-
1
-
-
0022497683
-
Phenytoin: mechanisms of its anticonvulsant action
-
Yaari Y, Selzer ME, Pincus JH: Phenytoin: mechanisms of its anticonvulsant action. Ann Neurol. 1986, 20: 171-184. 10.1002/ana.410200202.
-
(1986)
Ann Neurol
, vol.20
, pp. 171-184
-
-
Yaari, Y.1
Selzer, M.E.2
Pincus, J.H.3
-
2
-
-
0018834572
-
A major pathway of mephenytoin metabolism in man. Aromatic hydroxylation to p-hydroxymephenytoin
-
Küpfer A, Brilis GM, Watson JT, Harris TM: A major pathway of mephenytoin metabolism in man. Aromatic hydroxylation to p-hydroxymephenytoin. Drug Metab Dispos. 1980, 8: 1-4.
-
(1980)
Drug Metab Dispos
, vol.8
, pp. 1-4
-
-
Küpfer, A.1
Brilis, G.M.2
Watson, J.T.3
Harris, T.M.4
-
3
-
-
0009741239
-
Reactions to nirvanol, phenytoin sodium and phenobarbital: report of a case of ectodermosis erosiva pluriorificialis following the ingestion of phenytoin sodium
-
Ellis FA: Reactions to nirvanol, phenytoin sodium and phenobarbital: report of a case of ectodermosis erosiva pluriorificialis following the ingestion of phenytoin sodium. South Med J. 1943, 36: 575-579. 10.1097/00007611-194308000-00007.
-
(1943)
South Med J
, vol.36
, pp. 575-579
-
-
Ellis, F.A.1
-
4
-
-
0021250891
-
Ethotoin in seizures of childhood and adolescence
-
Carter CA, Helms RA, Boehm R: Ethotoin in seizures of childhood and adolescence. Neurol. 1984, 34: 791-795.
-
(1984)
Neurol
, vol.34
, pp. 791-795
-
-
Carter, C.A.1
Helms, R.A.2
Boehm, R.3
-
5
-
-
0025084679
-
Sodium channel binding and anticonvulsant activities of hydantoins containing conformationally constrained 5-phenyl substituents
-
Brouillette WJ, Brown GB, DeLorey TM, Liang G: Sodium channel binding and anticonvulsant activities of hydantoins containing conformationally constrained 5-phenyl substituents. J Pharm Sci. 1990, 79: 871-874. 10.1002/jps.2600791005.
-
(1990)
J Pharm Sci
, vol.79
, pp. 871-874
-
-
Brouillette, W.J.1
Brown, G.B.2
DeLorey, T.M.3
Liang, G.4
-
6
-
-
0031052522
-
Effects of log P and phenyl ring conformation on the binding of 5-phenylhydantoins to the voltage-dependent sodium channel
-
Brown ML, Brown GB, Brouillette WJ: Effects of log P and phenyl ring conformation on the binding of 5-phenylhydantoins to the voltage-dependent sodium channel. J Med Chem. 1997, 40: 602-607. 10.1021/jm960692v.
-
(1997)
J Med Chem
, vol.40
, pp. 602-607
-
-
Brown, M.L.1
Brown, G.B.2
Brouillette, W.J.3
-
7
-
-
0018846765
-
Receptor modeling for anticonvulsant and convulsant drugs. Antiepileptic Drugs: Mechanism of Action
-
Edited by: Glasser GH, Penry JK, Woodbury DM., New York: Raven Press
-
Smythies JR: Receptor modeling for anticonvulsant and convulsant drugs. Antiepileptic Drugs: Mechanism of Action. Edited by: Glasser GH, Penry JK, Woodbury DM. 1980, New York: Raven Press, 207-222.
-
(1980)
, pp. 207-222
-
-
Smythies, J.R.1
-
8
-
-
0021332122
-
Structure-activity relationships of phenytoin-like anticonvulsant drugs
-
Poupaert JH, Vandervorst D, Guiot P, Moustafa MMM, Dumont P: Structure-activity relationships of phenytoin-like anticonvulsant drugs. J Med Chem. 1984, 27: 76-78. 10.1021/jm00367a015.
