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Volumn 3, Issue 1, 2003, Pages 30-38

Breast cancer metastasis to bone: Evolving models and research challenges

Author keywords

4T1; Adhesion; Chemokine; Green fluorescent protein; MDA MB 231; MDA MB 435; Organotropism; Osteoblast; Osteoclast; Osteolysis; Osteonectin; Osteopontin; Osteoprotegrin; PTHrP; RANK; RANK L

Indexed keywords

CHEMOKINE; GELATINASE A; OSTEONECTIN; OSTEOPONTIN; OSTEOPROTEGERIN; PARATHYROID HORMONE RELATED PROTEIN; SIALOPROTEIN;

EID: 0037359909     PISSN: 11087161     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (16)

References (96)
  • 3
    • 0030749321 scopus 로고    scopus 로고
    • Skeletal complications of malignancy
    • Coleman RE. Skeletal complications of malignancy. Cancer 1997; 80:1588-1594.
    • (1997) Cancer , vol.80 , pp. 1588-1594
    • Coleman, R.E.1
  • 4
    • 0032512898 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of breast and prostate cancer metastasis to bone
    • Yoneda T. Cellular and molecular mechanisms of breast and prostate cancer metastasis to bone. Eur J Cancer 1998; 34:240-245.
    • (1998) Eur. J. Cancer , vol.34 , pp. 240-245
    • Yoneda, T.1
  • 6
    • 0004101430 scopus 로고    scopus 로고
    • Cancer and the skeleton
    • London, Martin Dunitz, London
    • Rubens RD, Mundy GR. Cancer and the skeleton. London, Martin Dunitz, London; 2000.
    • (2000)
    • Rubens, R.D.1    Mundy, G.R.2
  • 7
    • 0030879065 scopus 로고    scopus 로고
    • Mechanisms of bone metastasis
    • Mundy GR. Mechanisms of bone metastasis. Cancer 1997; 80:1546-1556.
    • (1997) Cancer , vol.80 , pp. 1546-1556
    • Mundy, G.R.1
  • 8
    • 50549121134 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget S. The distribution of secondary growths in cancer of the breast. Lancet 1889; 1:571-573.
    • (1889) Lancet , vol.1 , pp. 571-573
    • Paget, S.1
  • 11
    • 0035321087 scopus 로고    scopus 로고
    • Leukocyte recruitment in the microcirculation: The rolling paradigm revisited
    • Kubes P, Kerfoot SM. Leukocyte recruitment in the microcirculation: the rolling paradigm revisited. News Physiol Sci 2001; 16:76-80.
    • (2001) News Physiol. Sci. , vol.16 , pp. 76-80
    • Kubes, P.1    Kerfoot, S.M.2
  • 12
    • 0033040308 scopus 로고    scopus 로고
    • Adhesion and homing of blood-borne cells in bone marrow microvessels
    • Mazo IB, Von Andrian UH. Adhesion and homing of blood-borne cells in bone marrow microvessels. J Leukoc Biol 1999; 66:25-32.
    • (1999) J. Leukoc. Biol. , vol.66 , pp. 25-32
    • Mazo, I.B.1    Von Andrian, U.H.2
  • 13
  • 14
    • 0020111507 scopus 로고
    • Quantitation of regional chondro-osseous circulation in canine tibia and femur
    • Schnitzer JE, McKinstry P, Light TR, Ogden JA. Quantitation of regional chondro-osseous circulation in canine tibia and femur. Am J Physiol 1982; 242:H365-H375.
    • (1982) Am. J. Physiol. , vol.242
    • Schnitzer, J.E.1    McKinstry, P.2    Light, T.R.3    Ogden, J.A.4
  • 15
    • 0029932458 scopus 로고    scopus 로고
    • Organ targeting in vivo using phage display peptide libraries
    • Pasqualini R, Ruoslahti E. Organ targeting in vivo using phage display peptide libraries. Nature 1996; 380:364-366.
    • (1996) Nature , vol.380 , pp. 364-366
    • Pasqualini, R.1    Ruoslahti, E.2
  • 16
    • 0034082218 scopus 로고    scopus 로고
    • An address system in the vasculature of normal tissues and tumors
    • Ruoslahti E, Rajotte D. An address system in the vasculature of normal tissues and tumors. Ann Rev Immunol 2000; 18:813-827.
