Synthesis and structure-activity relationships of varied ether linker analogues of the antitubercular drug (6 S)-2-nitro-6-{[4-(trifluoromethoxy) benzyl]oxy}-6,7-dihydro-5 H -imidazo[2,1- b ][1,3]oxazine (PA-824)

Journal of Medicinal Chemistry

Volumn 54, Issue 19, 2011, Pages 6563-6585

  Thompson, Andrew M ^a   Sutherland, Hamish S ^a   Palmer, Brian D ^a   Kmentova, Iveta ^a   Blaser, Adrian ^a   Franzblau, Scott G ^b   Wan, Baojie ^b   Wang, Yuehong ^b   Ma, Zhenkun ^c   Denny, William A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DIHYDRO 2 NITRO 6 (4 TRIFLUOROMETHOXYBENZYLOXY) 5H IMIDAZO[2,1 B][1,3]OXAZINE; BEDAQUILINE; DELAMANID; N (2 ADAMANTYL) N' GERANYLETHYLENEDIAMINE; PNU 100480; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; IN VITRO STUDY; LIVER MICROSOME METABOLISM; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS;

ACUTE DISEASE; ANIMALS; ANTITUBERCULAR AGENTS; CHRONIC DISEASE; ETHERS; HUMANS; MICE; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; MICROSOMES, LIVER; MYCOBACTERIUM TUBERCULOSIS; NITROIMIDAZOLES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUBERCULOSIS, PULMONARY;

EID: 80053925478     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200377r     Document Type: Article

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