-
2
-
-
69549111337
-
Antibiotics for emerging pathogens
-
Fischbach M.A., Walsh C.T. Antibiotics for emerging pathogens. Science 2009, 325:1089-1093.
-
(2009)
Science
, vol.325
, pp. 1089-1093
-
-
Fischbach, M.A.1
Walsh, C.T.2
-
3
-
-
0036206726
-
Fourth generation fluoroquinolones: new weapons in the arsenal of ophthalmic antibiotics
-
Mather R., Karenchak L.M., Romanowski E.G., Kowalski R.P. Fourth generation fluoroquinolones: new weapons in the arsenal of ophthalmic antibiotics. Am J Ophthalmol 2002, 133:463-466.
-
(2002)
Am J Ophthalmol
, vol.133
, pp. 463-466
-
-
Mather, R.1
Karenchak, L.M.2
Romanowski, E.G.3
Kowalski, R.P.4
-
4
-
-
33644557421
-
When will the genomics investment pay off for antibacterial discovery?
-
Mills S.D. When will the genomics investment pay off for antibacterial discovery?. Biochem Pharmacol 2006, 71:1096-1102.
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 1096-1102
-
-
Mills, S.D.1
-
5
-
-
59449100218
-
Linezolid for the treatment of drug-resistant infections
-
Herrmann D.J., Peppard W.J., Ledeboer N.A., Theesfeld M.L., Weigelt J.A., Buechel B.J. Linezolid for the treatment of drug-resistant infections. Expert Rev Anti Infect Ther 2008, 6:825-848.
-
(2008)
Expert Rev Anti Infect Ther
, vol.6
, pp. 825-848
-
-
Herrmann, D.J.1
Peppard, W.J.2
Ledeboer, N.A.3
Theesfeld, M.L.4
Weigelt, J.A.5
Buechel, B.J.6
-
6
-
-
79953217058
-
Emergence of linezolid-resistant staphylococcus aureus after prolonged treatment of cystic fibrosis patients in cleveland, Ohio
-
Endimiani A., Blackford M., Dasenbrook E.C., Reed M.D., Bajaksouszian S., Hujer A.M., Rudin S.D., Hujer K.M., Perreten V., Rice L.B., et al. Emergence of linezolid-resistant staphylococcus aureus after prolonged treatment of cystic fibrosis patients in cleveland, Ohio. Antimicrob Agents Chemother 2011, 55:1684-1692.
-
(2011)
Antimicrob Agents Chemother
, vol.55
, pp. 1684-1692
-
-
Endimiani, A.1
Blackford, M.2
Dasenbrook, E.C.3
Reed, M.D.4
Bajaksouszian, S.5
Hujer, A.M.6
Rudin, S.D.7
Hujer, K.M.8
Perreten, V.9
Rice, L.B.10
-
7
-
-
77953265046
-
Clinical outbreak of linezolid-resistant staphylococcus aureus in an intensive care unit
-
Sanchez Garcia M., De la Torre M.A., Morales G., Pelaez B., Tolon M.J., Domingo S., Candel F.J., Andrade R., Arribi A., Garcia N., et al. Clinical outbreak of linezolid-resistant staphylococcus aureus in an intensive care unit. JAMA 2010, 303:2260-2264.
-
(2010)
JAMA
, vol.303
, pp. 2260-2264
-
-
Sanchez Garcia, M.1
De la Torre, M.A.2
Morales, G.3
Pelaez, B.4
Tolon, M.J.5
Domingo, S.6
Candel, F.J.7
Andrade, R.8
Arribi, A.9
Garcia, N.10
-
8
-
-
26944497198
-
Development of daptomycin resistance in vivo in methicillin-resistant staphylococcus aureus
-
Hayden M.K., Rezai K., Hayes R.A., Lolans K., Quinn J.P., Weinstein R.A. Development of daptomycin resistance in vivo in methicillin-resistant staphylococcus aureus. J Clin Microbiol 2005, 43:5285-5287.
