Delphinidin inhibits HER2 and Erk1/2 signaling and suppresses growth of HER2-overexpressing and triple negative breast cancer cell lines

Breast Cancer: Basic and Clinical Research

Volumn 5, Issue 1, 2011, Pages 143-154

  Ozbay, Tuba ^a   Nahta, Rita ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Breast cancer; Delphinidin; ErbB2; HER2; Triple negative

Indexed keywords

DELPHINIDIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TETRAZOLIUM;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER SURVIVAL; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA FRAGMENTATION; DRUG ANTAGONISM; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; IMMUNOBLOTTING; IN VITRO STUDY; MOLECULAR DYNAMICS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TRIPLE NEGATIVE BREAST CANCER;

EID: 80053609941     PISSN: 11782234     EISSN: None     Source Type: Journal    
DOI: 10.4137/BCBCR.S7156     Document Type: Article

References (26)

1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277-300.
2. Voduc KD, Cheang MC, Tyldesley S, Gelmon K, et al. Breast cancer subtypes and the risk of local and regional relapse. J Clin Oncol. 2010;28:1684-91.
3. Millar EK, Graham PH, O'Toole SA, McNeil CM, et al. Prediction of local recurrence, distant metastases, and death after breast-conserving therapy in early-stage invasive breast cancer using a five-biomarker panel. J Clin Oncol. 2009;27:4701-8.
4. Nguyen PL, Taghian AG, Katz MS, Niemierko A, et al. Breast cancer subtype approximated by estrogen receptor, progesterone receptor, and HER-2 is associated with local and distant recurrence after breast-conserving therapy. J Clin Oncol. 2008;26:2373-8.
5. Haffty BG, Yang Q, Reiss M, Kearney T, et al. Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer. J Clin Oncol. 2006;24:5652-7.
6. Prior RL. Fruits and vegetables in the prevention of cellular oxidative DNA damage. Am J Clin Nutr. 2003;78:570S-8.
7. Hafeez BB, Siddiqui IA, Asim M, Malik A, et al. A dietary anthocyanidin delphinidin induces apoptosis of human prostate cancer PC3 cells in vitro and in vivo: involvement of nuclear factor-kappaB signaling. Cancer Res. 2008;68:8564-72.
8. Lazzè MC, Savio M, Pizzala R, Cazzalini O, et al. Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines. Carcinogenesis. 2004;25:1427-33.
9. Zhang Y, Vareed SK, Nair MG. Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and vegetables. Life Sci. 2005;76:1465-72.
10. Bin Hafeez B, Asim M, Siddiqui IA, Adhami VM, et al. Delphinidin, a dietary anthocyanidin in pigmented fruits and vegetables: a new weapon to blunt prostate cancer growth. Cell Cycle. 2008;7:3320-6.
11. Yun JM, Afaq F, Khan N, Mukhtar H. Delphinidin, an anthocyanidin in pigmented fruits and vegetables, induces apoptosis and cell cycle arrest in human colon cancer HCT116 cells. Mol Carcinog. 2009;48:260-70.
12. Hou DX, Kai K, Li JJ, Lin S, et al. Anthocyanidins inhibit activator protein 1 activity and cell transformation: structure-activity relationship and molecular mechanisms. Carcinogenesis. 2004;25:29-36.
13. Kang NJ, Lee KW, Kwon JY, Hwang MK, et al. Delphinidin attenuates neoplastic transformation in JB6 Cl41 mouse epidermal cells by blocking Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling. Cancer Prev Res (Phila Pa). 2008;1:522-31.
14. Meiers S, Kemény M, Weyand U, Gastpar R, et al. The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor. J Agric Food Chem. 2001;49:958-62.
15. Nagao M, Ushijima T, Wakabayashi K, Ochiai M, et al. Dietary carcinogens and mammary carcinogenesis. Induction of rat mammary carcinomas by administration of heterocyclic amines in cooked foods. Cancer. 1994;74:1063-9.
16. Creton SK, Zhu H, Gooderham NJ. The cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine activates the extracellular signal regulated kinase mitogen-activated protein kinase pathway. Cancer Res. 2007;67:11455-62.
17. Fernandes I, Faria A, Azevedo J, Soares S, et al. Influence of anthocyanins, derivative pigments and other catechol and pyrogallol-type phenolics on breast cancer cell proliferation. J Agric Food Chem. 2010;58:3785-92.
18. Kwon JY, Lee KW, Kim JE, Jung SK, et al. Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MAPKK4 and PI-3 kinase. Carcinogenesis. 2009;30:1932-40.
19. Ito N, Hasegawa R, Sano M, Tamano S, et al. A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis. 1991;12:1503-6.
20. Hasegawa R, Sano M, Tamano S, Imaida K, et al. Dose-dependence of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) carcinogenicity in rats. Carcinogenesis. 1993;14:2553-7.
21. Shirai T, Sano M, Tamano S, Takahashi S, et al. The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods. Cancer Res. 1997;57:195-8.
22. Hirose M, Akagi K, Hasegawa R, Yaono M, et al. Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats. Carcinogenesis. 1995;16:217-21.
23. Fridrich D, Teller N, Esselen M, Pahlke G, Marko D. Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation. Mol Nutr Food Res. 2008;52:815-22.
24. Teller N, Thiele W, Boettler U, Sleeman J, Marko D. Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family. Mol Nutr Food Res. 2009;53:1075-83.
25. Miyazawa T, Nakagawa K, Kudo M, Muraishi K, Someya K. Direct intestinal absorption of red fruit anthocyanins, cyanidin-3-glucoside and cyanidin-3,5-diglucoside, into rats and humans. J Agric Food Chem. 1999;47:1083-91.
26. Seeram NP, Zhang Y, Nair MG. Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins. Nutr Cancer. 2003;46:101-6.