Ras stimulates DNA topoisomerase IIα through MEK: A link between oncogenic signaling and a therapeutic target

Oncogene

Volumn 18, Issue 50, 1999, Pages 7149-7160

  Chen, Guan ^a   Templeton, Dennis ^b   Suttle, D Parker ^c,d   Stacey, Dennis W ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cell cycle; ERK; JNK; MEKK; Ras; Topoisomerase II

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; BINDING SITE; CELL CYCLE; DRUG TARGETING; ENZYME ACTIVATION; GENE EXPRESSION; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; STIMULATION; TRANSACTIVATION; TUMOR CELL;

EID: 0033604451     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1203149     Document Type: Article

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