-
(2005)
J Clin Microbiol
, vol.43
, pp. 5285-5287
-
-
Hayden, M.K.1
Rezai, K.2
Hayes, R.A.3
Lolans, K.4
Quinn, J.P.5
Weinstein, R.A.6
-
9
-
-
0033257746
-
The new antibiotics
-
Breithaupt H. The new antibiotics. Nat Biotechnol 1999, 17:1165-1169.
-
(1999)
Nat Biotechnol
, vol.17
, pp. 1165-1169
-
-
Breithaupt, H.1
-
10
-
-
23444440823
-
Inactivation of antibiotics and the dissemination of resistance genes
-
Davies J. Inactivation of antibiotics and the dissemination of resistance genes. Science 1994, 264:375-382.
-
(1994)
Science
, vol.264
, pp. 375-382
-
-
Davies, J.1
-
11
-
-
0345839252
-
Where will new antibiotics come from?
-
Walsh C. Where will new antibiotics come from?. Nat Rev Microbiol 2003, 1:65-70.
-
(2003)
Nat Rev Microbiol
, vol.1
, pp. 65-70
-
-
Walsh, C.1
-
12
-
-
0035993441
-
Rational identification of new antibacterial drug targets that are essential for viability using a genomics-based approach
-
Chalker A.F., Lunsford R.D. Rational identification of new antibacterial drug targets that are essential for viability using a genomics-based approach. Pharmacol Ther 2002, 95:1-20.
-
(2002)
Pharmacol Ther
, vol.95
, pp. 1-20
-
-
Chalker, A.F.1
Lunsford, R.D.2
-
13
-
-
0037100683
-
Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae
-
Thanassi J.A., Hartman-Neumann S.L., Dougherty T.J., Dougherty B.A., Pucci M.J. Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae. Nucleic Acids Res 2002, 30:3152-3162.
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 3152-3162
-
-
Thanassi, J.A.1
Hartman-Neumann, S.L.2
Dougherty, T.J.3
Dougherty, B.A.4
Pucci, M.J.5
-
14
-
-
33845903833
-
Drugs for bad bugs: confronting the challenges of antibacterial discovery
-
Payne D.J., Gwynn M.N., Holmes D.J., Pompliano D.L. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat Rev Drug Discov 2007, 6:29-40.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 29-40
-
-
Payne, D.J.1
Gwynn, M.N.2
Holmes, D.J.3
Pompliano, D.L.4
-
15
-
-
78449244856
-
Postgenomic strategies in antibacterial drug discovery
-
Brotz-Oesterhelt H., Sass P. Postgenomic strategies in antibacterial drug discovery. Future Microbiol 2010, 5:1553-1579.
-
(2010)
Future Microbiol
, vol.5
, pp. 1553-1579
-
-
Brotz-Oesterhelt, H.1
Sass, P.2
-
16
-
-
0035581737
-
Exploiting genomics to discover new antibiotics
-
McDevitt D., Rosenberg M. Exploiting genomics to discover new antibiotics. Trends Microbiol 2001, 9:611-617.
-
(2001)
Trends Microbiol
, vol.9
, pp. 611-617
-
-
McDevitt, D.1
Rosenberg, M.2
-
17
-
-
77954490085
-
Synthesis and preliminary antibacterial evaluation of 2-butyl succinate-based hydroxamate derivatives containing isoxazole rings
-
Zhang D., Jia J., Meng L., Xu W., Tang L., Wang J. Synthesis and preliminary antibacterial evaluation of 2-butyl succinate-based hydroxamate derivatives containing isoxazole rings. Arch Pharm Res 2010, 33:831-842.
-
(2010)
Arch Pharm Res
, vol.33
, pp. 831-842
-
-
Zhang, D.1
Jia, J.2
Meng, L.3
Xu, W.4
Tang, L.5
Wang, J.6
-
18
-
-
79953284147
-
Susceptibility and mode of binding of the mycobacterium tuberculosis cysteinyl transferase mycothiol ligase to trna synthetase inhibitors
-
Gutierrez-Lugo M.T., Bewley C.A. Susceptibility and mode of binding of the mycobacterium tuberculosis cysteinyl transferase mycothiol ligase to trna synthetase inhibitors. Bioorg Med Chem Lett 2011, 21:2480-2483.
