Diverse role of conformational dynamics in carboxypeptidase A-driven peptide and ester hydrolyses: Disclosing the "perfect Induced Fit" and "protein Local Unfolding" pathways by altering protein stability

Biopolymers

Volumn 95, Issue 12, 2011, Pages 852-870

  Shushanyan, Mikhael ^a,b,c   Khoshtariya, Dimitri E ^a,b,c   Tretyakova, Tatyana ^b,c   Makharadze, Maya ^b,c   Van Eldik, Rudi ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b TBILISI STATE UNIVERSITY   (Georgia)

^c LEPL Life Science Research Center   (Georgia)

Author keywords

activation parameters; carboxypeptidase A; catalytic mechanisms; conformational dynamics; protein stabilization destabilization; substrate activation inhibition

Indexed keywords

ACTIVATION PARAMETER; CARBOXYPEPTIDASE A; CATALYTIC MECHANISMS; CONFORMATIONAL DYNAMICS; PROTEIN STABILIZATION/ DESTABILIZATION; SUBSTRATE ACTIVATION/INHIBITION;

CURVE FITTING; DYNAMICS; ESTERIFICATION; ESTERS; HYDROLYSIS; PEPTIDES; REACTION RATES; UREA;

SUBSTRATES;

CARBOXYPEPTIDASE A; ESTER; PEPTIDE; TRIMETHYLAMINE OXIDE; UREA;

ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STABILITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS KINETICS; MICHAELIS CONSTANT; PROTEIN FOLDING; PROTEIN HYDROLYSIS; TEMPERATURE DEPENDENCE;

ANIMALS; CARBOXYPEPTIDASES A; CATALYSIS; CATTLE; ESTERS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; KINETICS; MODELS, CHEMICAL; PEPTIDES; PROTEIN CONFORMATION; SPECTROPHOTOMETRY, ULTRAVIOLET; TEMPERATURE; THERMODYNAMICS; TIME FACTORS; UREA;

EID: 80053575236     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.21688     Document Type: Article

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