    • (2000) Ann. Rev. Immunol. , vol.18 , pp. 813-827
    • Ruoslahti, E.1    Rajotte, D.2
  • 17
    • 0031964011 scopus 로고    scopus 로고
    • IGF system components as prognostic markers in breast cancer
    • Lee AV, Hilsenbeck SG, Yee D. IGF system components as prognostic markers in breast cancer. Breast Cancer Res Treat 1998; 47:295-302.
    • (1998) Breast Cancer Res. Treat , vol.47 , pp. 295-302
    • Lee, A.V.1    Hilsenbeck, S.G.2    Yee, D.3
  • 18
    • 0032479875 scopus 로고    scopus 로고
    • Hematopoietic progenitor cell rolling in bone marrow microvessels: Parallel contributions by endothelial selectins and vascular cell adhesion molecule 1
    • Mazo IB, Gutierrez-Ramos JC, Frenette PS, Hynes RO, Wagner DD, Von Andrian UH. Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. J Exp Med 1998; 188:465-474.
    • (1998) J. Exp. Med. , vol.188 , pp. 465-474
    • Mazo, I.B.1    Gutierrez-Ramos, J.C.2    Frenette, P.S.3    Hynes, R.O.4    Wagner, D.D.5    Von Andrian, U.H.6
  • 19
    • 0027982876 scopus 로고
    • Traffic signals for lymphocyte recirculation and leukocyte emigration: A multistep paradigm
    • Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: a multistep paradigm. Cell 1994; 76:301-314.
    • (1994) Cell , vol.76 , pp. 301-314
    • Springer, T.A.1
  • 21
    • 0022646354 scopus 로고
    • Promotion of pulmonary metastases in mice by bleomycin-induced endothelial injury
    • Orr FW, Adamson IYR, Young L. Promotion of pulmonary metastases in mice by bleomycin-induced endothelial injury. Cancer Res 1986; 46:891-897.
    • (1986) Cancer Res. , vol.46 , pp. 891-897
    • Orr, F.W.1    Adamson, I.Y.R.2    Young, L.3
  • 22
    • 0141632465 scopus 로고
    • The microinjury hypothesis and metastasis
    • Warren BA. The microinjury hypothesis and metastasis. Dev Oncol 1984; 22:56-61.
    • (1984) Dev. Oncol. , vol.22 , pp. 56-61
    • Warren, B.A.1
  • 23
    • 0033895701 scopus 로고    scopus 로고
    • Intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and regulated on activation normal T cell expressed and secreted are expressed by human breast carcinoma cells and support eosinophil adhesion and activation
    • Ali S, Kaur J, Patel KD. Intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and regulated on activation normal T cell expressed and secreted are expressed by human breast carcinoma cells and support eosinophil adhesion and activation. Am J Pathol 2000; 157:313-321.
    • (2000) Am. J. Pathol. , vol.157 , pp. 313-321
    • Ali, S.1    Kaur, J.2    Patel, K.D.3
  • 25
    • 0029664850 scopus 로고    scopus 로고
    • The breast mucin MUC1 as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer
    • Regimbald LH, Pilarski LM, Longenecker BM, Reddish MA, Zimmermann G, Hugh JC. The breast mucin MUC1 as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer. Cancer Res 1996; 56:4244-4249.
    • (1996) Cancer Res. , vol.56 , pp. 4244-4249
    • Regimbald, L.H.1    Pilarski, L.M.2    Longenecker, B.M.3    Reddish, M.A.4    Zimmermann, G.5    Hugh, J.C.6
  • 26
    • 0018579301 scopus 로고
    • Interactions of tumor cells with vascular endothelial cell monolayers: A model for metastatic invasion
    • Kramer RH, Nicolson GL. Interactions of tumor cells with vascular endothelial cell monolayers: a model for metastatic invasion. Proc Natl Acad Sci USA 1979; 76:5704-5708.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 5704-5708
    • Kramer, R.H.1    Nicolson, G.L.2
  • 27
    • 0028203274 scopus 로고
    • SPARC (secreted protein acidic and rich in cysteine) regulates endothelial cell shape and barrier function
    • Goldblum SE, Ding X, Funk SE, Sage EH. SPARC (secreted protein acidic and rich in cysteine) regulates endothelial cell shape and barrier function. Proc Natl Acad Sci USA 1994; 91:3448-3452.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 3448-3452
    • Goldblum, S.E.1    Ding, X.2    Funk, S.E.3    Sage, E.H.4
  • 29
    • 0033199111 scopus 로고    scopus 로고
    • Osteonectin promotes prostate cancer cell migration and invasion: A possible mechanism for metastasis to bone
    • Jacob K, Webber M, Benayahu D, Kleinman HK. Osteonectin promotes prostate cancer cell migration and invasion: a possible mechanism for metastasis to bone. Cancer Res 1999; 59:4453-4457.