-
(2011)
Bioorg Med Chem Lett
, vol.21
, pp. 2480-2483
-
-
Gutierrez-Lugo, M.T.1
Bewley, C.A.2
-
19
-
-
78649666339
-
Comparative genomics of nad(p) biosynthesis and novel antibiotic drug targets
-
Bi J., Wang H., Xie J. Comparative genomics of nad(p) biosynthesis and novel antibiotic drug targets. J Cell Physiol 2011, 226:331-340.
-
(2011)
J Cell Physiol
, vol.226
, pp. 331-340
-
-
Bi, J.1
Wang, H.2
Xie, J.3
-
21
-
-
77955673008
-
Transcriptome sequencing, microarray, and proteomic analyses reveal cellular and metabolic impact of hepatitis c virus infection in vitro
-
Woodhouse S.D., Narayan R., Latham S., Lee S., Antrobus R., Gangadharan B., Luo S., Schroth G.P., Klenerman P., Zitzmann N. Transcriptome sequencing, microarray, and proteomic analyses reveal cellular and metabolic impact of hepatitis c virus infection in vitro. Hepatology 2010, 52:443-453.
-
(2010)
Hepatology
, vol.52
, pp. 443-453
-
-
Woodhouse, S.D.1
Narayan, R.2
Latham, S.3
Lee, S.4
Antrobus, R.5
Gangadharan, B.6
Luo, S.7
Schroth, G.P.8
Klenerman, P.9
Zitzmann, N.10
-
22
-
-
73249130761
-
Simultaneous assay of every salmonella typhi gene using one million transposon mutants
-
Langridge G.C., Phan M.D., Turner D.J., Perkins T.T., Parts L., Haase J., Charles I., Maskell D.J., Peters S.E., Dougan G., et al. Simultaneous assay of every salmonella typhi gene using one million transposon mutants. Genome Res 2009, 19:2308-2316.
-
(2009)
Genome Res
, vol.19
, pp. 2308-2316
-
-
Langridge, G.C.1
Phan, M.D.2
Turner, D.J.3
Perkins, T.T.4
Parts, L.5
Haase, J.6
Charles, I.7
Maskell, D.J.8
Peters, S.E.9
Dougan, G.10
-
23
-
-
36348976352
-
Systems biology of antibiotic production by microorganisms
-
Rokem J.S., Lantz A.E., Nielsen J. Systems biology of antibiotic production by microorganisms. Nat Prod Rep 2007, 24:1262-1287.
-
(2007)
Nat Prod Rep
, vol.24
, pp. 1262-1287
-
-
Rokem, J.S.1
Lantz, A.E.2
Nielsen, J.3
-
24
-
-
77249153701
-
Genome-minimized streptomyces host for the heterologous expression of secondary metabolism
-
Komatsu M., Uchiyama T., Omura S., Cane D.E., Ikeda H. Genome-minimized streptomyces host for the heterologous expression of secondary metabolism. Proc Natl Acad Sci USA 2010, 107:2646-2651.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 2646-2651
-
-
Komatsu, M.1
Uchiyama, T.2
Omura, S.3
Cane, D.E.4
Ikeda, H.5
-
25
-
-
33746357940
-
Engineering Escherichia coli to produce nonribosomal peptide antibiotics
-
Challis G.L. Engineering Escherichia coli to produce nonribosomal peptide antibiotics. Nat Chem Biol 2006, 2:398-400.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 398-400
-
-
Challis, G.L.1
-
26
-
-
33646722147
-
Emergent properties of reduced-genome Escherichia coli
-
Posfai G., Plunkett G., Feher T., Frisch D., Keil G.M., Umenhoffer K., Kolisnychenko V., Stahl B., Sharma S.S., de Arruda M., et al. Emergent properties of reduced-genome Escherichia coli. Science 2006, 312:1044-1046.
