Phosphorylation and stabilization of topoisomerase IIα protein by p38γ mitogen-activated protein kinase sensitize breast cancer cells to its poisons

Journal of Biological Chemistry

Volumn 286, Issue 41, 2011, Pages 35883-35890

  Qi, Xiaomei ^a   Hou, Songwang ^a   Lepp, Adrienne ^a   Li, Rongshan ^a   Basir, Zainab ^a   Lou, Zhenkun ^b   Chen, Guan ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER; BREAST CANCER CELLS; CANCER DRUG; CELLULAR TARGETS; GROWTH INHIBITION; MITOGEN ACTIVATED PROTEIN KINASE; PACLITAXEL; RESISTANT CELLS; THERAPEUTIC ACTIVITY; TOPOISOMERASE II;

DISEASES; PHOSPHORYLATION; PROTEINS; SIGNAL TRANSDUCTION;

CELLS;

AMSACRINE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE (ATP HYDROLYSING) ALPHA; ETOPOSIDE; MITOGEN ACTIVATED PROTEIN KINASE 12; MITOGEN ACTIVATED PROTEIN KINASE 14; PACLITAXEL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG SENSITIVITY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME STABILITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BREAST NEOPLASMS; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 12; PACLITAXEL; SIGNAL TRANSDUCTION;

EID: 80053896975     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.229260     Document Type: Article

References (49)