-
(1984)
J Med Chem
, vol.27
, pp. 76-78
-
-
Poupaert, J.H.1
Vandervorst, D.2
Guiot, P.3
Moustafa, M.M.M.4
Dumont, P.5
-
9
-
-
0021999826
-
Effect of structural modification of the hydantoin ring on anticonvulsant activity
-
Cortes S, Liao ZK, Watson D, Kohn H: Effect of structural modification of the hydantoin ring on anticonvulsant activity. J Med Chem. 1985, 28: 601-606. 10.1021/jm50001a012.
-
(1985)
J Med Chem
, vol.28
, pp. 601-606
-
-
Cortes, S.1
Liao, Z.K.2
Watson, D.3
Kohn, H.4
-
10
-
-
3342980671
-
5,5-Diphenyl-2-thiohydantoin
-
Roszak AW, Weaver DF: 5,5-Diphenyl-2-thiohydantoin. Acta Cryst C. 1998, 54: 1168-1170. 10.1107/S0108270197019963.
-
(1998)
Acta Cryst C
, vol.54
, pp. 1168-1170
-
-
Roszak, A.W.1
Weaver, D.F.2
-
11
-
-
0000918660
-
The influence of structure and lipophilicity of hydantoin derivatives on anticonvulsant activity
-
Scholl S, Koch A, Henning D, Kempter G, Kleinpeter E: The influence of structure and lipophilicity of hydantoin derivatives on anticonvulsant activity. Struct Chem. 1999, 10: 355-366. 10.1023/A:1022091411018.
-
(1999)
Struct Chem
, vol.10
, pp. 355-366
-
-
Scholl, S.1
Koch, A.2
Henning, D.3
Kempter, G.4
Kleinpeter, E.5
-
12
-
-
0026037184
-
Role of hydrogen bonding in general anesthesia
-
Abraham MH, Lieb WR, Franks NP: Role of hydrogen bonding in general anesthesia. J Pharm Sci. 1991, 80: 719-724. 10.1002/jps.2600800802.
-
(1991)
J Pharm Sci
, vol.80
, pp. 719-724
-
-
Abraham, M.H.1
Lieb, W.R.2
Franks, N.P.3
-
13
-
-
19444386240
-
Application of solvation equations to chemical and biochemical processes
-
Abraham MH: Application of solvation equations to chemical and biochemical processes. Pure Appl Chem. 1993, 65: 2503-2512. 10.1351/pac199365122503.
-
(1993)
Pure Appl Chem
, vol.65
, pp. 2503-2512
-
-
Abraham, M.H.1
-
14
-
-
0037107985
-
Application of hydrogen bonding calculations in property based drug design
-
Abraham MH, Ibrahim A, Zissimos AM, Zhao YH, Comer J, Reynolds DP: Application of hydrogen bonding calculations in property based drug design. Drug Discov Today. 2002, 7: 1056-1063. 10.1016/S1359-6446(02)02478-9.
-
(2002)
Drug Discov Today
, vol.7
, pp. 1056-1063
-
-
Abraham, M.H.1
Ibrahim, A.2
Zissimos, A.M.3
Zhao, Y.H.4
Comer, J.5
Reynolds, D.P.6
-
15
-
-
79953807997
-
Reversed-phase TLC and HPLC retention data in correlation studies with in silico molecular descriptors and druglikeness droperties of newly synthesized anticonvulsant succinimide derivatives
-
Perišić-Janjić N, Kaliszan R, Wiczling P, Milošević N, Ušćumlić G, Banjac N: Reversed-phase TLC and HPLC retention data in correlation studies with in silico molecular descriptors and druglikeness droperties of newly synthesized anticonvulsant succinimide derivatives. Mol Pharmaceut. 2011, 8: 555-563. 10.1021/mp100373d.
