopus 로고    scopus 로고
    • Perturbation of beta1-integrin function alters the development of murine mammary gland
    • Faraldo MM, Deugnier M-A, Lukashev M, Thiery JP, Glukhova MA. Perturbation of beta1-integrin function alters the development of murine mammary gland. EMBO J. 1998;17:2139-2147.
    • (1998) EMBO J , vol.17 , pp. 2139-2147
    • Faraldo, M.M.1    Deugnier, M.-A.2    Lukashev, M.3    Thiery, J.P.4    Glukhova, M.A.5
  • 30
    • 21244502580 scopus 로고    scopus 로고
    • Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli
    • Li N, Zhang Y, Naylor MJ, et al. Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli. EMBO J. 2005;24:1942-1953.
    • (2005) EMBO J , vol.24 , pp. 1942-1953
    • Li, N.1    Zhang, Y.2    Naylor, M.J.3
  • 31
    • 5144235557 scopus 로고    scopus 로고
    • Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction
    • White DE, Kurpios NA, Zuo D, et al. Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer Cell. 2004;6:159-170.
    • (2004) Cancer Cell , vol.6 , pp. 159-170
    • White, D.E.1    Kurpios, N.A.2    Zuo, D.3
  • 32
  • 33
    • 13244275005 scopus 로고    scopus 로고
    • Integrin beta1 is required for the invasive behaviour but not proliferation of squamous cell carcinoma cells in vivo
    • DOI 10.1038/sj.bjc.6602255
    • Brockbank EC, Bridges J, Marshall CJ, Sahai E. Integrin beta1 is required for the invasive behaviour but not proliferation of squamous cell carcinoma cells in vivo. Br J Cancer. 2005;92:102-112. (Pubitemid 40188442)
    • (2005) British Journal of Cancer , vol.92 , Issue.1 , pp. 102-112
    • Brockbank, E.C.1    Bridges, J.2    Marshall, C.J.3    Sahai, E.4
  • 34
    • 0042196118 scopus 로고    scopus 로고
    • A role for alphabeta1 integrins in focal adhesion function and polarized cytoskeletal dynamics
    • DOI 10.1016/S1534-5807(03)00261-2, PII S1534580703002612
    • Raghavan S, Vaezi A, Fuchs E. A role for alphabeta1 integrins in focal adhesion function and polarized cytoskeletal dynamics. Dev Cell. 2003;5:415-427. (Pubitemid 37107671)
    • (2003) Developmental Cell , vol.5 , Issue.3 , pp. 415-427
    • Raghavan, S.1    Vaezi, A.2    Fuchs, E.3
  • 35
    • 1642268839 scopus 로고    scopus 로고
    • RhoC induces differential expression of genes involved in invasion and metastasis in MCF10A breast cells
    • DOI 10.1023/B:BREA.0000018426.76893.21
    • Wu M, Wu ZF, Kumar-Sinha C, Chinnaiyan A, Merajver SD. RHOC induces differential expression of genes involved in invasion and metastasis in MCF10A breast cells. Breast Cancer Res Treat. 2004;84:3-12. (Pubitemid 38388855)
    • (2004) Breast Cancer Research and Treatment , vol.84 , Issue.1 , pp. 3-12
    • Wu, M.1    Wu, Z.-F.2    Kumar-Sinha, C.3    Chinnaiyan, A.4    Merajver, S.D.5
  • 36
    • 0037048326 scopus 로고    scopus 로고
    • Rho GTPases in human breast tumours: Expression and mutation analyses and correlation with clinical parameters
    • Fritz G, Brachetti C, Bahlmann F, Schmidt M, Kaina B. Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Br J Cancer. 2002;87:635-644.
