Inhibitors of protein tyrosine phosphorylation reduce the proliferation of two human glioma cell lines

Neurosurgery

Volumn 38, Issue 1, 1996, Pages 108-114

  Oude Weernink, Paschal A ^a   Verheul, Edith ^a   Kerkhof, Ellen ^a   Van Veelen, Cornelis W M ^a   Rijksen, Gert ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Glioma; Growth factors; Tyrosine kinase inhibitors; Tyrosine phosphorylation; Tyrphostins

Indexed keywords

ALPHA (3,4 DIMETHOXYBENZYLIDENE) 2 PYRIDYLACETONITRILE; EPIDERMAL GROWTH FACTOR; GENISTEIN; GROWTH FACTOR; INSULIN; PLATELET DERIVED GROWTH FACTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RG 50875; SOMATOMEDIN C; TYRPHOSTIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM TUMOR; DNA SYNTHESIS; ENZYME INHIBITION; GLIOBLASTOMA; GLIOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; CELL DIVISION; CELL SURVIVAL; DNA REPLICATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIDERMAL GROWTH FACTOR; GENISTEIN; GLIOBLASTOMA; GLIOMA; HUMANS; ISOFLAVONES; PLATELET-DERIVED GROWTH FACTOR; PROTEIN-TYROSINE KINASES; TUMOR CELLS, CULTURED;

EID: 9044228411     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006123-199601000-00026     Document Type: Article

References (33)