-
(2011)
Mol Pharmaceut
, vol.8
, pp. 555-563
-
-
Perišić-Janjić, N.1
Kaliszan, R.2
Wiczling, P.3
Milošević, N.4
Ušćumlić, G.5
Banjac, N.6
-
16
-
-
0041573625
-
Linear solvation energy relationships. 23. A comprehensive collection of the solvatochromic parameters, Π, α, and β, and some methods for simplifying the generalized solvatochromic equation
-
Kamlet MJ, Abboud JLM, Abraham MH, Taft RW: Linear solvation energy relationships. 23. A comprehensive collection of the solvatochromic parameters, Π, α, and β, and some methods for simplifying the generalized solvatochromic equation. J Org Chem. 1983, 48: 2877-2887. 10.1021/jo00165a018.
-
(1983)
J Org Chem
, vol.48
, pp. 2877-2887
-
-
Kamlet, M.J.1
Abboud, J.L.M.2
Abraham, M.H.3
Taft, R.W.4
-
17
-
-
34249681314
-
Solvent effects on the structure-activity relationship of pharmacological active 3-substituted-5,5-diphenylhydantoins
-
Banjac N, Ušćumlić G, Valentić N, Mijin D: Solvent effects on the structure-activity relationship of pharmacological active 3-substituted-5,5-diphenylhydantoins. J Solution Chem. 2007, 36: 869-878. 10.1007/s10953-007-9153-2.
-
(2007)
J Solution Chem
, vol.36
, pp. 869-878
-
-
Banjac, N.1
Ušćumlić, G.2
Valentić, N.3
Mijin, D.4
-
18
-
-
62549135656
-
Solvent effects on the structure-activity relationship of phenytoin-like anticonvulsant drugs
-
Trišović N, Banjac N, Valentić N, Ušćumlić G: Solvent effects on the structure-activity relationship of phenytoin-like anticonvulsant drugs. J Solution Chem. 2009, 38: 199-208. 10.1007/s10953-008-9367-y.
-
(2009)
J Solution Chem
, vol.38
, pp. 199-208
-
-
Trišović, N.1
Banjac, N.2
Valentić, N.3
Ušćumlić, G.4
-
19
-
-
0002889538
-
Syntheses of hydantoins. II. Formation of substituted hydantoins from aldehydes and ketones
-
Bucherer HT, Lieb VA: Syntheses of hydantoins. II. Formation of substituted hydantoins from aldehydes and ketones. J Prakt Chem. 1934, 141: 5-43. 10.1002/prac.19341410102.
-
(1934)
J Prakt Chem
, vol.141
, pp. 5-43
-
-
Bucherer, H.T.1
Lieb, V.A.2
-
20
-
-
3543038251
-
Active-site characteristics of CYP2C19 and CYP2C9 probed with hydantoin and barbiturate inhibitors
-
Suzuki H, Kneller MB, Rock DA, Jones JP, Trager WF, Rettie AE: Active-site characteristics of CYP2C19 and CYP2C9 probed with hydantoin and barbiturate inhibitors. Arch Biochem Biophys. 2004, 429: 1-15. 10.1016/j.abb.2004.05.015.
-
(2004)
Arch Biochem Biophys
, vol.429
, pp. 1-15
-
-
Suzuki, H.1
Kneller, M.B.2
Rock, D.A.3
Jones, J.P.4
Trager, W.F.5
Rettie, A.E.6
-
21
-
-
0037450446
-
A rapid and efficient microwave-assisted synthesis of hydantoins and thiohydantoins
-
Muccioli GG, Poupaert JH, Wouters J, Norberg B, Poppitz W, Scriba GKE, Lambert DM: A rapid and efficient microwave-assisted synthesis of hydantoins and thiohydantoins. Tetrahedron. 2003, 59: 1301-1307. 10.1016/S0040-4020(03)00033-4.
