An efficient route to alkyl chlorides from alcohols using the complex TCT/DMF

Organic Letters

Volumn 4, Issue 4, 2002, Pages 553-555

  De Luca, Lidia ^a   Giacomelli, Giampaolo ^a   Porcheddu, Andrea ^a  

^a UNIVERSITY OF SASSARI   (Italy)

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EID: 0000090107     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol017168p     Document Type: Article

References (24)

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22. The bromide can be recovered by accurate distillation or flash chromatography.
23. No result was obtained even with the addition of tetrabutylamonium iodide. The presence of tetrabutylammonium bromide causes the formation of the alkyl bromide in low yields.
24. 4), and the solvent evaporated to yield (S)-(1-chloromethyl-3-methylbutyl)-carbamic acid benzyl ester, which was isolated without other purifications (2,28 g, 89%).