1. Akbasak A, Sunar-Akbasak B: Oncogenes: Cause or consequence in the development of glial tumors. J Neurol Sci 111:119-133, 1992.
2. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N, Shibuya M, Fukami Y: Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262:5592-5595, 1987.
3. Bilder GE, Krawiec JA, McVety K, Gazit A, Gilon C, Lyall R, Zilberstein A, Levitzki A, Perrone MH, Schreiber AB: Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells. Am J Physiol 260:C721-C730, 1991.
4. Fleming TP, Saxena A, Clark WC, Robertson JT, Oldfield EH, Aaronson SA, Ali IU: Amplification and/or overexpression of plateletderived growth factor receptors and epidermal growth factor receptor in human glial tumors. Cancer Res 52:4550-4553, 1992.
5. Gazit A, Yaish P, Gilon C, Levitzki A: Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 32:2344-2352, 1989.
6. Gillaspy GE, Mapstone TB, Samols D, Goldthwait DA: Transcriptional patterns of growth factors and proto-oncogenes in human glioblastomas and normal glial cells. Cancer Lett 65:55-60, 1992.
7. Levitzki A: Tyrphostins: Potential antiproliferative agents and novel molecular tools. Biochem Pharmacol 40:913-918, 1990.
8. Libermann TA, Nusbaum HR, Razon N, Kris R, Lax I, Soreq H, Whittle N, Waterfield MD, Ullrich A, Schlessinger J: Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature 313:144-147, 1985.
9. Lyall RM, Zilberstein A, Gazit A, Gilon C, Levitzki A, Schlessinger J: Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation. J Biol Chem 264:14503-14509, 1989.
10. Mapstone TB: Expression of platelet-derived growth factor and transforming growth factor and their correlation with cellular morphology in glial tumors. J Neurosurg 75:447-451, 1991.
11. Markovits J, Linassier C, Fossé P, Couprie J, Pierre J, JacqueminSablon A, Saucier J-M, Le Pecq J-B, Larsen AK: Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II. Cancer Res 49:5111-5117, 1989.
12. Maruno M, Kovach JS, Kelly PJ, Yanagihara T: Transforming growth factor-α, epidermal growth factor receptor, and proliferating potential in benign and malignant gliomas. J Neurosurg 75:97-102, 1991.
13. Miyaji K, Tani E, Shindo H, Nakano A, Tokunaga T: Effect of tyrphostin on cell growth and tyrosine kinase activity of epidermal growth factor receptor in human gliomas. J Neurosurg 81: 411-419, 1994.
14. Nistér M, Claesson-Welsh L, Eriksson A, Heldin C-H, Westermark B: Differential expression of platelet-derived growth factor receptors in human malignant glioma cell lines. J Biol Chem 266:16755-16763, 1991.
15. Nistér M, Libermann TA, Betsholtz C, Pettersson M, ClaessonWelsh L, Heldin C-H, Schlessinger J, Westermark B: Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-α and their receptors in human malignant glioma cell lines. Cancer Res 48:3910-3918, 1988.
16. Nistér M, Wedell B, Betsholtz C, Bywater M, Pettersson M, Westermark B, Mark J: Evidence for progressional changes in the human malignant glioma line U-343 MGa: Analysis of karyotype and expression of genes encoding the subunits chains of plateletderived growth factor. Cancer Res 47:4953-4960, 1987.
17. Oliver MH, Harrison NK, Bishop JE, Cole PJ, Laurent GJ: A rapid and convenient assay for counting cells cultured in microwell plates: Application for assessment of growth factors. J Cell Sci 92:513-518, 1989.
18. Pelletier B, Dhainaut F, Pauly A, Zahnd J-P: Evaluation of growth rate in adhering cell cultures using a simple colorimetric method. J Biochem Biophys Methods 16:63-74, 1988.
19. Pollack IF, Randall MS, Kristofik MP, Kelly RH, Selker RG, Vertosick FT Jr: Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium. J Neurosurg 73:106-112, 1990.
20. Pollack IF, Randall MS, Kristofik MP, Kelly RH, Selker RG, Vertosick FT Jr: Response of low-passage human malignant gliomas in vitro to stimulation and selective inhibition of growth factormediated pathways. J Neurosurg 75:284-293, 1991.
21. Ramdas L, McMurray JS, Budde RJA: The degree of inhibition of protein tyrosine kinase activity by tryphostin 23 and 25 is related to their instability. Cancer Res 54:867-869, 1994.
22. Reddy KB, Mangold GL, Tandon AK, Yoneda T, Mundy GR, Zilberstein A, Osborne CK: Inhibition of breast cancer cell growth in vitro by a tyrosine kinase inhibitor. Cancer Res 52:3636-3641, 1992.
23. Sauro MD, Thomas B: Tyrphostin attenuates platelet-derived growth factor-induced contraction in aortic smooth muscle through inhibition of protein tyrosine kinase(s). J Pharmacol Exp Ther 267:1119-1125, 1993.
24. Steck PA, Lee P, Hung M-C, Yung WKA: Expression of an altered epidermal growth factor receptor by human glioblastoma cells. Cancer Res 48:5433-5439, 1988.
25. Stephan EB, Dziak R: Effects of genistein, tyrphostin, and pertussis toxin on EGF-induced mitogenesis in primary culture and clonal osteoblastic cells. Calcif Tissue Int 54:409-413, 1994.
26. Strawn LM, Mann E, Elliger SS, Chu LM, Germain LL, Niederfellner G, Ullrich A, Shawver LK: Inhibition of glioma cell growth by a truncated platelet-derived growth factor-β receptor. J Biol Chem 269:21215-21222, 1994.
27. van Erp HE, Rijksen G, van Veelen CWM, van der Heijden JHW, Maarschalkerweerd BNB, Staal GEJ: Protein tyrosine kinases in human brain and gliomas. J Neurochem 58:554-561, 1992.
28. Vassbotn FS, Östman A, Langeland N, Holmsen H, Westermark B, Heldin C-H, Nistér M: Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line. J Cell Physiol 158:381-389, 1994.
29. Westphal M, Herrmann H-D: Growth factor biology and oncogene activation in human gliomas and their implications for specific therapeutic concepts. Neurosurgery 25:681-694, 1989.
30. Wong A, Bigner SH, Bigner DD, Kinzler KW, Hamilton SR, Vogelstein B: Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sei U S A 84:6899-6903, 1987.
31. Wong AJ, Ruppert JM, Bigner SH, Grzeschik CH, Humphrey PA, Bigner DS, Vogelstein B: Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc Natl Acad Sci U S A 89:2965-2969, 1992.
32. Yaish P, Gazit A, Gilon C, Levitzki A: Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 242: 933-935, 1988.
33. Yoneda T, Lyall RM, Alsina MM, Persons PE, Spada AP, Levitzki A, Zilberstein A, Mundy GR: The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice. Cancer Res 51:4430-4435, 1991.