-
(2003)
Tetrahedron
, vol.59
, pp. 1301-1307
-
-
Muccioli, G.G.1
Poupaert, J.H.2
Wouters, J.3
Norberg, B.4
Poppitz, W.5
Scriba, G.K.E.6
Lambert, D.M.7
-
22
-
-
84855666555
-
Synthesis, structure and solvatochromic properties of pharmacologically active 5-substituted 5-phenylhydantoins
-
Trišović N, Valentić N, Erović M, Daković-Sekulić T, Ušćumlić G, Juranić I: Synthesis, structure and solvatochromic properties of pharmacologically active 5-substituted 5-phenylhydantoins. Monats Chem. 10.1007/s00706-011-0639-7. doi:10.1007/s00706-011-0639-7.
-
Monats Chem.
-
-
Trišović, N.1
Valentić, N.2
Erović, M.3
Daković-Sekulić, T.4
Ušćumlić, G.5
Juranić, I.6
-
23
-
-
0006469110
-
The properties of organic liquids that are relevant to their use as solvating solvents
-
Marcus Y: The properties of organic liquids that are relevant to their use as solvating solvents. Chem Soc Rev. 1993, 22: 409-416. 10.1039/cs9932200409.
-
(1993)
Chem Soc Rev
, vol.22
, pp. 409-416
-
-
Marcus, Y.1
-
24
-
-
0347862482
-
The influence of the solvent on organic reactivity. Part 5. Kinetics of the reaction of diazodiphenylmethane with benzoic acid in branched-chain alkanols and in electronegatively substituted alcohols
-
Mather D, Shorter J: The influence of the solvent on organic reactivity. Part 5. Kinetics of the reaction of diazodiphenylmethane with benzoic acid in branched-chain alkanols and in electronegatively substituted alcohols. J Chem Soc Perkin Trans II. 1983, 1179-1183.
-
(1983)
J Chem Soc Perkin Trans II.
, pp. 1179-1183
-
-
Mather, D.1
Shorter, J.2
-
25
-
-
53849098405
-
Differentiating between dipolarity and polarizability effects of solvents using the solvatochromism of barbiturate dyes
-
Bauer M, Rollberg A, Barth A, Spange S: Differentiating between dipolarity and polarizability effects of solvents using the solvatochromism of barbiturate dyes. Eur J Org Chem. 2008, 4475-4481.
-
(2008)
Eur J Org Chem.
, pp. 4475-4481
-
-
Bauer, M.1
Rollberg, A.2
Barth, A.3
Spange, S.4
-
26
-
-
37049154962
-
The absorption spectra of organic compounds containing nitrogen. I. Derivatives of hydantoin
-
Stuckey RE: The absorption spectra of organic compounds containing nitrogen. I. Derivatives of hydantoin. J Chem Soc. 1947, 169: 331-334.
-
(1947)
J Chem Soc
, vol.169
, pp. 331-334
-
-
Stuckey, R.E.1
-
27
-
-
37049075581
-
Ionization constants of 5-arylmethylenehydantoins in 80% (w/w) dimethyl sulfoxide-water at 25°
-
Tan SF, Ang KP, Fong YF, Jayachandran H: Ionization constants of 5-arylmethylenehydantoins in 80% (w/w) dimethyl sulfoxide-water at 25°. J Chem Soc Perkin Trans II. 1988, 473-476.
-
(1988)
J Chem Soc Perkin Trans II.
, pp. 473-476
-
-
Tan, S.F.1
Ang, K.P.2
Fong, Y.F.3
Jayachandran, H.4
-
28
-
-
84970948081
-
Solvents and Solvent Effects in Organic Chemistry
-
Weinheim: Wiley - VCH
-
Reinchard C: Solvents and Solvent Effects in Organic Chemistry. 2003, Weinheim: Wiley - VCH, 457.
-
(2003)
, pp. 457
-
-
Reinchard, C.1
-
29
-
-
84986550210
-
Quantitative models of steric effects
-
Unger SH, Hansch C: Quantitative models of steric effects. Prog Phys Org Chem. 1976, 12: 91-118.