    • (2002) Br J Cancer , vol.87 , pp. 635-644
    • Fritz, G.1    Brachetti, C.2    Bahlmann, F.3    Schmidt, M.4    Kaina, B.5
  • 38
    • 0032784388 scopus 로고    scopus 로고
    • Distinct actions and cooperative roles of ROCK and mDia in Rho small G protein-induced reorganization of the actin cytoskeleton in Madin-Darby canine kidney cells
    • Nakano K, Takaishi K, Kodama A, et al. Distinct actions and cooperative roles of ROCK and mDia in Rho small G protein-induced reorganization of the actin cytoskeleton in Madin-Darby canine kidney cells. Mol Biol Cell. 1999; 10:2481-2491. (Pubitemid 29393504)
    • (1999) Molecular Biology of the Cell , vol.10 , Issue.8 , pp. 2481-2491
    • Nakano, K.1    Takaishi, K.2    Kodama, A.3    Mammoto, A.4    Shiozaki, H.5    Monden, M.6    Takai, Y.7
  • 40
    • 0036305635 scopus 로고    scopus 로고
    • ROCK and Dia have opposing effects on adherens junctions downstream of Rho
    • Sahai E, Marshall CJ. ROCK and Dia have opposing effects on adherens junctions downstream of Rho. Nat Cell Biol. 2002;4:408-415.
    • (2002) Nat Cell Biol , vol.4 , pp. 408-415
    • Sahai, E.1    Marshall, C.J.2
  • 41
    • 0033529620 scopus 로고    scopus 로고
    • Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
    • Maekawa M, Ishizaki T, Boku S, et al. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science. 1999;285:895-898.
    • (1999) Science , vol.285 , pp. 895-898
    • Maekawa, M.1    Ishizaki, T.2    Boku, S.3
  • 42
    • 0037817325 scopus 로고    scopus 로고
    • Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer
    • Kamai T, Tsujii T, Arai K, et al. Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer. Clin Cancer Res. 2003;9:2632-2641.
    • (2003) Clin Cancer Res , vol.9 , pp. 2632-2641
    • Kamai, T.1    Tsujii, T.2    Arai, K.3
  • 43
    • 0038037737 scopus 로고    scopus 로고
    • RHOA and ROCK promote migration by limiting membrane protrusions
    • Worthylake RA, Burridge K. RHOA and ROCK promote migration by limiting membrane protrusions. J Biol Chem. 2003;278:13578-13584.
    • (2003) J Biol Chem , vol.278 , pp. 13578-13584
    • Worthylake, R.A.1    Burridge, K.2
  • 45
    • 19944432271 scopus 로고    scopus 로고
    • Anti-RHOA and anti-RHOC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo
    • Pille JY, Denoyelle C, Varet J, et al. Anti-RHOA and anti-RHOC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo. Mol Ther. 2005;11:267-274.
    • (2005) Mol Ther , vol.11 , pp. 267-274
    • Pille, J.Y.1    Denoyelle, C.2    Varet, J.3
  • 46
    • 9244237677 scopus 로고    scopus 로고
    • Functional analysis of the contribution of RHOA and RHOC GTPases to invasive breast carcinoma
    • Simpson KJ, Dugan AS, Mercurio AM. Functional analysis of the contribution of RHOA and RHOC GTPases to invasive breast carcinoma. Cancer Res. 2004;64:8694-8701.
    • (2004) Cancer Res , vol.64 , pp. 8694-8701
    • Simpson, K.J.1    Dugan, A.S.2    Mercurio, A.M.3
  • 47
    • 0036488589 scopus 로고    scopus 로고
    • Role of integrins in cell invasion and migration
    • Hood JD, Cheresh DA. Role of integrins in cell invasion and migration. Nat Rev Cancer. 2002;2:91-100. (Pubitemid 37328796)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.2 , pp. 91-100
    • Hood, J.D.1    Cheresh, D.A.2
  • 48
    • 33749000912 scopus 로고    scopus 로고
    • Type I collagen receptor (a2b1) signaling promotes the growth of human prostate cancer cells within the bone
    • Hall CL, Dai J, van Golen KL, Keller ET, Long MW. Type I collagen receptor (a2b1) signaling promotes the growth of human prostate cancer cells within the bone. Cancer Res. 2006;66:8648-8654.
    • (2006) Cancer Res , vol.66 , pp. 8648-8654
    • Hall, C.L.1    Dai, J.2    Van Golen, K.L.3    Keller, E.T.4    Long, M.W.5
  • 49
    • 48249157054 scopus 로고    scopus 로고
    • Type I collagen receptor (α2β1) signaling promotes prostate cancer invasion through RHOC GTPase
    • Hall CL, Dubyk CW, Riesenberger TA, Shein D, Keller ET, van Golen KL. Type I collagen receptor (α2β1) signaling promotes prostate cancer invasion through RHOC GTPase. Neoplasia. 2008;10:797-803.
