Convenient one-pot synthesis of functionalized thieno[3,2-d]pyrimidine and thieno[2,3-d]pyrimidine derivatives

Synthesis

Volumn , Issue 20, 2011, Pages 3323-3331

  Fernández Mato, Antonio ^a   Peinador, Carlos ^a   Quintela, José María ^a  

^a UNIVERSITY OF A CORUÑA   (Spain)

Author keywords

bicyclic compounds; cyclization; domino reaction; heterocycles; Wittig reaction

Indexed keywords

BICYCLIC COMPOUNDS; DOMINO REACTIONS; FUNCTIONALIZED; GOOD YIELD; HETEROCYCLES; MULTI-GRAM QUANTITIES; ONE-POT METHOD; ONE-POT SYNTHESIS; PYRIMIDINE DERIVATIVES; SCALE-UP; WITTIG REACTION;

AROMATIC COMPOUNDS; REACTION KINETICS; SYNTHESIS (CHEMICAL);

CYCLIZATION;

2 (CYCLOHEXYLAMINO) 3 (4 NITROPHENYL)THIENO[3,2 D]PYRIMIDIN 4(3H) ONE; 2 (CYCLOHEXYLAMINO) 3 PHENYLTHIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 2 (CYCLOHEXYLAMINO) 3 PHENYLTHIENO[3,2 D]PYRIMIDIN 4(3H) ONE; 2 (ISOBUTYLAMINO) 3 PHENYLTHIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 2 (ISOBUTYLAMINO) 3 PHENYLTHIENO[3,2 D]PYRIMIDIN 4(3H) ONE; 2(DIMETHYLAMINO)THIENO[2,3 D]PYRIMIDIN 4 THIOL; 2,2' [1,4 PHENYLENEDI(SULFANEDIYL)]BIS(3 PHENYLTHIENO[2,3 D]PYRIMIDIN 4(3H) ONE); 2,2' [PROPANE 1,3 DIYLDI(IMINO)]BIS(3 PHENYLTHIENO[2,3 D]PYRIMIDIN 4(3H) ONE); 2,2' [PROPANE 1,3 DIYLDI(IMINO)]BIS(3 PHENYLTHIENO[3,2 D]PYRIMIDIN 4(3H) ONE); 3 PHENYL 2 (PHENYLSULFANYL)THIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 3 PHENYL 2 (PHENYLSULFANYL)THIENO[3,2 D]PYRIMIDIN 4(3H) ONE; 3,3' (1,3 PHENYLENE)BIS[2 (CYCLOHEXYLAMINO)THIENO[3,2 D]PYRIMIDIN 4(3H) ONE]; 3,3' (1,4 PHENYLENE)BIS[2 (CYCLOHEXYLAMINO)THIENO[3,2 D]PYRIMIDIN 4(3H) ONE]; 4 BUTYL N,N DIMETHYLTHIENO[2,3 D]PYRIMIDIN 2 AMINE; 4 CHLORO N,N DIMETHYLTHIENO[2,3 D]PYRIMIDIN 2 AMINE; 4 ETHOXY N,N DIMETHYLTHIENO[2,3 D]PYRIMIDIN 2 AMINE; N,N DIMETHYL 4 (4 METHYLPIPERAZIN 1 YL)THIENO[2,3 D]PYRIMIDIN 2 AMINE; N,N DIMETHYL 4 (4 METHYLPIPERIDIN 1 YL)THIENO[2,3 D]PYRIMIDIN 2 AMINE; N,N DIMETHYL 4 (4 TOLYL)THIENO[2,3 D]PYRIMIDIN 2 AMINE; N,N DIMETHYL 4 MORPHOLIN 1 YLTHIENO[2,3 D]PYRIMIDIN 2 AMINE; N,N DIMETHYL 4 PHENYLTHIENO[2,3 D]PYRIMIDIN 2 AMINE; N,N DIMETHYL 4 PYRROLIDIN 1 YLTHIENO[2,3 D]PYRIMIDIN 2 AMINE; N,N DIMETHYL 4(PHENYLSULFANYL)THIENO[2,3 D]PYRIMIDIN 2 AMINE; NUCLEOPHILE; PALLADIUM; PYRIMIDINE DERIVATIVE; THIENO[2,3 D]PYRIMIDINE DERIVATIVE; THIENO[3,2 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; CYCLIZATION; ELECTROSPRAY MASS SPECTROMETRY; ONE POT SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; SCALE UP; WITTIG REACTION;

EID: 80053902452     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0030-1260217     Document Type: Article

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