-
(1976)
Prog Phys Org Chem
, vol.12
, pp. 91-118
-
-
Unger, S.H.1
Hansch, C.2
-
30
-
-
0018850819
-
Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes
-
Komiya I, Park JY, Kamani A, Ho NFH, Higuchi WI: Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes. Int J Pharm. 1980, 4: 249-262. 10.1016/0378-5173(80)90140-4.
-
(1980)
Int J Pharm
, vol.4
, pp. 249-262
-
-
Komiya, I.1
Park, J.Y.2
Kamani, A.3
Ho, N.F.H.4
Higuchi, W.I.5
-
31
-
-
0022000211
-
The absorption of β-adrenoceptor antagonists in rat in-situ small intestine the effect of lipophilicity
-
Taylor DC, Pownwall R, Burke W: The absorption of β-adrenoceptor antagonists in rat in-situ small intestine the effect of lipophilicity. J Pharm Pharmacol. 1985, 37: 280-283.
-
(1985)
J Pharm Pharmacol
, vol.37
, pp. 280-283
-
-
Taylor, D.C.1
Pownwall, R.2
Burke, W.3
-
32
-
-
0019124032
-
Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability
-
Levin VA: Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. J Med Chem. 1980, 23: 682-684. 10.1021/jm00180a022.
-
(1980)
J Med Chem
, vol.23
, pp. 682-684
-
-
Levin, V.A.1
-
33
-
-
0025311288
-
Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells
-
Artursson P: Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells. J Pharm Sci. 1990, 79: 476-482. 10.1002/jps.2600790604.
-
(1990)
J Pharm Sci
, vol.79
, pp. 476-482
-
-
Artursson, P.1
-
34
-
-
0029872476
-
Permeability of 5-fluorouracil and prodrugs in Caco-2 cell monolayers
-
Buur A, Trier L, Magnusson C, Artursson P: Permeability of 5-fluorouracil and prodrugs in Caco-2 cell monolayers. Int J Pharm. 1996, 129: 223-231. 10.1016/0378-5173(95)04331-4.
-
(1996)
Int J Pharm
, vol.129
, pp. 223-231
-
-
Buur, A.1
Trier, L.2
Magnusson, C.3
Artursson, P.4
-
35
-
-
0034992583
-
Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors
-
Zhao YH, Le J, Abraham MH, Hersey A, Eddershaw PJ, Luscombe CN, Boutina D, Beck G, Sherborne B, Cooper I, Platts JA: Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors. J Pharm Sci. 2001, 90: 749-784. 10.1002/jps.1031.
-
(2001)
J Pharm Sci
, vol.90
, pp. 749-784
-
-
Zhao, Y.H.1
Le, J.2
Abraham, M.H.3
Hersey, A.4
Eddershaw, P.J.5
Luscombe, C.N.6
Boutina, D.7
Beck, G.8
Sherborne, B.9
Cooper, I.10
Platts, J.A.11
-
36
-
-
0345306239
-
Quantitative relationship between rat intestinal absorption and Abraham descriptors
-
Zhao YH, Abraham MH, Hersey A, Luscombe CN: Quantitative relationship between rat intestinal absorption and Abraham descriptors. Eur J Med Chem. 2003, 38: 939-947. 10.1016/j.ejmech.2003.07.005.
-
(2003)
Eur J Med Chem
, vol.38
, pp. 939-947
-
-
Zhao, Y.H.1
Abraham, M.H.2
Hersey, A.3
Luscombe, C.N.4
-
37
-
-
0023546523
-
Hydrophobicity and central nervous system agents: on the principle of minimal hydrophobicity in drug design
-
Hansch C, Björkroth JP, Leo A: Hydrophobicity and central nervous system agents: on the principle of minimal hydrophobicity in drug design. J Pharm Sci. 1987, 76: 663-687. 10.1002/jps.2600760902.