-
(2006)
Science
, vol.312
, pp. 1044-1046
-
-
Posfai, G.1
Plunkett, G.2
Feher, T.3
Frisch, D.4
Keil, G.M.5
Umenhoffer, K.6
Kolisnychenko, V.7
Stahl, B.8
Sharma, S.S.9
de Arruda, M.10
-
27
-
-
49649095454
-
Nitrofurantoin resistance mechanism and fitness cost in Escherichia coli
-
Sandegren L., Lindqvist A., Kahlmeter G., Andersson D.I. Nitrofurantoin resistance mechanism and fitness cost in Escherichia coli. J Antimicrob Chemother 2008, 62:495-503.
-
(2008)
J Antimicrob Chemother
, vol.62
, pp. 495-503
-
-
Sandegren, L.1
Lindqvist, A.2
Kahlmeter, G.3
Andersson, D.I.4
-
28
-
-
34548213103
-
A common mechanism of cellular death induced by bactericidal antibiotics
-
Kohanski M.A., Dwyer D.J., Hayete B., Lawrence C.A., Collins J.J. A common mechanism of cellular death induced by bactericidal antibiotics. Cell 2007, 130:797-810.
-
(2007)
Cell
, vol.130
, pp. 797-810
-
-
Kohanski, M.A.1
Dwyer, D.J.2
Hayete, B.3
Lawrence, C.A.4
Collins, J.J.5
-
29
-
-
40549087912
-
Transcriptional profiling reveals that daptomycin induces the Staphylococcus aureus cell wall stress stimulon and genes responsive to membrane depolarization
-
Muthaiyan A., Silverman J.A., Jayaswal R.K., Wilkinson B.J. Transcriptional profiling reveals that daptomycin induces the Staphylococcus aureus cell wall stress stimulon and genes responsive to membrane depolarization. Antimicrob Agents Chemother 2008, 52:980-990.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 980-990
-
-
Muthaiyan, A.1
Silverman, J.A.2
Jayaswal, R.K.3
Wilkinson, B.J.4
-
30
-
-
67650751595
-
Mutational paths towards increased fluoroquinolone resistance in legionella pneumophila
-
Almahmoud I., Kay E., Schneider D., Maurin M. Mutational paths towards increased fluoroquinolone resistance in legionella pneumophila. J Antimicrob Chemother 2009, 64:284-293.
-
(2009)
J Antimicrob Chemother
, vol.64
, pp. 284-293
-
-
Almahmoud, I.1
Kay, E.2
Schneider, D.3
Maurin, M.4
-
32
-
-
70349611730
-
Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms
-
van Opijnen T., Bodi K.L., Camilli A. Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms. Nat Methods 2009, 6:767-772.
-
(2009)
Nat Methods
, vol.6
, pp. 767-772
-
-
van Opijnen, T.1
Bodi, K.L.2
Camilli, A.3
-
33
-
-
67249091712
-
Genetic dissection of an exogenously induced biofilm in laboratory and clinical isolates of E. coli
-
Amini S., Goodarzi H., Tavazoie S. Genetic dissection of an exogenously induced biofilm in laboratory and clinical isolates of E. coli. PLoS Pathog 2009, 5:e1000432.
-
(2009)
PLoS Pathog
, vol.5
-
-
Amini, S.1
Goodarzi, H.2
Tavazoie, S.3
-
34
-
-
34848889244
-
A comprehensive genetic characterization of bacterial motility
-
Girgis H.S., Liu Y., Ryu W.S., Tavazoie S. A comprehensive genetic characterization of bacterial motility. PLoS Genet 2007, 3:1644-1660.
