Antisense knockdown of inducible nitric oxide synthase inhibits induction of experimental autoimmune encephalomyelitis in SJL/J mice

Journal of Immunology

Volumn 160, Issue 6, 1998, Pages 2560-2564

  Ding, Minzhen ^a   Zhang, Ming ^a   Wong, Joyce L ^a   Rogers, Norma E ^a   Ignarro, Louis J ^a   Voskuhl, Rhonda R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; CYCLIC GMP; NITRIC OXIDE SYNTHASE;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; IMMUNOPATHOGENESIS; MOUSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RNA TRANSLATION; STEM CELL;

ANIMALS; CYCLIC GMP; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OLIGONUCLEOTIDES, ANTISENSE;

EID: 0032520788     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Ignarro, L. J., G. M. Buga, K. S. Wood, R. E. Byrns, and G. Chaudhuri. 1987. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. USA 84:9265.
2. Palmer, R. M. J., A. G. Ferrige, and S. Moncada. 1987. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327:524.
3. Garthwaite, J., S. J. Charles, and R. Chess-William. 1988. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 336:385.
4. Merrill, J. E., L. J. Ignarro, R. P. Sherman, J. Melinek, and T. E. Lane. 1993. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J. Immunol. 151:2132.
5. Lowenstein, C. J., C. S. Glatt, D. S. Bredt, and S. H. Snyder. 1995. Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proc. Natl. Acad. Sci. USA 89:6711.
6. Xie, Q. W., H. J. Cho, J. Calaycay, R. A. Mumford, K. M. Swiderek, T. D. Lee, A. Ding, T. Troso, and C. Nathan. 1992. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256:225.
7. Lamas, S., P. A. Marsden, G. K. Li, P. Tempst, and T. Michel. 1992. Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc. Natl. Acad. Sci. USA 89:6348.
8. Fredrikson, S., H. Link, and P. Eneroth. 1987. CSF neopterin as marker of disease activity in multiple sclerosis. Acta Neurol. Scand. 75:352.
9. Giovannoni, G., S. J. R. Heales, N. C. Silver, J. O. Riordan, R. F. Miller, J. M. Land, J. B. Clark, and E. T. Thompson. 1997. Raised serum nitrate and nitrite levels in patients with multiple sclerosis. J. Neurol. Sci. 145:77.
10. Bö, L., T. M. Dawson, S. Wesselingh, S. Mork, S. Choi, P. A. Kong, D. Hanley, and B. D. Trapp. 1994. Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Ann. Neurol. 36:778.
11. Boullerne, A. I., K. G. Petry, M. Meynard, and M. Geffard. 1995. Indirect evidence for nitric oxide involvement in multiple sclerosis by characterization of circulating antibodies directed against conjugated S-nitrosocysteine. J. Neuroimmunol. 60:117.
12. Beck, J., P. Rondot, L. Catinot, E. Falcoff, H. Kirchner, and J. Wietzerbin. 1988. Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: do cytokines trigger off exacerbations? Acta Neurol. Scand. 78:318.
13. Koprowski, H., Y. M. Zheng, E. Heber-Katz, N. Fraser, L. Rorke, Z. F. Fu, C. Hanlon, and B. Dietzschold. 1993. In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic disease. Proc. Natl. Acad. Sci. USA 90:3024.
14. Lin, R. F., T. S. Lin, R. G. Tilton, and A. H. Cross. 1993. Nitric oxide localized to spinal cords of mice with experimental allergic encephalomyelitis: an electron paramagnetic resonance study. J. Exp. Med. 178:643.
15. Ding, M., J. L. Wong, N. E. Rogers, L. J. Ignarro, and R. R. Voskuhl. 1997. Gender differences of inducible nitric oxide production in SJL/J mice with experimental autoimmune encephalomyelitis. J. Neuroimmunol. 77:99.
16. Cross, A. H., T. P. Misko, R. F. Lin, W. F. Mickey, J. L. Trotter, and R. G. Tilton. 1994. Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice. J. Clin. Invest. 93:2684.
17. Hooper, D. C., O. Bagasra, J. C. Marini, A. Zborek, S. T. Ohnishi, R. Kean, J. M. Champion, A. B. Sarker, L. Bobroski, J. L. Farber, T. Akaike, H. Maeda, and H. Koprowski. 1997. Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis. Proc. Natl. Acad. Sci. USA 94:2528.
18. Wong, J. M., and T. R. Billiar. 1995. Regulation and function of inducible nitric oxide synthase during sepsis and acute inflammation. In Nitric Oxide: Biochemistry, Molecular Biology, and Therapeutic Implications. L. J. Ignarro and F. Murad, eds. Academic Press, San Diego, p. 155.
19. Loke, S. L., C. A. Stein, X. H. Zhang, K. Mori, M. Nakanishi, C. Subasinghe, J. S. Cohen, and L. M. Neckers. 1989. Characterization of oligonucleotide transport into living cells. Proc. Natl. Acad. Sci. USA 86:3474.
20. Boiziau, C., N. T. Thuong, and J. J. Toulme. 1992. Mechanism of the inhibition of reverse transcription by antisense oligonucleotides. Proc. Natl. Acad. Sci. USA 89:768.
21. Dash, P., I. Lotan, M. Knapp, E. R. Kandel, and P. Goelet. 1987. Selective elimination of mRNA in vivo: complementary oligodeoxynucleotides promote RNA degradation by an RNase H-like activity. Proc. Natl. Acad. Sci. USA 84:7896.
22. Wahlestedt, C., M. Pich, G. F. Koob, F. Yee, and M. Heilig. 1993. Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science 259:528.
23. Ding, M., M. Zhang, J. L. Wong, R. R. Voskuhl, and G. W. Ellison. 1996. Antisense blockade of inducible nitric oxide synthase in glial cells derived from adult SJL mice. Neurosci. Lett. 220:89.
24. Voskuhl, R. R., H. Pitchekian-Halabi, A. MacKenzie-Graham, H. F. McFarland, and C. S. Raine. 1996. Gender differences in autoimmune demyelination in the mouse: implications for multiple sclerosis. Ann. Neurol. 39:724.
25. Ding, M., B. A. St. Pierre, J. F. Parkinson, P. Medberry, J. L. Wong, N. E. Rogers, L. J. Ignarro, and J. E. Merrill. 1997. Inducible nitric-oxide synthase and nitric oxide production in human fetal astrocytes and microglia: a kinetic analysis. J. Biol. Chem. 272:11327.
26. Simmons, M. L., and S. Murphy. 1992. Induction of nitric oxide synthase in glial cells. J. Neurochem. 59:897.
27. Bush, P. A., N. E. Gonzalez, J. M. Griscavage, and L. J. Ignarro. 1992. Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine. Biochem. Biophys. Res. Commun. 185:960.