-
(1987)
J Pharm Sci
, vol.76
, pp. 663-687
-
-
Hansch, C.1
Björkroth, J.P.2
Leo, A.3
-
38
-
-
0020350999
-
A quantitative structure-activity study of anticonvulsant benzyl N,N-dimethylcarbamates
-
Yamagami C, Sonoda C, Takao N, Tanaka M, Yamada J, Horisaka K, Fujita T: A quantitative structure-activity study of anticonvulsant benzyl N,N-dimethylcarbamates. Chem Pharm Bull. 1982, 30: 4175-4180.
-
(1982)
Chem Pharm Bull
, vol.30
, pp. 4175-4180
-
-
Yamagami, C.1
Sonoda, C.2
Takao, N.3
Tanaka, M.4
Yamada, J.5
Horisaka, K.6
Fujita, T.7
-
39
-
-
0030462889
-
Computation of brain-blood partitioning of organic solutes via free energy calculations
-
Lombardo F, Blake JF, Curatolo WJ: Computation of brain-blood partitioning of organic solutes via free energy calculations. J Med Chem. 1996, 39: 4750-4755. 10.1021/jm960163r.
-
(1996)
J Med Chem
, vol.39
, pp. 4750-4755
-
-
Lombardo, F.1
Blake, J.F.2
Curatolo, W.J.3
-
40
-
-
0037480602
-
ADME evaluation in drug discovery. 1. Applications of genetic algorithms to the prediction of blood-brain partitioning of a large set of drugs
-
Hou T, Xu X: ADME evaluation in drug discovery. 1. Applications of genetic algorithms to the prediction of blood-brain partitioning of a large set of drugs. J Mol Model. 2002, 8: 337-349.
-
(2002)
J Mol Model
, vol.8
, pp. 337-349
-
-
Hou, T.1
Xu, X.2
-
41
-
-
0037204545
-
Computational approaches to the prediction of the blood-brain distribution
-
Norinder U, Haeberlein M: Computational approaches to the prediction of the blood-brain distribution. Adv Drug Deliv Rev. 2002, 54: 291-313. 10.1016/S0169-409X(02)00005-4.
-
(2002)
Adv Drug Deliv Rev
, vol.54
, pp. 291-313
-
-
Norinder, U.1
Haeberlein, M.2
-
42
-
-
0020364992
-
Plasma protein binding of phenytoin in 100 epileptic patients
-
Peterson GM, McLean S, Aldous S, von Witt RJ, Mollingen KS: Plasma protein binding of phenytoin in 100 epileptic patients. Brit J Clin Pharmacol. 1982, 14: 298-300.
-
(1982)
Brit J Clin Pharmacol
, vol.14
, pp. 298-300
-
-
Peterson, G.M.1
McLean, S.2
Aldous, S.3
von Witt, R.J.4
Mollingen, K.S.5
-
43
-
-
33746868917
-
Reversible binding of some isoxazolyl penicillins with serum albumin using fluorescence spectroscopic technique
-
Seedher N, Agarwal P: Reversible binding of some isoxazolyl penicillins with serum albumin using fluorescence spectroscopic technique. Ind J Pharm Sci. 2006, 68: 327-331. 10.4103/0250-474X.26667.
-
(2006)
Ind J Pharm Sci
, vol.68
, pp. 327-331
-
-
Seedher, N.1
Agarwal, P.2
-
44
-
-
0036828938
-
Predicting plasma protein binding of drugs: a new approach
-
Kratochwil NA, Huber W, Müller F, Kansy M, Gerber PR: Predicting plasma protein binding of drugs: a new approach. Biochem Pharmacol. 2002, 64: 1355-1374. 10.1016/S0006-2952(02)01074-2.
-
(2002)
Biochem Pharmacol
, vol.64
, pp. 1355-1374
-
-
Kratochwil, N.A.1
Huber, W.2
Müller, F.3
Kansy, M.4
Gerber, P.R.5
|