Vaccination of mice against experimental Neospora caninum infection using NcSAG1 - and NcSRS2-based recombinant antigens and DNA vaccines

Parasitology

Volumn 126, Issue 4, 2003, Pages 303-312

  Cannas, A ^a   Naguleswaran, A ^a   Muller N ^a   Eperon, S ^b   Gottstein, B ^a   Hemphill, A ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b Ophthalmic Hospital   (Switzerland)

Author keywords

Neospora caninum; Neosporosis; Quantitative PCR; Serology; Surface antigens; Vaccination

Indexed keywords

DNA VACCINE; HYBRID PROTEIN; RECOMBINANT ANTIGEN; RECOMBINANT NCSAG1 ANTIGEN; RECOMBINANT NCSRS2 ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APATHY; ARTICLE; BRAIN INFECTION; CONTROLLED STUDY; ESCHERICHIA COLI; FEMALE; GAIT DISORDER; MOUSE; NEOSPORA CANINUM; NONHUMAN; PARALYSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTOZOAL INFECTION; SEROLOGY; VACCINATION;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; BRAIN; COCCIDIOSIS; DISEASE MODELS, ANIMAL; MICE; NEOSPORA; PROTOZOAN VACCINES; VACCINATION; VACCINES, DNA; VACCINES, SYNTHETIC;

ANIMALIA; ESCHERICHIA COLI; EUKARYOTA; NEOSPORA CANINUM; PROTOZOA;

EID: 0037396665     PISSN: 00311820     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0031182002002895     Document Type: Article

References (32)

