Transgenic Neospora caninum strains constitutively expressing the bradyzoite NcSAG4 protein proved to be safe and conferred significant levels of protection against vertical transmission when used as live vaccines in mice

Vaccine

Volumn 29, Issue 44, 2011, Pages 7867-7874

  Marugan Hernandez V ^a   Ortega Mora, L M ^a   Aguado Martinez A ^a   Jimenez Ruiz E ^a   Alvarez Garcia G ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Live vaccine; NcSAG4; Neospora caninum; Pregnant mouse model; Safety; Transgenic strains

Indexed keywords

ANTIGEN; LIVE VACCINE; NCSAG4 ANTIGEN; PROTOZOAL PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; BRADYZOITE; BRAIN INFECTION; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; MORTALITY; MOUSE; NEOSPORA CANINUM; NEOSPOROSIS; NONHUMAN; PRIORITY JOURNAL; PUP (RODENT); TACHYZOITE; TH1 CELL; TH2 CELL; VERTICAL TRANSMISSION;

ANIMALS; ANTIGENS, PROTOZOAN; COCCIDIOSIS; FEMALE; GENE EXPRESSION; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MICE; NEOSPORA; ORGANISMS, GENETICALLY MODIFIED; PREGNANCY; PREGNANCY COMPLICATIONS, PARASITIC; PROTOZOAN PROTEINS; PROTOZOAN VACCINES; SURVIVAL ANALYSIS; VACCINES, ATTENUATED;

EID: 80053581952     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2011.07.091     Document Type: Article

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