    • (1999) Cancer Res. , vol.59 , pp. 4453-4457
    • Jacob, K.1    Webber, M.2    Benayahu, D.3    Kleinman, H.K.4
  • 30
    • 0030575895 scopus 로고    scopus 로고
    • Cell migration promoted by a potent GRGDS-containing thrombin-cleavage fragment of osteopontin
    • 1314
    • Senger DR, Perruzzi CA. Cell migration promoted by a potent GRGDS-containing thrombin-cleavage fragment of osteopontin. Biochim Biophys Acta 1996; 1314:13-24.
    • (1996) Biochim. Biophys. Acta , pp. 13-24
    • Senger, D.R.1    Perruzzi, C.A.2
  • 31
    • 0031856539 scopus 로고    scopus 로고
    • Bone sialoprotein supports breast cancer cell adhesion proliferation and migration through differential usage of the alpha(v)beta3 and alpha(v)beta5 integrins
    • Sung V, Stubbs JT III, Fisher L, Aaron AD, Thompson EW. Bone sialoprotein supports breast cancer cell adhesion proliferation and migration through differential usage of the alpha(v)beta3 and alpha(v)beta5 integrins. J Cell Physiol 1998; 176:482-494.
    • (1998) J. Cell Physiol. , vol.176 , pp. 482-494
    • Sung, V.1    Stubbs J.T. III2    Fisher, L.3    Aaron, A.D.4    Thompson, E.W.5
  • 32
    • 0018350553 scopus 로고
    • Chemotactic responses of tumor cells to products of resorbing bone
    • Orr W, Varani J, Gondex MK, Ward PA, Mundy GR. Chemotactic responses of tumor cells to products of resorbing bone. Science 1979; 203:176-179.
    • (1979) Science , vol.203 , pp. 176-179
    • Orr, W.1    Varani, J.2    Gondex, M.K.3    Ward, P.A.4    Mundy, G.R.5
  • 33
    • 4244194776 scopus 로고    scopus 로고
    • Scanning electron microscopy reveals directional responses of breast cancer cells to osteonectin
    • Gay CV, Mastro AM, Welch DR. Scanning electron microscopy reveals directional responses of breast cancer cells to osteonectin. J Bone Miner Res 2001; 16:S333.
    • (2001) J. Bone Miner. Res. , vol.16
    • Gay, C.V.1    Mastro, A.M.2    Welch, D.R.3
  • 34
    • 0032401846 scopus 로고    scopus 로고
    • SPARC/osteonectin induces matrix metalloproteinase 2 activation in human breast cancer cell lines
    • Gilles C, Bassuk JA, Pulyaeva H, Sage EH, Foidart JM, Thompson EW. SPARC/osteonectin induces matrix metalloproteinase 2 activation in human breast cancer cell lines. Cancer Res 1998; 58:5529-5536.
    • (1998) Cancer Res. , vol.58 , pp. 5529-5536
    • Gilles, C.1    Bassuk, J.A.2    Pulyaeva, H.3    Sage, E.H.4    Foidart, J.M.5    Thompson, E.W.6
  • 36
    • 0027131418 scopus 로고
    • Osteopontin: A protein with diverse functions
    • Denhardt DT, Guo X. Osteopontin: a protein with diverse functions. FASEB J 1993; 7:1475-1482.
    • (1993) FASEB J. , vol.7 , pp. 1475-1482
    • Denhardt, D.T.1    Guo, X.2
  • 37
    • 0037088640 scopus 로고    scopus 로고
    • Tumor-derived osteopontin is soluble, not matrix associated
    • Rittling SR, Chen Y, Feng F, Wu Y. Tumor-derived osteopontin is soluble, not matrix associated. J Biol Chem 2002; 277:9175-9182.
