Active-site characteristics of CYP2C19 and CYP2C9 probed with hydantoin and barbiturate inhibitors

Archives of Biochemistry and Biophysics

Volumn 429, Issue 1, 2004, Pages 1-15

  Suzuki, Hisashi ^a   Kneller, M Byron ^a   Rock, Dan A ^b   Jones, Jeffrey P ^b   Trager, William F ^a   Rettie, Allan E ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

CoMFA; Competitive inhibitor; CYP2C19; CYP2C9; Cytochrome P450; Stereochemistry; Synthesis

Indexed keywords

BARBITURIC ACID DERIVATIVE; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; ENZYME INHIBITOR; HYDANTOIN; HYDROCARBON SUBSTITUENT; LIGAND; N 3 BENZYLNIRVANOL; N 3 BENZYLPHENOBARBITAL; NORMEPHENYTOIN; PHENYL GROUP; PHENYTOIN; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; COMPARATIVE MOLECULAR FIELD ANALYSIS; ENZYME ACTIVE SITE; ENZYME METABOLISM; MOLECULAR INTERACTION; MOLECULAR MODEL; MOLECULAR PROBE; PREDICTION; PRIORITY JOURNAL; STEREOCHEMISTRY; SYNTHESIS; VALIDATION PROCESS;

ARYL HYDROCARBON HYDROXYLASES; BARBITURATES; BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; ENZYME ACTIVATION; HYDANTOINS; MEPHENYTOIN; MIXED FUNCTION OXYGENASES; MODELS, CHEMICAL; MODELS, MOLECULAR; PHENOBARBITAL; PHENYTOIN; PROTEIN BINDING;

EID: 3543038251     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.abb.2004.05.015     Document Type: Article

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