erbB family receptor expression and growth regulation in a newly isolated human breast cancer cell line

Cancer Research

Volumn 56, Issue 4, 1996, Pages 899-907

  Ethier, Stephen P ^a   Kokeny, Kristine E ^a   Ridings, Jane W ^a   Dilts, Cheryl A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR;

ARTICLE; BREAST CANCER; CANCER GROWTH; ENZYME ACTIVITY; GROWTH REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BASE SEQUENCE; BLOTTING, WESTERN; BREAST; BREAST NEOPLASMS; CELL DIVISION; CELL LINE; DNA PRIMERS; FEMALE; GENE EXPRESSION; GENES, ERBB-2; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; PHOSPHOTYROSINE; PLEURAL EFFUSION; POLYMERASE CHAIN REACTION; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECEPTOR, ERBB-3; RNA, MESSENGER; TUMOR CELLS, CULTURED; VANADATES;

EID: 0030041756     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Petersen, O. W , and van Deurs, B. Preservation of defined phenotypic traits in short-term cultured human breast carcinoma derived epithelial cells. Cancer Res., 47: 856-866, 1987.
2. Petersen, O. W., van Deurs, B., Nielsen, K. V., Madsen, M. W., Laursen, I., Balslev, I., and Briand, P. Differential tumorigenicity of two autologous human breast carcinoma cell lines, HMT-3909S1 and HMT-3909S8, established in serum-free medium. Cancer Res., 50: 1257-1270, 1990.
3. Band, V., Zajchowski, D., Swisshelm, D., Trask, D., Kulesa, V., Cohen, C., Connolly, J., and Sager, R Tumor progression in four mammary epithelial cell lines derived from the same patient. Cancer Res , 50: 7351-7357, 1990.
4. Meltzer, P., Leibovitz, A., Dalton, W , Villar, H., Kute, T., Davis, J., Nagle, R., and Trent, J. Establishment of two new cell lines derived from human breast carcinomas with HER-2/neu amplification. Br. J. Cancer, 63: 727-735, 1991.
5. Ram, T. G., Dilts, C. A , Dziubinski, M. L , Pierce, L J., and Ethier, S. P. Insulin-like growth factor and epidermal growth factor independence in human mammary carcinoma cells with c-erbB-2 gene amplification and progressively elevated levels of tyrosine phosphorylated erbB-2. Mol. Carcinog , in press, 1996.
6. Mahacek, M. L., Beer, D. G., Frank, T. S., and Ethier, S. P Finite proliferative lifespan in vitro of a human breast cancer cell strain isolated from a metastatic lymph node. Breast Cancer Res. Treat., 28 267-276, 1993
7. Ethier, S P., Mahacek, M. L., Gullick, W. J., Frank, T. J., and Weber, B. L. Differential isolation of normal luminal mammary epithelial cells and breast cancer cells from primary and metastatic sites using selective media. Cancer Res., 53: 627-635, 1993.
8. Holmes, W. E., Sliwkowski, M. X., Akita, R. W., Henzel, W. J., Lee, J., Park, J. W., Yansura, D , Abadi, N., Raab, H., Lewis, G. D., Shepard, M., Kuang, W-J., Wood, W. I., Goeddel, D. V., and Vandlen, R. L Identification of heregulin, a specific activator of p185erb2 Science (Washington DC), 256. 1205-1210, 1992.
9. Kraus, M. H., Issing, W., Miki, T., Popescu, N C., and Aaronson, S. A. Isolation and characterization of ERB-B-3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc. Natl Acad Sci. USA, 86: 9193-9197, 1989.
10. Plowman, G. D , Culouscou, J M., Whitney, G. S., Green, J. M., Carlton, G. W., Foy, L., Neubauer, M. G., and Shoyab, M. Ligand-Specific activation of HER4/ p180(erbB4), a 4th member of the epidermal growth factor receptor family Proc Natl. Acad. Sci. USA, 90: 1746-1750, 1993.
11. Butler, W B Preparing nuclei from cells in monolayer cultures suitable for counting and for following synchronized cells through the cell cycle. Anal. Biochem., 141: 70-73, 1984.
12. Wen, D., Peles, E., Cupples, R., Suggs, S Bacus, S. S., Luo, Y., Trail, G., Hu, S., Silbiger, S., Levy, R. B., Koski, R , Lu, H. S., and Yarden, Y. Neu differentiation factor, a transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit. Cell, 69: 559-572, 1992.
13. Peles, E., Benlevy, R., Tzahar, E., Liu, N L , Wen, D. Z., and Yarden, Y. Cell-type specific interaction of Neu differentiation factor (NDF heregulin) with Neu/HER-2 suggests complex ligand receptor relationships. EMBO J., 12:961-971, 1993.
