Ganoderma lucidum (Reishi) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer

Nutrition and Cancer

Volumn 63, Issue 7, 2011, Pages 1085-1094

  Martínez Montemayor, Michelle M ^a   Acevedo, Raysa Rosario ^a   Otero Franqui, Elisa ^b   Cubano, Luis A ^a   Dharmawardhane, Suranganie F ^b  

^a Universidad Central del Caribe School of Medicine   (Puerto Rico)

^b UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

Author keywords

[No Author keywords available]

Indexed keywords

GANODERMA LUCIDUM EXTRACT;

APOPTOSIS; ARTICLE; BREAST EPITHELIUM; CANCER CELL; CANCER INHIBITION; CELL INVASION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INFLAMMATORY BREAST CANCER; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BLOTTING, WESTERN; CADHERINS; CATENINS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; EUKARYOTIC INITIATION FACTOR-4G; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INFLAMMATORY BREAST NEOPLASMS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROTO-ONCOGENE PROTEINS C-MYC; REAL-TIME POLYMERASE CHAIN REACTION; REISHI;

BASIDIOMYCOTA; GANODERMA LUCIDUM;

EID: 80053636271     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2011.601845     Document Type: Article

References (50)

1. Jemal A, Siegel R, Xu J, and Ward E: Cancer statistics, 2010. CA Cancer J Clin 60, 277-300, 2010.
2. Shenkier T, Weir L, Levine M, Olivotto I, Whelan T, et al.: Clinical practice guidelines for the care and treatment of breast cancer: 15. Treatment for women with stage III or locally advanced breast cancer. CMAJ 16, 983-994, 2004. (Pubitemid 38392196)
3. Yun TK: Update from Asia. Asian studies on cancer chemoprevention. Ann NY Acad Sci 889, 157-192, 1999.
4. Lin ZB: Cellular and molecular mechanisms of immunomodulation by Ganoderma lucidum. J Pharmacol Sci 99, 144-153, 2005.
5. Zhu XL, Chen AF, and Lin ZB: Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice. J Ethnopharmacol 111, 219-226, 2007.
6. Jiang J, Grieb B, Thyagarajan A, and Sliva D: Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling. Int J Mol Med 21, 577-584, 2008.
7. Lee S, Park S, Oh JW, and Yang C: Natural inhibitors for protein prenyl-transferase. Planta Med 64, 303-308, 1998.
8. Thyagarajan A, Jedinak A, Nguyen H, Terry C, Baldridge LA, et al.: Triter-penes from Ganoderma Lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK). Nutr Cancer 62, 630-640, 2010.
9. Lin SB, Li CH, Lee SS, and Kan LS: Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest. Life Sci 72, 2381-2390, 2003.
10. Sliva D, Labarrere C, Slivova V, Sedlak M, Lloyd FP, Jr., et al.: Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells. Biochem Biophys Res Commun 298, 603-612, 2002. (Pubitemid 35333701)
11. Hoffmeyer MR, Wall KM, and Dharmawardhane SF: In vitro analysis of the invasive phenotype of SUM 149, an inflammatory breast cancer cell line. Cancer Cell Int 5, 11, 2005.
12. Lo AC, Georgopoulos A, Kleer CG, Banerjee M, Omar S, et al.: Analysis of RhoC expression and lymphovascular emboli in inflammatory vs. noninflammatory breast cancers in Egyptian patients. Breast 18, 55-59, 2009.
13. Tomlinson JS, Alpaugh ML, and Barsky SH: An intact overexpressed E-cadherin/alpha, beta-catenin axis characterizes the lymphovascular emboli of inflammatory breast carcinoma. Cancer Res 61, 5231-5241, 2001. (Pubitemid 32681558)
14. Yamauchi H and Ueno NT: Targeted therapy in inflammatory breast cancer. Cancer 116, 2758-2759, 2010.