1. Cohen, A. A., Geva-Zatorsky, N., Eden, E., Frenkel-Morgenstern, M., Issaeva, I., Sigal, A., Milo, R., Cohen-Saidon, C., Liron, Y., Kam, Z., Cohen, L., Danon, T., Perzov, N., and Alon, U. (2008) Science 322, 1511-1516
2. Kasibhatla, S., Brunner, T., Genestier, L., Echeverri, F., Mahboubi, A., and Green, D. R. (1998) Mol. Cell 1, 543-551
3. Chen, G., Shu, J., and Stacey, D. W. (1997) Oncogene 15, 1643-1651
4. Zhang, Y. W., Otterness, D. M., Chiang, G. G., Xie, W., Liu, Y. C., Mercurio, F., and Abraham, R. T. (2005) Mol. Cell 19, 607-618
5. Pommier, Y., Sordet, O., Antony, S., Hayward, R. L., and Kohn, K. W. (2004) Oncogene 23, 2934-2949
6. Raman, M., Chen, W., and Cobb, M. H. (2007) Oncogene 26, 3100-3112
7. Avruch, J. (2007) Biochem. Biophys. Acta 1773, 1150-1160
8. Loesch, M., and Chen, G. (2008) Front. Biosci. 13, 3581-3593
9. Tang, J., Qi, X., Mercola, D., Han, J., and Chen, G. (2005) J. Biol. Chem. 280, 23910-23917
10. Qi, X., Tang, J., Loesch, M., Pohl, N., Alkan, S., and Chen, G. (2006) Cancer Res. 66, 7540-7547
11. Qi, X., Pohl, N. M., Loesch, M., Hou, S., Li, R., Qin, J. Z., Cuenda, A., and Chen, G. (2007) J. Biol. Chem. 282, 31398-31408
12. Loesch, M., Zhi, H. Y., Hou, S. W., Qi, X. M., Li, R. S., Basir, Z., Iftner, T., Cuenda, A., and Chen, G. (2010) J. Biol. Chem. 285, 15149-15158
13. Hou, S. W., Zhi, H. Y, Pohl, N., Loesch, M., Qi, X. M., Li, R. S., Basir, Z., and Chen, G. (2010) Cancer Res. 70, 2901-2910
14. Cuenda, A., Cohen, P., Buée-Scherrer, V., and Goedert, M. (1997) EMBO J. 16, 295-305
15. Wang, X., McGowan, C. H., Zhao, M., He, L., Downey, J. S., Fearns, C., Wang, Y., Huang, S., and Han, J. (2000) Mol. Cell. Biol. 20, 4543-4552
16. Gross, E. A., Callow, M. G., Waldbaum, L., Thomas, S., and Ruggieri, R. (2002) J. Biol. Chem. 277, 13873-13882
17. Chen, G., Hitomi, M., Han, J., and Stacey, D. W. (2000) J. Biol. Chem. 275, 38973-38980
18. Woessner, R. D., Chung, T. D., Hofmann, G. A., Mattern, M. R., Mirabelli, C. K., Drake, F. H., and Johnson, R. K. (1990) Cancer Res. 50, 2901-2908
19. Chen, G., Templeton, D., Suttle, D. P., and Stacey, D. W. (1999) Oncogene 18, 7149-7160
20. Juo, P., Kuo, C. J., Reynolds, S. E., Konz, R. F., Raingeaud, J., Davis, R. J., Biemann, H. P., and Blenis, J. (1997) Mol. Cell. Biol. 17, 24-35
21. Luo, K., Yuan, J., Chen, J., and Lou, Z. (2009) Nat. Cell Biol. 11, 204-210
22. Li, Z., Jiang, Y., Ulevitch, R. J., and Han, J. (1996) Biochem. Biophys. Res. Commun. 228, 334-340
23. Sabio, G., Arthur, J. S., Kuma, Y., Peggie, M., Carr, J., Murray-Tait, V., Centeno, F., Goedert, M., Morrice, N. A., and Cuenda, A. (2005) EMBO J. 24, 1134-1145
24. Chen, G., and Waxman, D. J. (1995) Biochem. Pharmacol. 49, 1691-1701
25. Stacey, D. W., Hitomi, M., and Chen, G. (2000) Mol. Cell. Biol. 20, 9127-9137
26. Mirski, S. E., Evans, C. D., Almquist, K. C., Slovak, M. L., and Cole, S. P. (1993) Cancer Res. 53, 4866-4873
27. Mensah-Osman, E. J., Al-Katib, A. M., Wu, H. Y., Osman, N. I., and Mohammad, R. M. (2002) Mol. Cancer Ther. 1, 1321-1326
28. Reinhardt, H. C., Aslanian, A. S., Lees, J. A., and Yaffe, M. B. (2007) Cancer Cell 11, 175-189
29. Chen, L., Mayer, J. A., Krisko, T. I., Speers, C. W., Wang, T., Hilsenbeck, S. G., and Brown, P. H. (2009) Cancer Res. 69, 8853-8861
30. Pillaire, M. J., Nebreda, A. R., and Darbon, J. M. (2000) Biochem. Biophys. Res. Commun. 278, 724-728
31. Conrad, P. W., Rust, R. T., Han, J., Millhorn, D. E., and Beitner-Johnson, D. (1999) J. Biol. Chem. 274, 23570-23576
32. Wells, N. J., Addison, C. M., Fry, A. M., Ganapathi, R., and Hickson, I. D. (1994) J. Biol. Chem. 269, 29746-29751
33. Escargueil, A. E., Plisov, S. Y., Filhol, O., Cochet, C., and Larsen, A. K. (2000) J. Biol. Chem. 275, 34710-34718
34. Li, H., Wang, Y., and Liu, X. (2008) J. Biol. Chem. 283, 6209-6221
35. Deming, P. B., Cistulli, C. A., Zhao, H., Graves, P. R., Piwnica-Worms, H., Paules, R. S., Downes, C. S., and Kaufmann, W. K. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 12044-12049
36. Lou, Z., Minter-Dykhouse, K., and Chen, J. (2005) Nat. Struct. Mol. Biol. 12, 589-593
37. McPherson, J. P., and Goldenberg, G. J. (1998) Cancer Res. 58, 4519-4524
38. MacGrogan, G., Rudolph, P., de Mascarel, I., Mauriac, L., Durand, M., Avril, A., Dihuydy, J. M., Robert, J., Mathoulin-Pélissier, S., Picot, V., Floquet, A., Sierankowski, G., and Coindre, J. M. (2003) Brit. J. Cancer 89, 666-671
39. Breitkreutz, A., Choi, H., Sharom, J. R., Boucher, L., Neduva, V., Larsen, B., Lin, Z. Y., Breitkreutz, B. J., Stark, C., Liu, G., Ahn, J., Dewar-Darch, D., Reguly, T., Tang, X., Almeida, R., Qin, Z. S., Pawson, T., Gingras, A. C., Nesvizhskii, A. I., and Tyers, M. (2010) Science 328, 1043-1046
40. Nitiss, J. L. (2009) Nat. Rev. Cancer 9, 327-337
41. Lippman, M. E., Allegra, J. C., Thompson, E. B., Simon, R., Barlock, A., Green, L., Huff, K. K., Do, H. M., Aitken, S. C., and Warren, R. (1978) N. Engl. J. Med. 298, 1223-1228
42. Munro, A. F., Cameron, D. A., and Bartlett, J. M. S. (2010) Oncogene 29, 5231-5240
43. Hellemans, P., van Dam, P. A., Geyskens, M., van Oosterom, A. T., Buytaert, P., and Van Marck, E. (1995) J. Clin. Pathol. 48, 147-150
44. Wang, C. Y., Mayo, M. W., and Baldwin, A. S., Jr. (1996) Science 274, 784-787
45. Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., and Greenberg, M. E. (1995) Science 270, 1326-1331
46. Arimoto, K., Fukuda, H., Imajoh-Ohmi, S., Saito, H., and Takekawa, M. (2008) Nat. Cell Biol. 10, 1324-1332
47. Stevens, C., Smith, L., and La Thangue, N. B. (2003) Nat. Cell Biol. 5, 401-409
48. Bandele, O. J., and Osheroff, N. (2008) Biochemistry 47, 11900-11908
49. Antony, S., Kohlhagen, G., Agama, K., Jayaraman, M., Cao, S., Durrani, F. A., Rustum, Y. M., Cushman, M., and Pommier, Y. (2005) Mol. Pharmacol. 67, 523-530