1. ANDRIANARIVO, A. G., CHOROMANSKI, L., McDONOUGH, S. P., PACKHAM, A. E. & CONRAD, P. A. (1999). Immunogenicity of a killed whole Neospora caninum tachyzoite preparation formulated with different adjuvants. International Journal for Parasitology 29, 1613-1625.
2. ANDRIANARIVO, A. G., ROWE, J. D., BARR, B. C., ANDERSON, M. L. PACKHAM, A. E., SVERLOW, K. W., CHOROMANSKI, L., LOUIE, C., GRACE, A. & CONRAD, P. A. (2000). A POLYGEN™-adjuvanted killed Neospora caninum tachyzoite preparation failed to prevent foetal infection in pregnant cattle following i.v/i.m experimental tachyzoite challenge. International Journal for Parasitology 30, 985-990.
3. COLE, R. A., LINDSAY, D. S., BLAGBURN, B. L. & DUBEY, J. P. (1995). Vertical transmission of Neospora caninum in mice. Journal of Parasitology 81, 730-732.
4. DUBEY, J. P., HATTEL, A. L., LINDSAY, D. S. & TOPPER, M. J. (1988). Neonatal Neospora caninum infection in dogs: isolation of the causative agent and experimental transmission. Journal of the American Veterinary Medical Association 193, 1259-1263.
5. DUBEY, J. P. & LINDSAY, D. S. (1996). A review of Nespora caninum and neosporosis. Veterinary Parasitology 67, 1-59.
6. EPERON, S., BRÖNNIMANN, K., HEMPHILL, A. & GOTTSTEIN, B. (1999). Susceptibility of B-cell deficient C57BL/6 (μMT) mice to Neospora caninum infection. Parasite Immunology 21, 225-236.
7. FUCHS, N., SONDA, S., GOTTSTEIN, B. & HEMPHILL, A. (1998). Differential expression of cell surface- and dense granule-associated Neospora caninum proteins in tachyzoites and bradyzoites. Journal of Parasitology 84, 753-758.
8. GOTTSTEIN, B., EPERON, S., DAI, W. J., HEMPHILL, A. & GREIF, G. (2001). Efficacy of toltrazuril and ponazuril against experimental Neospora caninum infection in mice. Parasitology Research 87, 43-48.
9. HEMPHILL, A. (1996). Subcellular localization and functional characterisation of Nc-p43, a major Neospora caninum tachyzoite surface protein. Infection and Immunity 64, 4279-4287.
10. HEMPHILL, A. (1999). The host-parasite relationship in neosporosis. Advances in Parasitology 43, 47-104.
11. HEMPHILL, A. & GOTTSTEIN, B. (2000). A European perspective on Neospora caninum. International Journal for Parasitology 30, 877-924.
12. HEMPHILL, A., GOTTSTEIN, B. & KAUFMANN, H. (1996). Adhesion and invasion of bovine endothelial cells by Neospora caninum tachyzoites. Parasitology 112, 183-197.
13. HEMPHILL, A., FELLEISEN, R., CONNOLLY, B., GOTTSTEIN, B., HENTRICH, B. & MÜLLER, N. (1997). Characterization of a cDNA clone encoding Nc-p43, a major Neospora caninum surface protein. Parasitology 115, 581-590.
14. HOWE, D. K., CRAWFORD, A. C., LINDSAY, D. L. & SIBLEY, L. D. (1998). The p29 and p35 immunodominant antigens of Neospora caninum tachyzoites are homologous to the family of surface antigens of Toxoplasma gondii. Infection and Immunity 66, 5322-5328.
15. INNES, E. A., ANDRIANARIVO, A. G., BJORKMAN, C., WILLIAMS, D. J. & CONRAD, P. A. (2002). Immune responses to Neospora caninum and prospects for vaccination. Trends in Parasitology 18, 497-504.
16. KAHN, I. A., SCHWARTZMAN, J. D., FONSEKA, S. & KAPSER, L. H. (1997). Neospora caninum: role for immune cytokines in host immunity. Experimental Parasitology 85, 24-34.
17. LALLY, N., JENKINS, M., LIDELL, S. & DUBEY, J. P. (1997). A dense granule protein (NCDG1) gene from Neospora caninum. Molecular and Biochemical Parasitology 87, 239-243.
18. LIDDELL, S., LALLY, N., JENKINS, M. C. & DUBEY, J. P. (1998). Isolation of the cDNA encoding a dense granule associated antigen (NCDG2) of Neospora caninum. Molecular and Biochemical Parasitology 93, 153-158.
19. LIDDELL, S., JENKINS, M. C., COLLICA, M. C. & DUBEY, J. P. (1999). Prevention of vertical transfer of Neospora caninum in BALB/c mice by vaccination. Journal of Parasitology 85, 1072-1075.
20. LINDSAY, D. S. & DUBEY, J. P. (1989). Neospora caninum (Protozoa: Apicomplexa) infections in mice. Journal of Parasitology 75, 772-779.
21. LINDSAY, D. S., LENZ, S. D., COLE, R. A., DUBEY, J. P. & BLAGBURN, B. L. (1995). Mouse model for central nervous system Neospora caninum infections. Journal of Parasitology 81, 313-315.
22. LONG, M. T. & BASZLER, T. V. (1996). Fetal loss in BALB/c mice infected with Neospora caninum. Journal of Parasitology 82, 608-611.
23. LONG, M. T., BASZLER, T. V. & MATHISON, B. A. (1998). Comparison of intracerebral parasite load, lesion development, and systemic cytokines in mouse strains infected with Neospora caninum. Journal of Parasitology 84, 316-320.
24. LOUIE, K. & CONRAD, P. A. (1999). Characterization of a cDNA encoding a subtilisin-like serine protease (NC-p65) of Neospora caninum. Molecular and Biochemical Parasitology 103, 211-223.
25. McGUIRE, A. M., McALLISTER, M. M., JOLEEY, W. R. & ANDERSON SPRECHER, R. C. (1997). A protocol for the production of Neospora caninum tissue cysts in mice. Journal of Parasitology 83, 647-651.
26. MÜLLER, N., ZIMMERMANN, V., HENTRICH, B. & GOTTSTEIN, B. (1996). Diagnosis of Neospora caninum and Toxoplasma gondii infection by PCR and DNA hybridization immunoassay. Journal of Clinical Microbiology 34, 2850-2852.
27. MÜLLER, N., VONLAUFEN, N., GIANINAZZI, C., LEIB, S. L. & HEMPHILL, A. (2002). Application of real time fluorescent PCR for quantitative assessment of Neospora caninum infections in organotypic slice cultures of rat central nervous tissue. Journal of Clinical Microbiology 40, 252-255.
28. NISHIKAWA, Y., XUAN, X., NAGASAWA, H., IGARASHI, I., FUJISAKA, K., OTSUKA, H. & MIKAMI, T. (2000). Monoclonal antibody inhibition of Neospora caninum tachyzoite invasion into host cells. International Journal for Parasitology 30, 51-58.
29. NISHIKAWA, Y., INOUE, N., XUAN, X., NAGASAWA, H., IGARASHI, I., FIJISAKI, K., OTSUKA, H. & MIKAMI, T. (2001). Protective efficacy of vaccination by recombinant vaccinia virus against Neospora caninum infection. Vaccine 19, 1381-1390.
30. SONDA, S., FUCHS, N., CONNOLLY, B., FERNANDEZ, P., GOTTSTEIN, B. & HEMPHILL, A. (1998). The major 36 kDa Neospora caninum tachyzoite surface protein is closely related to the major Toxoplasma gondii surface antigen 1. Molecular and Biochemical Parasitology 97, 97-108.
31. SONDA, S., FUCHS, N., GOTTSTEIN, B. & HEMPHILL, A. (2000). Molecular characterization of a novel microneme antigen in Neospora caninum. Molecular and Biochemical Parasitology 108, 39-51.
32. WESSEL, D. & FLUEGGE, U. I. (1984). A method for the quantitative recovery of protein in dilute solution in the presence of detergent. Analytical Biochemistry 138, 141-143.