    • (2002) J. Biol. Chem. , vol.277 , pp. 9175-9182
    • Rittling, S.R.1    Chen, Y.2    Feng, F.3    Wu, Y.4
  • 38
    • 0035966343 scopus 로고    scopus 로고
    • The metastasis gene osteopontin: A candidate target for cancer therapy
    • 1552
    • Weber GF. The metastasis gene osteopontin: a candidate target for cancer therapy. Biochem Biophys Acta 2001; 1552:61-85.
    • (2001) Biochem. Biophys. Acta , pp. 61-85
    • Weber, G.F.1
  • 39
    • 0035495596 scopus 로고    scopus 로고
    • The role of osteopontin in breast cancer: Clinical and experimental studies
    • Tuck AB, Chambers AF. The role of osteopontin in breast cancer: clinical and experimental studies. J Mammary Gland Biol Neoplasia 2001; 6:419-429.
    • (2001) J. Mammary Gland Biol. Neoplasia , vol.6 , pp. 419-429
    • Tuck, A.B.1    Chambers, A.F.2
  • 42
    • 0034144269 scopus 로고    scopus 로고
    • Chemokines: A new classification system and their role in immunity
    • Zlotnik A, Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity 2000; 12:121-127.
    • (2000) Immunity , vol.12 , pp. 121-127
    • Zlotnik, A.1    Yoshie, O.2
  • 43
    • 0034054496 scopus 로고    scopus 로고
    • Chemokines in tissue-specific and microenvironment-specific lymphocyte homing
    • Campbell JJ, Butcher EC. Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr Opin Immunol 2000; 12:336-341.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 336-341
    • Campbell, J.J.1    Butcher, E.C.2
  • 47
    • 0034658725 scopus 로고    scopus 로고
    • Molecular mechanisms of osteolytic bone metastases
    • Guise TA. Molecular mechanisms of osteolytic bone metastases. Cancer 2000; 88:2892-2898.
    • (2000) Cancer , vol.88 , pp. 2892-2898
    • Guise, T.A.1
  • 48
    • 0034937704 scopus 로고    scopus 로고
    • Role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in bone cell biology
    • Hofbauer LC, Heufelder AE. Role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in bone cell biology. J Mol Med 2001; 79:243-253.
    • (2001) J. Mol. Med. , vol.79 , pp. 243-253
    • Hofbauer, L.C.1    Heufelder, A.E.2
  • 49
    • 0034510162 scopus 로고    scopus 로고
    • Osteoprotegerin and its ligand: A new paradigm for regulation of osteoclastogenesis and bone resorption
    • Aubin JE, Bonnelye E. Osteoprotegerin and its ligand: a new paradigm for regulation of osteoclastogenesis and bone resorption. Osteoporos Int 2000; 11:905-913.
    • (2000) Osteoporos. Int. , vol.11 , pp. 905-913
    • Aubin, J.E.1    Bonnelye, E.2
  • 50
    • 0036218666 scopus 로고    scopus 로고
    • RANK-L and RANK: T cells, bone loss, and mammalian evolution
    • Theill LE, Boyle WJ, Penninger JM. RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol 2002; 20:795-823.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 795-823
    • Theill, L.E.1    Boyle, W.J.2    Penninger, J.M.3
  • 53
    • 0035423780 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor-kappaB ligand and osteoprotegerin: Potential implications for the pathogenesis and treatment of malignant bone diseases
    • Hofbauer LC, Neubauer A, Heufelder AE. Receptor activator of nuclear factor-kappaB ligand and osteoprotegerin: potential implications for the pathogenesis and treatment of malignant bone diseases. Cancer 2001; 92:460-470.
    • (2001) Cancer , vol.92 , pp. 460-470
    • Hofbauer, L.C.1    Neubauer, A.2    Heufelder, A.E.3
  • 55
    • 0023749677 scopus 로고
    • In vivo distribution of parathyroid hormone receptors in bone: Evidence that a predominant osseous target cell is not the mature osteoblast
    • Rouleau MF, Mitchell J, Goltzman D. In vivo distribution of parathyroid hormone receptors in bone: evidence that a predominant osseous target cell is not the mature osteoblast. Endocrinology 1988; 123:187-191.