-
(2007)
PLoS Genet
, vol.3
, pp. 1644-1660
-
-
Girgis, H.S.1
Liu, Y.2
Ryu, W.S.3
Tavazoie, S.4
-
35
-
-
66249098133
-
Genetic architecture of intrinsic antibiotic susceptibility
-
Girgis H.S., Hottes A.K., Tavazoie S. Genetic architecture of intrinsic antibiotic susceptibility. PLoS ONE 2009, 4:e5629.
-
(2009)
PLoS ONE
, vol.4
-
-
Girgis, H.S.1
Hottes, A.K.2
Tavazoie, S.3
-
36
-
-
77956328000
-
Bacterial charity work leads to population-wide resistance
-
Lee H.H., Molla M.N., Cantor C.R., Collins J.J. Bacterial charity work leads to population-wide resistance. Nature 2010, 467:82-85.
-
(2010)
Nature
, vol.467
, pp. 82-85
-
-
Lee, H.H.1
Molla, M.N.2
Cantor, C.R.3
Collins, J.J.4
-
37
-
-
58849146699
-
Toward theragnostics
-
Pene F., Courtine E., Cariou A., Mira J.P. Toward theragnostics. Crit Care Med 2009, 37(1 Suppl):S50-S58.
-
(2009)
Crit Care Med
, vol.37
, Issue.1 SUPPL
-
-
Pene, F.1
Courtine, E.2
Cariou, A.3
Mira, J.P.4
-
38
-
-
78751663199
-
Personalized treatment in the eradication therapy for Helicobacter pylori
-
Jinda S., Nakatani K., Nishioka J., Yasuda K., Soya Y., Hayashi A., Wada H., Nobori T. Personalized treatment in the eradication therapy for Helicobacter pylori. Int J Mol Med 2011, 27:255-261.
-
(2011)
Int J Mol Med
, vol.27
, pp. 255-261
-
-
Jinda, S.1
Nakatani, K.2
Nishioka, J.3
Yasuda, K.4
Soya, Y.5
Hayashi, A.6
Wada, H.7
Nobori, T.8
-
39
-
-
70350513571
-
Enzymic colorimetry-based DNA chip: a rapid and accurate assay for detecting mutations for clarithromycin resistance in the 23s rrna gene of Helicobacter pylori
-
Xuan S.H., Zhou Y.G., Shao B., Cui Y.L., Li J., Yin H.B., Song X.P., Cong H., Jing F.X., Jin Q.H., et al. Enzymic colorimetry-based DNA chip: a rapid and accurate assay for detecting mutations for clarithromycin resistance in the 23s rrna gene of Helicobacter pylori. J Med Microbiol 2009, 58(Pt 11):1443-1448.
-
(2009)
J Med Microbiol
, vol.58
, Issue.PART 11
, pp. 1443-1448
-
-
Xuan, S.H.1
Zhou, Y.G.2
Shao, B.3
Cui, Y.L.4
Li, J.5
Yin, H.B.6
Song, X.P.7
Cong, H.8
Jing, F.X.9
Jin, Q.H.10
-
40
-
-
0034644010
-
A triclosan-resistant bacterial enzyme
-
Heath R.J., Rock C.O. A triclosan-resistant bacterial enzyme. Nature 2000, 406:145-146.
-
(2000)
Nature
, vol.406
, pp. 145-146
-
-
Heath, R.J.1
Rock, C.O.2
-
41
-
-
75749138079
-
Triclosan resistance of Pseudomonas aeruginosa pao1 is due to fabv, a triclosan-resistant enoyl-acyl carrier protein reductase
-
Zhu L., Lin J., Ma J., Cronan J.E., Wang H. Triclosan resistance of Pseudomonas aeruginosa pao1 is due to fabv, a triclosan-resistant enoyl-acyl carrier protein reductase. Antimicrob Agents Chemother 2010, 54:689-698.