    • (2008) Neoplasia , vol.10 , pp. 797-803
    • Hall, C.L.1    Dubyk, C.W.2    Riesenberger, T.A.3    Shein, D.4    Keller, E.T.5    Van Golen, K.L.6
  • 50
    • 0345687500 scopus 로고    scopus 로고
    • Positional control of cell fate through joint integrin-receptor protein kinase signaling
    • Giancotti FG, Tarone G. Positional control of cell fate through joint integrin-receptor protein kinase signaling. Annu Rev Cell Dev Biol. 2003;19:173.
    • (2003) Annu Rev Cell Dev Biol , vol.19 , pp. 173
    • Giancotti, F.G.1    Tarone, G.2
  • 51
    • 0042349229 scopus 로고    scopus 로고
    • ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility
    • DOI 10.1016/S1535-6108(03)00162-4
    • Vial E, Sahai E, Marshall CJ. ERK-MAPK signaling coordinately regulates activity of Rac1 and RHOA for tumor cell motility. Cancer Cell. 2003;4:67-79. (Pubitemid 36904162)
    • (2003) Cancer Cell , vol.4 , Issue.1 , pp. 67-79
    • Vial, E.1    Sahai, E.2    Marshall, C.J.3
  • 52
    • 0037474267 scopus 로고    scopus 로고
    • Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity
    • DOI 10.1074/jbc.M207943200
    • Chen JC, Zhuang S, Nguyen TH, Boss GR, Pilz RB. Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity. J Biol Chem. 2003; 278:2807-2818. (Pubitemid 36801183)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.5 , pp. 2807-2818
    • Chen, J.C.1    Zhuang, S.2    Nguyen, T.H.3    Boss, G.R.4    Pilz, R.B.5
  • 53
    • 0035865137 scopus 로고    scopus 로고
    • Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility
    • DOI 10.1093/emboj/20.4.755
    • Sahai E, Olson MF, Marshall CJ. Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility. EMBO J. 2001;20:755-766. (Pubitemid 32167640)
    • (2001) EMBO Journal , vol.20 , Issue.4 , pp. 755-766
    • Sahai, E.1    Olson, M.F.2    Marshall, C.J.3
  • 54
    • 0033620657 scopus 로고    scopus 로고
    • R-Ras signals through specific integrin a cytoplasmic domains to promote migration and invasion of breast epithelial cells
    • Keely PJ, Rusyn EV, Cox AD, Parise LV. R-Ras signals through specific integrin a cytoplasmic domains to promote migration and invasion of breast epithelial cells. J Cell Biol. 1999;145:1077.
    • (1999) J Cell Biol , vol.145 , pp. 1077
    • Keely, P.J.1    Rusyn, E.V.2    Cox, A.D.3    Parise, L.V.4
  • 55
    • 16444368158 scopus 로고    scopus 로고
    • Tumor cell invasiveness correlates with changes in integrin expression and localization
    • DOI 10.1038/sj.onc.1208423
    • Maschler S, Wirl G, Spring H, et al. Tumor cell invasiveness correlates with changes in integrin expression and localization. Oncogene. 2005;24:2032-2041. (Pubitemid 40516196)
    • (2005) Oncogene , vol.24 , Issue.12 , pp. 2032-2041
    • Maschler, S.M.1    Wirl, G.2    Spring, H.3    Bredow, D.V.4    Sordat, I.5    Beug, H.6    Reichmann, E.7
  • 56
    • 0036280716 scopus 로고    scopus 로고
    • Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer
    • DOI 10.1023/A:1015518114931
    • van Golen KL, Bao LW, Pan Q, Miller FR, Wu ZF, Merajver SD. Mitogen activated protein kinase pathway is involved in RHOC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer. Clin Exp Metastasis. 2002;19:301-311 (Pubitemid 34606755)
    • (2002) Clinical and Experimental Metastasis , vol.19 , Issue.4 , pp. 301-311
    • Van Golen, K.L.1    Wei Bao, L.2    Pan, Q.3    Miller, F.R.4    Fen Wu, Z.5    Merajver, S.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.