15. Sliva D: Cellular and physiological effects of Ganoderma lucidum (Reishi). Mini Rev Med Chem 4, 873-879, 2004. (Pubitemid 39200074)
16. Silvera D, Arju R, Darvishian F, Levine PH, Zolfaghari L, et al.: Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer. Nat Cell Biol 11, 903-908, 2009.
17. Yuen JW, Gohel MD, and Au DW: Telomerase-associated apoptotic events by mushroom ganoderma lucidum on premalignant human urothelial cells. Nutr Cancer 60, 109-119, 2008. (Pubitemid 351186221)
18. Ethier SP, Kokeny KE, Ridings JW, and Dilts CA: erbB family receptor expression and growth regulation in a newly isolated human breast cancer cell line. Cancer Res 56, 899-907, 1996. (Pubitemid 26055484)
19. Welch DR, Harms JF, Mastro AM, Gay CV, and Donahue HJ: Breast cancer metastasis to bone: evolving models and research challenges. J Musculoskelet Neuronal Interact 3, 30-38, 2003. (Pubitemid 36443180)
20. Schlachterman A, Valle F, Wall KM, Azios NG, Castillo L, et al.: Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model. Transl Oncol 1, 19-27, 2008.
21. Oude Weernink PA, Verheul E, Kerkhof E, van Veelen CW, and Rijksen G: Inhibitors of protein tyrosine phosphorylation reduce the proliferation of two human glioma cell lines. Neurosurgery 38, 108-113, 1996.
22. Castillo-Pichardo L, Martinez-Montemayor MM, Martinez JE, Wall KM, Cubano LA, et al.: Inhibition of mammary tumor growth and metastases to bone and liver by dietary grape polyphenols. Clin Exp Metastasis 26, 505-516, 2009.
23. Azios NG, Krishnamoorthy L, Harris M, Cubano LA, Cammer M, et al.: Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells. Neoplasia 9, 147-158, 2007.
24. Hibbs MS, Hasty KA, Seyer JM, Kang AH, and Mainardi CL: Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase. J Biol Chem 260, 2493-2500, 1985. (Pubitemid 15104858)
25. Martinez-Montemayor MM, Otero-Franqui E, Martinez J, De La Mota-Peynado A, Cubano LA, et al.: Individual and combined soy isoflavones exert differential effects on metastatic cancer progression. Clin Exp Metastasis 27, 465-480, 2010.
26. Martinez-Montemayor MM, Hill GM, Raney NE, Rilington VD, Tempelman RJ, et al.: Gene expression profiling in hepatic tissue of newly weaned pigs fed pharmacological zinc and phytase supplemented diets. BMC Genomics 9, 421, 2008.
27. Hu H, Ahn NS, Yang X, Lee YS, and Kang KS: Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell. Int J Cancer 102, 250-253, 2002. (Pubitemid 35222292)
28. Jiang J, Slivova V, and Sliva D: Ganoderma lucidum inhibits proliferation of human breast cancer cells by downregulation of estrogen receptor and NF-kappaB signaling. Int J Oncol 29, 695-703, 2006.
29. Tang W, Liu JW, Zhao WM, Wei DZ, and Zhong JJ: Ganoderic acidTfrom Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells. Life Sci 80, 205-211, 2006. (Pubitemid 44853986)
30. Muller CI, Kumagai T, O'Kelly J, Seeram NP, Heber D, et al.: Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells. Leuk Res 30, 841-848, 2006. (Pubitemid 43816702)
31. Kleer CG, van Golen KL, and Merajver SD: Molecular biology of breast cancer metastasis: inflammatory breast cancer: clinical syndrome and molecular determinants. Breast Cancer Res 2, 423-429, 2000. (Pubitemid 32223639)
32. Jiang J, Slivova V, Valachovicova T, Harvey K, and Sliva D: Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. Int J Oncol 24, 1093-1099, 2004.