14. Sliwkowski, M. X., Schaefer, G., Akita, R. W. Lofgren, J. A., Fitzpatrick, V. D., Nuijens, A., Fendly, B. M., Cerione, R. A., Vandlen, R. L., and Carraway, K. L. Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin. J Biol. Chem., 269: 14661-14665, 1994.
15. Ethier, S P., Moorthy, R., and Dilts, C. A. Secretion of an epidermal growth factor-like growth factor by epidermal growth factor-independent rat mammary carcinoma cells. Cell Growth & Differ., 2: 593-602, 1991.
16. Ram, T. G., Kokeny, K. E., Dilts, C. A., and Ethier, S. P. Mitogenic activity of neu differentiation factor/heregulin mimics that of epidermal growth factor and insulin-like growth factor-I in human mammary epithelial cells. J. Cell. Physiol., 163: 589-596, 1995.
17. Ethier, S. P , Langton, B. C., and Dilts, C A. Growth factor-independent proliferation of rat mammary carcinoma cells by autocrine secretion of neu-differentiation factor/ heregulin and transforming growth factor-α Mol Carcinog., in press, 1996.
18. Shawver, L. K , Mann, E., Elliger, S. S., Dugger, T. C., and Arteaga, C. L. Ligand-like effects of anti-c-erbB-2 antibodies do not correlate with and are not required for growth inhibition of human carcinoma cells Cancer Res., 54: 1367-1373, 1994.
19. Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A., and McGuire, W. L. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene Science (Washington DC), 235. 177-182, 1987.
20. van de Vijver, M., van de Bersselaar, R., Devilee, P., Cornelisse, C., Peterse, J., and Nusse, R. Amplification of the neu (c-erbB-2) oncogene in human mammary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene. Mol. Cell. Biol., 7: 2019-2023, 1987.
21. Wright, C., Angus, B., Nicholson, S., Sainsbury, J. R. C., Cairns, J , Gullick, W. J., Kelly, P., Harris, A. L., and Horne, C. H W Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer. Cancer Res., 49: 2087-2090, 1989.
22. Paterson, M C., Dietrich, K. D , Danyluk, J., Paterson, A. H. G., Lees, A W., Jamil, N., Hanson, J., Jenkins, H., Krause, B. E., McBlain, W. A., Slamon, D. J., and Fourney, R M. Correlation between c-erbB-2 amplification and risk of recurrent disease in node-negative breast cancer. Cancer Res , 51. 556-567, 1991
23. Wildenhain, Y., Pawson, T., Blackstein, M. E., and Andrulis, I. L. p185neu is phosphorylated on tyrosine in human primary breast tumors which overexpress neu/erbB-2. Oncogene, 5. 879-883, 1990
24. Kraus, M. H., Fedi, P., Starks, V., Muraro, R., and Aaronson, S. A Demonstration of ligand-dependent signaling by the erbB-3 tyrosine kinase and its constitutive activation in human breast tumor cells. Proc. Natl. Acad. Sci USA, 90: 2900-2904, 1993.
25. Goldstein, B J. Protein-tyrosine phosphatases and the regulation of insulin action J. Cell Biochem., 48: 33-42, 1992.
26. Faure, R., Baquiran, G., Bergeron, J J. M , and Posner, B. I. The dephosphorylation of insulin and epidermal growth factor receptors: role of endosome-associated phosphotyrosine phosphatase(s). J. Biol. Chem., 207 11215-11221, 1992.
27. Gruppuso, P A , Mikumo, R., Brautigan, D. L., and Braun, L. Growth arrest induced by transforming growth factor-β-1 is accompanied by protein phosphatase activation in human keratinocytes. J Biol Chem., 266: 3444-3448, 1991.
28. Kulas, D. T., Zhang, W R , Goldstein, B. J., Furlanetto, R. W., and Mooney, R. A. Insulin receptor signaling is augmented by antisense inhibition of the protein tyrosine phosphatase LAR J. Biol. Chem , 270: 2435-2438, 1995.
29. Meyerovitch, J., Backer, J. M., Csermely, P., Shoelson, S. E., and Kahn, C R. Insulin differentially regulates protein phosphotyrosine phosphatase Activity in rat hepatoma cells Biochemistry, 31: 10338-10344, 1992.
30. Klingmuller, U., Lorenz, U., Cantley, L. C., Neel, B. G., and Lodish, H F. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferate signals. Cell, 80: 729-738, 1995.