    • (1988) Endocrinology , vol.123 , pp. 187-191
    • Rouleau, M.F.1    Mitchell, J.2    Goltzman, D.3
  • 56
    • 0034813396 scopus 로고    scopus 로고
    • The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis
    • Borton AJ, Frederick JP, Datto MB, Wang XF, Weinstein RS. The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis. J Bone Miner Res 2001; 16:1754-1764.
    • (2001) J. Bone Miner. Res. , vol.16 , pp. 1754-1764
    • Borton, A.J.1    Frederick, J.P.2    Datto, M.B.3    Wang, X.F.4    Weinstein, R.S.5
  • 59
    • 0036177554 scopus 로고    scopus 로고
    • Nuclear localization of type I parathyroid hormone/parathyroid hormone-related protein receptors in deer antler osteoclasts: Evidence for parathyroid hormone-related protein and receptor activator of NF-kappaB-dependent effects on osteoclast formation in regenerating mammalian bone
    • Faucheux C, Horton MA, Price JS. Nuclear localization of type I parathyroid hormone/parathyroid hormone-related protein receptors in deer antler osteoclasts: evidence for parathyroid hormone-related protein and receptor activator of NF-kappaB-dependent effects on osteoclast formation in regenerating mammalian bone. J Bone Miner Res 2002; 17:455-464.
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 455-464
    • Faucheux, C.1    Horton, M.A.2    Price, J.S.3
  • 61
    • 0032467396 scopus 로고    scopus 로고
    • Human metastatic prostate PC3 cell lines degrade bone using matrix metalloproteinases
    • Sanchez-Sweatman OH, Orr FW, Singh G. Human metastatic prostate PC3 cell lines degrade bone using matrix metalloproteinases. Invasion Metastasis 1998; 18:297-305.
    • (1998) Invasion Metastasis , vol.18 , pp. 297-305
    • Sanchez-Sweatman, O.H.1    Orr, F.W.2    Singh, G.3
  • 62
    • 0030747949 scopus 로고    scopus 로고
    • Direct osteolysis induced by metastatic murine melanoma cells: Role of matrix metalloproteinases
    • Sanchez-Sweatman OH, Lee J, Orr FW, Singh G. Direct osteolysis induced by metastatic murine melanoma cells: role of matrix metalloproteinases. Eur J Cancer 1997; 33:918-925.
    • (1997) Eur. J. Cancer , vol.33 , pp. 918-925
    • Sanchez-Sweatman, O.H.1    Lee, J.2    Orr, F.W.3    Singh, G.4
  • 63
    • 0034455103 scopus 로고    scopus 로고
    • Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
    • Manolagas SC. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev 2000; 21:115-137.
    • (2000) Endocr. Rev. , vol.21 , pp. 115-137
    • Manolagas, S.C.1
  • 66
    • 0030989568 scopus 로고    scopus 로고
    • Technical considerations for studying cancer metastasis in vivo
    • Welch DR. Technical considerations for studying cancer metastasis in vivo. Clin Exptl Metastasis 1997; 15:272-306.
    • (1997) Clin. Exptl. Metastasis , vol.15 , pp. 272-306
    • Welch, D.R.1
  • 68
    • 0031457952 scopus 로고    scopus 로고
    • Animal models of breast cancer: Experimental design and their use in nutrition and psychosocial research
    • Clarke R. Animal models of breast cancer: experimental design and their use in nutrition and psychosocial research. Breast Cancer Res Treat 1997; 46:117-133.
    • (1997) Breast Cancer Res. Treat , vol.46 , pp. 117-133
    • Clarke, R.1
  • 69
    • 0029860590 scopus 로고    scopus 로고
    • Expression of the calcium-binding protein S100A4 (p9Ka) in MMTV- neu transgenic mice induces metastasis of mammary tumours
    • Davies MPA, Rudland PS, Robertson L, Parry EW, Jolicoeur P, Barraclough R. Expression of the calcium-binding protein S100A4 (p9Ka) in MMTV- neu transgenic mice induces metastasis of mammary tumours. Oncogene 1996; 13:1631-1637.