33. Van Laere S, Van der Auwera I, Van den Eynden GG, Fox SB, Bianchi F, et al.: Distinct molecular signature of inflammatory breast cancer by cDNA microarray analysis. Breast Cancer Res Treat 93, 237-246, 2005. (Pubitemid 41441293)
34. Huang W, Zhang Y, Varambally S, Chinnaiyan AM, Banerjee M, et al.: Inhibition of CCN6 (Wnt-1-induced signaling protein 3) downregulates E-cadherin in the breast epithelium through induction of snail and ZEB1. Am J Pathol 172, 893-904, 2008. (Pubitemid 351519987)
35. Jiang J, Slivova V, Harvey K, Valachovicova T, and Sliva D. Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-kappaB signaling. Nutr Cancer 49, 209-216, 2004. (Pubitemid 39487881)
36. Kim KC, Kim JS, Son JK, and Kim IG: Enhanced induction of mito-chondrial damage and apoptosis in human leukemia HL-60 cells by the Ganoderma lucidum and Duchesnea chrysantha extracts. Cancer Lett 246, 210-217, 2007. (Pubitemid 46001503)
37. Jang KJ, Han MH, Lee BH, Kim BW, Kim CH, etal.: Induction of apoptosis by ethanol extracts of Ganoderma lucidum in human gastric carcinoma cells. J Acupunct Meridian Stud 3, 24-31, 2010.
38. Yamauchi H, Cristofanilli M, Nakamura S, Hortobagyi GN, and Ueno NT: Molecular targets for treatment of inflammatory breast cancer. Nat Rev Clin Oncol 6, 387-394, 2009.
39. Price JT, Bonovich MT, and Kohn EC: The biochemistry of cancer dissemination. Crit Rev Biochem Mol Biol 32, 175-253, 1997. (Pubitemid 27305153)
40. Price JT and Thompson EW: Mechanisms of tumour invasion and metastasis: emerging targets for therapy. Expert Opin Ther Targets 6, 217-233, 2002. (Pubitemid 34477462)
41. Shirakawa K, Kobayashi H, Heike Y, Kawamoto S, Brechbiel MW, et al.: Hemodynamics in vasculogenic mimicry and angiogenesis of inflammatory breast cancer xenograft. Cancer Res 62, 560-566, 2002. (Pubitemid 34106432)
42. Liotta LA, Saidel MG, and Kleinerman J: The significanceofhematogenous tumor cell clumps in the metastatic process. Cancer Res 36, 889-894, 1976.
43. Alpaugh ML, Tomlinson JS, Shao ZM, and Barsky SH: A novel human xenograft model ofinflammatory breast cancer. Cancer Res 59, 5079-5084, 1999. (Pubitemid 29503962)
44. Van den Eynden GG, Van der Auwera I, Van Laere S, Colpaert CG, van Dam P, et al.: Validation of a tissue microarray to study differential protein expression in inflammatory and noninflammatory breast cancer. Breast Cancer Res Treat 85, 13-22, 2004. (Pubitemid 38437979)
45. Alpaugh M, Tomlinson J, Kasraeian S, and Barsky S: Cooperative role of E-cadherin and sialyl-Lewis X/A-deficient MUC1 in the passive dissemination of tumor emboli in inflammatory breast carcinoma. Oncogene 21, 3631-3643, 2002. (Pubitemid 34587695)
46. Nollet F, Berx G, and van Roy F: The role of the E-cadherin/catenin adhesion complex in the development and progression of cancer. Mol Cell Biol Res Commun 2, 77-85, 1999. (Pubitemid 129532310)
47. Thyagarajan A, Jiang J, Hopf A, Adamec J, and Sliva D: Inhibition of ox-idative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion. Int J Mol Med 18, 657-664, 2006.
48. Bjorklund M and Koivunen E: Gelatinase-mediated migration and invasion of cancer cells. Biochim Biophys Acta 1755, 37-69, 2005. (Pubitemid 40720240)
49. Dong HM, Liu G, Hou YF, Wu J, Lu JS, et al.: Dominant-negative E-cadherin inhibits the invasiveness of inflammatory breast cancer cells in vitro. J Cancer Res Clin Oncol 133, 83-92, 2007. (Pubitemid 44950240)
50. Weng CJ, Chau CF, Hsieh YS, Yang SF, and Yen GC: Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-kappaB and AP-1. Carcinogenesis 29, 147-156, 2008.