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 689-698
-
-
Zhu, L.1
Lin, J.2
Ma, J.3
Cronan, J.E.4
Wang, H.5
-
42
-
-
79958826431
-
Whole-genome comparison of two Acinetobacter baumannii isolates from a single patient, where resistance developed during tigecycline therapy
-
Hornsey M., Loman N., Wareham D.W., Ellington M.J., Pallen M.J., Turton J.F., Underwood A., Gaulton T., Thomas C.P., Doumith M., et al. Whole-genome comparison of two Acinetobacter baumannii isolates from a single patient, where resistance developed during tigecycline therapy. J Antimicrob Chemother 2011, 66:1499-1503.
-
(2011)
J Antimicrob Chemother
, vol.66
, pp. 1499-1503
-
-
Hornsey, M.1
Loman, N.2
Wareham, D.W.3
Ellington, M.J.4
Pallen, M.J.5
Turton, J.F.6
Underwood, A.7
Gaulton, T.8
Thomas, C.P.9
Doumith, M.10
-
43
-
-
78649565669
-
Comparative genomics of the bacterial genus listeria: genome evolution is characterized by limited gene acquisition and limited gene loss
-
den Bakker H.C., Cummings C.A., Ferreira V., Vatta P., Orsi R.H., Degoricija L., Barker M., Petrauskene O., Furtado M.R., Wiedmann M. Comparative genomics of the bacterial genus listeria: genome evolution is characterized by limited gene acquisition and limited gene loss. BMC Genomics 2010, 11:688.
-
(2010)
BMC Genomics
, vol.11
, pp. 688
-
-
den Bakker, H.C.1
Cummings, C.A.2
Ferreira, V.3
Vatta, P.4
Orsi, R.H.5
Degoricija, L.6
Barker, M.7
Petrauskene, O.8
Furtado, M.R.9
Wiedmann, M.10
-
44
-
-
79960069353
-
Metagenomics
-
Gilbert J.A., Laverock B., Temperton B., Thomas S., Muhling M., Hughes M. Metagenomics. Methods Mol Biol 2011, 733:173-183.
-
(2011)
Methods Mol Biol
, vol.733
, pp. 173-183
-
-
Gilbert, J.A.1
Laverock, B.2
Temperton, B.3
Thomas, S.4
Muhling, M.5
Hughes, M.6
-
45
-
-
56849106496
-
The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16s rrna sequencing
-
Dethlefsen L., Huse S., Sogin M.L., Relman D.A. The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16s rrna sequencing. PLoS Biol 2008, 6:e280.
-
(2008)
PLoS Biol
, vol.6
-
-
Dethlefsen, L.1
Huse, S.2
Sogin, M.L.3
Relman, D.A.4
-
46
-
-
78649895980
-
Vancomycin-resistant enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans
-
Ubeda C., Taur Y., Jenq R.R., Equinda M.J., Son T., Samstein M., Viale A., Socci N.D., van den Brink M.R., Kamboj M., Pamer E.G. Vancomycin-resistant enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans. J Clin Invest 2010, 120:4332-4341.
-
(2010)
J Clin Invest
, vol.120
, pp. 4332-4341
-
-
Ubeda, C.1
Taur, Y.2
Jenq, R.R.3
Equinda, M.J.4
Son, T.5
Samstein, M.6
Viale, A.7
Socci, N.D.8
van den Brink, M.R.9
Kamboj, M.10
Pamer, E.G.11
-
47
-
-
77955637274
-
Methicillin resistance transfer from staphylocccus epidermidis to methicillin-susceptible Staphylococcus aureus in a patient during antibiotic therapy
-
Bloemendaal A.L., Brouwer E.C., Fluit A.C. Methicillin resistance transfer from staphylocccus epidermidis to methicillin-susceptible Staphylococcus aureus in a patient during antibiotic therapy. PLoS ONE 2010, 5:e11841.
-
(2010)
PLoS ONE
, vol.5
-
-
Bloemendaal, A.L.1
Brouwer, E.C.2
Fluit, A.C.3
-
48
-
-
56249128990
-
Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary
-
Banik J.J., Brady S.F. Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary. Proc Natl Acad Sci USA 2008, 105:17273-17277.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 17273-17277
-
-
Banik, J.J.1
Brady, S.F.2
|