    • (1996) Oncogene , vol.13 , pp. 1631-1637
    • Davies, M.P.A.1    Rudland, P.S.2    Robertson, L.3    Parry, E.W.4    Jolicoeur, P.5    Barraclough, R.6
  • 72
    • 4243895743 scopus 로고    scopus 로고
    • Identification and mapping of a mammary tumor metastasis susceptibility gene
    • U.S. Army Med Res & Material Command Era of Hope Meeting 2
    • LeVoyer T, Lifsted T, Williams M, Hunter K. Identification and mapping of a mammary tumor metastasis susceptibility gene. U.S. Army Med Res & Material Command Era of Hope Meeting 2, 625; 2000.
    • (2000) , pp. 625
    • LeVoyer, T.1    Lifsted, T.2    Williams, M.3    Hunter, K.4
  • 73
    • 0034696336 scopus 로고    scopus 로고
    • Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer
    • Li Y, Hively WP, Varmus HE. Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer. Oncogene 2000; 19:1002-1009.
    • (2000) Oncogene , vol.19 , pp. 1002-1009
    • Li, Y.1    Hively, W.P.2    Varmus, H.E.3
  • 75
    • 0034619771 scopus 로고    scopus 로고
    • Reduced mammary tumor progression in WAP-TAg/WAP-maspin bitransgenic mice
    • Zhang M, Shi Y, Magit D, Furth PA, Sager R. Reduced mammary tumor progression in WAP-TAg/WAP-maspin bitransgenic mice. Oncogene 2000; 19:6053-6058.
    • (2000) Oncogene , vol.19 , pp. 6053-6058
    • Zhang, M.1    Shi, Y.2    Magit, D.3    Furth, P.A.4    Sager, R.5
  • 76
    • 0024262906 scopus 로고
    • A murine model of experimental metastasis to bone and bone marrow
    • Arguello F, Baggs RB, Frantz CN. A murine model of experimental metastasis to bone and bone marrow. Cancer Res 1988; 48:6876-6881.
    • (1988) Cancer Res. , vol.48 , pp. 6876-6881
    • Arguello, F.1    Baggs, R.B.2    Frantz, C.N.3
  • 77
    • 0034912833 scopus 로고    scopus 로고
    • A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro
    • Yoneda T, Williams PJ, Hiraga T, Niewolna M, Nishimura R. A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro. J Bone Miner Res 2001; 16:1486-1495.
    • (2001) J. Bone Miner. Res. , vol.16 , pp. 1486-1495
    • Yoneda, T.1    Williams, P.J.2    Hiraga, T.3    Niewolna, M.4    Nishimura, R.5
  • 79
    • 0012944342 scopus 로고    scopus 로고
    • MDA-MB-435 human breast carcinoma metastasis to bone
    • (in press)
    • Harms JF, Welch DR. MDA-MB-435 human breast carcinoma metastasis to bone. Clin Exp Metastasis 2003; (in press).
    • (2003) Clin. Exp. Metastasis
    • Harms, J.F.1    Welch, D.R.2
  • 80
    • 0034213656 scopus 로고    scopus 로고
    • Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13
    • Seraj MJ, Samant RS, Verderame MF, Welch DR. Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13. Cancer Res 2000; 60:2764-2769.
    • (2000) Cancer Res. , vol.60 , pp. 2764-2769
    • Seraj, M.J.1    Samant, R.S.2    Verderame, M.F.3    Welch, D.R.4
  • 82
    • 0012945933 scopus 로고    scopus 로고
    • Identification and characterization of mouse homolog (Brms1) of the breast cancer metastasis suppressor BRMS1
    • Samant RS, Debies MT, Shevde LA, Welch DR. Identification and characterization of mouse homolog (Brms1) of the breast cancer metastasis suppressor BRMS1. Proc Amer Assoc for Cancer Res 2001; 42:2808.
    • (2001) Proc. Amer. Assoc. for Cancer Res. , vol.42 , pp. 2808
    • Samant, R.S.1    Debies, M.T.2    Shevde, L.A.3    Welch, D.R.4
  • 83
    • 0012945934 scopus 로고    scopus 로고
    • Suppression of human melanoma metastasis by breast metastasis suppressor [BRMS1]
    • Shevde LA, Samant RS, Welch DR. Suppression of human melanoma metastasis by breast metastasis suppressor [BRMS1]. Proc Amer Assoc for Cancer Res 2001; 42:646.
