A branched-chain organic acid linked to multiple sclerosis: First identification by NMR spectroscopy of CSF

Biochemical and Biophysical Research Communications

Volumn 354, Issue 1, 2007, Pages 160-164

  Lutz, Norbert W ^a   Viola, Angèle ^a   Malikova, Irina ^a,b   Confort Gouny, Sylviane ^a   Ranjeva, Jean Philippe ^a   Pelletier, Jean ^a,b   Cozzone, Patrick J ^a  

^a University of Aix Marseille   (France)

^b TIMONE HOSPITAL   (France)

Author keywords

3 Hydroxyisobutyrate; 1H NMR spectroscopy; Branched chain amino acids; Cerebrospinal fluid (CSF); Gluconeogenesis; Inflammatory (active) plaques; Metabolomics; Multiple sclerosis; Neurochemistry

Indexed keywords

3 HYDROXY 2 METHYLPROPIONIC ACID;

ARTICLE; CAUSAL ATTRIBUTION; CEREBROSPINAL FLUID ANALYSIS; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIAGNOSTIC IMAGING; DIAGNOSTIC PROCEDURE; DISEASE ASSOCIATION; HUMAN; METABOLITE; METABOLOMICS; MULTIPLE SCLEROSIS; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ACIDS; BIOLOGICAL MARKERS; HUMANS; HYDROXYBUTYRATES; MAGNETIC RESONANCE SPECTROSCOPY; MULTIPLE SCLEROSIS; ORGANIC CHEMICALS; PROTONS;

EID: 33846316305     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.12.169     Document Type: Article

References (16)

1. Bruck W., and Stadelmann C. The spectrum of multiple sclerosis: new lessons from pathology. Curr. Opin. Neurol. 18 (2005) 221-224
2. Nicoli F., Vion-Dury J., Confort-Gouny S., Maillet S., Gastaut J.-L., and Cozzone P.J. Cerebrospinal fluid metabolic profiles in multiple sclerosis and degenerative dementias obtained by high resolution proton magnetic resonance spectroscopy. C. R. Acad. Sci. Paris 319 (1996) 623-631
3. N.W. Lutz, A. Viola, I. Malikova, S. Confort-Gouny, J.P. Ranjeva, J. Pelletier, P.J. Cozzone, High-resolution 1H NMR Spectroscopy Reveals Differences In CSF Metabolic Profiles For MS Patients With Inflammatory vs. Non-Inflammatory Plaques, International Society of Magnetic Resonance in Medicine, 14th Scientific Meeting, Seattle, WA, USA, 2006, p. 1986.
4. Lutz N.W., Maillet S., Nicoli F., Viout P., and Cozzone P.J. Further assignment of resonances in 1H NMR spectra of cerebrospinal fluid (CSF). FEBS Lett. 425 (1998) 345-351
5. Maillet S., Vion-Dury J., Confort-Gouny S., Nicoli F., Lutz N.W., Viout P., and Cozzone P.J. Experimental protocol for clinical analysis of cerebrospinal fluid by high resolution proton magnetic resonance spectroscopy. Brain Res. Brain Res. Protoc. 3 (1998) 123-134
6. Hoffmann G.F., Jakobs C., Holmes B., Mitchell L., Becker G., Hartung H.P., and Nyhan W.L. Organic acids in cerebrospinal fluid and plasma of patients with L-2-hydroxyglutaric aciduria. J. Inherit. Metab. Dis. 18 (1995) 189-193
7. Hoffmann G., Aramaki S., Blum-Hoffmann E., Nyhan W.L., and Sweetman L. Quantitative analysis for organic acids in biological samples: batch isolation followed by gas chromatographic-mass spectrometric analysis. Clin. Chem. 35 (1989) 587-595
8. Letto J., Brosnan M.E., and Brosnan J.T. Valine metabolism. Gluconeogenesis from 3-hydroxyisobutyrate. Biochem. J. 240 (1986) 909-912
9. Lee S.H., and Davis E.J. Amino acid catabolism by perfused rat hindquarter. The metabolic fates of valine. Biochem. J. 233 (1986) 621-630
10. Chitayat D., Meagher-Villemure K., Mamer O.A., O'Gorman A., Hoar D.I., Silver K., and Scriver C.R. Brain dysgenesis and congenital intracerebral calcification associated with 3-hydroxyisobutyric aciduria. J. Pediatr. 121 (1992) 86-89
11. Sasaki M., Yamada N., Fukumizu M., and Sugai K. Basal ganglia lesions in a patient with 3-hydroxyisobutyric aciduria. Brain Dev. 28 (2006) 600-603
12. Sasaki M., Iwata H., Sugai K., Fukumizu M., Kimura M., and Yamaguchi S. A severely brain-damaged case of 3-hydroxyisobutyric aciduria. Brain Dev. 23 (2001) 243-245
13. Sasaki M., Kimura M., Sugai K., Hashimoto T., and Yamaguchi S. 3-Hydroxyisobutyric aciduria in two brothers. Pediatr. Neurol. 18 (1998) 253-255
14. Loupatty F.J., van der Steen A., Ijlst L., Ruiter J.P., Ofman R., Baumgartner M.R., Ballhausen D., Yamaguchi S., Duran M., and Wanders R.J. Clinical, biochemical, and molecular findings in three patients with 3-hydroxyisobutyric aciduria. Mol. Genet. Metab. 87 (2006) 243-248
15. Rougraff P.M., Paxton R., Kuntz M.J., Crabb D.W., and Harris R.A. Purification and characterization of 3-hydroxyisobutyrate dehydrogenase from rabbit liver. J. Biol. Chem. 263 (1988) 327-331
16. Bennett M.J., Sherwood W.G., Gibson K.M., and Burlina A.B. Secondary inhibition of multiple NAD-requiring dehydrogenases in respiratory chain complex I deficiency: possible metabolic markers for the primary defect. J. Inherit. Metab. Dis. 16 (1993) 560-562