    • (2001) Proc. Amer. Assoc. for Cancer Res. , vol.42 , pp. 646
    • Shevde, L.A.1    Samant, R.S.2    Welch, D.R.3
  • 85
    • 0030956852 scopus 로고    scopus 로고
    • Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1
    • Lee J-H, Welch DR. Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1. Cancer Res 1997; 57:2384-2387.
    • (1997) Cancer Res. , vol.57 , pp. 2384-2387
    • Lee, J.-H.1    Welch, D.R.2
  • 86
    • 0012943359 scopus 로고
    • Metastasis, but not tumorigenicity, is suppressed and nm23 levels are increased by introduction of chromosome 6 into human malignant melanoma cell line C8161
    • Miele ME, Gresham VC, Stanbridge EJ, Weissman BE, Welch DR. Metastasis, but not tumorigenicity, is suppressed and nm23 levels are increased by introduction of chromosome 6 into human malignant melanoma cell line C8161. Proc Amer Assoc for Cancer Res 1994; 35:325.
    • (1994) Proc. Amer. Assoc. for Cancer Res. , vol.35 , pp. 325
    • Miele, M.E.1    Gresham, V.C.2    Stanbridge, E.J.3    Weissman, B.E.4    Welch, D.R.5
  • 87
    • 0028029129 scopus 로고
    • Microcell-mediated transfer of chromosome 6 into metastatic human C8161 melanoma cells suppresses metastasis but does not inhibit tumorigenicity
    • Welch DR, Chen P, Miele ME, McGary CT, Bower JM, Weissman BE, Stanbridge EJ. Microcell-mediated transfer of chromosome 6 into metastatic human C8161 melanoma cells suppresses metastasis but does not inhibit tumorigenicity. Oncogene 1994; 9:255-262.
    • (1994) Oncogene , vol.9 , pp. 255-262
    • Welch, D.R.1    Chen, P.2    Miele, M.E.3    McGary, C.T.4    Bower, J.M.5    Weissman, B.E.6    Stanbridge, E.J.7
  • 88
    • 0033499057 scopus 로고    scopus 로고
    • Metastasis-suppressed C8161 melanoma cells arrest in lung but fail to proliferate
    • Goldberg SF, Harms JF, Quon K, Welch DR. Metastasis-suppressed C8161 melanoma cells arrest in lung but fail to proliferate. Clin Exp Metastasis 1999; 17:601-607.
    • (1999) Clin. Exp. Metastasis , vol.17 , pp. 601-607
    • Goldberg, S.F.1    Harms, J.F.2    Quon, K.3    Welch, D.R.4
  • 90
    • 0033817917 scopus 로고    scopus 로고
    • Defining the biologic role of genes that regulate prostate cancer metastasis
    • Rinker-Schaeffer CW, Welch DR, Sokoloff M. Defining the biologic role of genes that regulate prostate cancer metastasis. Curr Opin Urol 2001; 10:397-401.
    • (2001) Curr. Opin. Urol. , vol.10 , pp. 397-401
    • Rinker-Schaeffer, C.W.1    Welch, D.R.2    Sokoloff, M.3
  • 92
    • 0031600391 scopus 로고    scopus 로고
    • Nm23 and tumour metastasis: Basic and translational advances
    • Freije JM, MacDonald NJ, Steeg PS. Nm23 and tumour metastasis: basic and translational advances. Biochem Soc Symp 1998; 63:261-271.
    • (1998) Biochem. Soc. Symp. , vol.63 , pp. 261-271
    • Freije, J.M.1    MacDonald, N.J.2    Steeg, P.S.3
  • 95
    • 0035266149 scopus 로고    scopus 로고
    • Breast cancer metastatic potential correlates with a breakdown in homospecific and heterospecific gap junctional intercellular communication
    • Saunders MM, Seraj MJ, Li ZY, Zhou ZY, Winter CR, Welch DR, Donahue HJ. Breast cancer metastatic potential correlates with a breakdown in homospecific and heterospecific gap junctional intercellular communication. Cancer Res 2001; 61:1765-1767.
    • (2001) Cancer Res. , vol.61 , pp. 1765-1767
    • Saunders, M.M.1    Seraj, M.J.2    Li, Z.Y.3    Zhou, Z.Y.4    Winter, C.R.5    Welch, D.R.6    Donahue, H.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.