Mast cell chymase is present in uterine cervical carcinoma and it detaches viable and growing cervical squamous carcinoma cells from substratum in vitro

Archives of Dermatological Research

Volumn 303, Issue 7, 2011, Pages 499-512

  Diaconu, Nicolae Costin ^a   Rummukainen, Jaana ^a   Naukkarinen, Anita ^a   Mättö, Mikko ^b   Harvima, Rauno J ^a   Pelkonen, Jukka ^b   Harvima, Ilkka T ^a  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Cervix carcinoma; Chymase; Mast cell; SCC; Tryptase

Indexed keywords

CHYMASE; FIBRONECTIN; PROTEINASE INHIBITOR; SQUAMOUS CELL CARCINOMA ANTIGEN; TRYPTASE;

APOPTOSIS; ARTICLE; CANCER CELL; CELL COUNT; CELL CULTURE; CELL GROWTH; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; MAST CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; STROMA; UTERINE CERVIX CARCINOMA;

ANTIGENS, NEOPLASM; APOPTOSIS; CARCINOMA; CELL ADHESION; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL SURVIVAL; CHYMASES; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINOCYTES; MAST CELLS; NEOPLASM METASTASIS; SERPINS; UTERINE CERVICAL NEOPLASMS;

EID: 80053567618     PISSN: 03403696     EISSN: 1432069X     Source Type: Journal    
DOI: 10.1007/s00403-011-1121-4     Document Type: Article

References (58)

1. Briggaman RA, Schechter NM, Fraki J, Lazarus GS (1984) Degradation of the epidermal-dermal junction by proteolytic enzymes from human skin and human polymorphonuclear leukocytes. J Exp Med 160:1027-1042 (Pubitemid 14020965)
2. Cabanillas-Saez A, Schalper JA, Nicovani SM, Rudolph MI (2002) Characterization of mast cells according to their content of tryptase and chymase in normal and neoplastic human uterine cervix. Int J Gynecol Cancer 12:92-98 (Pubitemid 34202956)
3. Campbell B, De'Ambrosis B (1990) Squamous cell carcinoma antigen in patients with cutaneous disorders. J Am Acad Dermatol 22:639-642 (Pubitemid 20134706)
4. Chin D, Boyle GM, Kane AJ et al (2005) Invasion and metastasis markers in cancers. Br J Plast Surg 58:466-474 (Pubitemid 40645385)
5. Ch'ng S, Wallis RA, Yuan L, Davis PF, Tan ST (2006) Mast cells and cutaneous malignancies. Mod Pathol 19:149-159 (Pubitemid 43250990)
6. Coussens LM, Raymond WM, Bergers G et al (1999) Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev 13:1382-1397 (Pubitemid 29270244)
7. Diaconu NC, Kaminska R, Naukkarinen A, Harvima R, Harvima I (2007) The increase in tryptase-and chymase-positive mast cells is associated with partial inactivation of chymase and increase in protease inhibitors in basal cell carcinoma. J Eur Acad Dermatol Venereol 21:908-915 (Pubitemid 47103720)
8. Diaconu NC, Kaminska R, Naukkarinen A, Harvima RJ, Nilsson G, Harvima IT (2007) Increase in CD30 ligand/CD153 and TNF-alpha expressing mast cells in basal cell carcinoma. Cancer Immunol Immunother 56:1407-1415 (Pubitemid 47024710)
9. Diaconu NC, Rummukainen J, Mättö M et al (2008) Cervical squamous carcinoma cells are resistant to the combined action of tumor necrosis factor-alpha and histamine whereas normal keratinocytes undergo cytolysis. BMC Cancer 8:46. doi: 10.1186/1471-2407-8-46 (Pubitemid 351338725)
10. Duk JM, van Voorst Vader PC, Ten Hoor KA, Hollema H, Doeglas HM, de Bruijn HW (1989) Elevated levels of squamous cell carcinoma antigen in patients with a benign disease of the skin. Cancer 64:1652-1656 (Pubitemid 19251134)
11. Duncan L, Richards L, Mihm M Jr (1998) Increased mast cell density in invasive melanoma. J Cutan Pathol 25:11-15 (Pubitemid 28059589)
12. Ebihara N, Funaki T, Murakami A, Takai S, Miyazaki M (2005) Mast cell chymase decreases the barrier function and inhibits the migration of corneal epithelial cells. Curr Eye Res 30:1061-1069 (Pubitemid 41798066)
13. Ebihara N, Takai S, Miyazaki M, Murakami A (2005) Mast cell chymase induces conjunctival epithelial cell apoptosis by a mechanism involving degradation of fibronectin. Curr Eye Res 30:429-435 (Pubitemid 40961107)
14. Goldstein SM, Leong J, Schwartz LB, Cooke D (1992) Protease composition of exocytosed human skin mast cell protease-proteoglycan complexes. Tryptase resides in a complex distinct from chymase and carboxypeptidase. J Immunol 148:2475-2482
15. Gruber BL, Marchese MJ, Suzuki K et al (1989) Synovial procollagenase activation by human mast cell tryptase dependence upon matrix metalloproteinase 3 activation. J Clin Invest 84:1657-1660
16. Harvima IT, Heikura H, Hyttinen M, Naukkarinen A (2006) Hyaluronic acid inhibits the adherence and growth of monolayer keratinocytes but does not affect the growth of keratinocyte epithelium. Arch Dermatol Res 298:207-219 (Pubitemid 44394516)
17. Harvima IT, Lappalainen K, Hirvonen M-R et al (2004) Heparin modulates the growth and adherence and augments the growthinhibitory action of TNF-α on cultured human keratinocytes. J Cell Biochem 92:372-386
18. Harvima IT, Naukkarinen A, Paukkonen K et al (1993) Mast cell tryptase and chymase in developing and mature psoriatic lesions. Arch Dermatol Res 285:184-192 (Pubitemid 23210101)
19. Harvima IT, Nilsson G, Suttle MM, Naukkarinen A (2008) Is there a role for mast cells in psoriasis? Arch Dermatol Res 300:461-478
20. Harvima IT, Schechter NM, Harvima RJ, Fraki JE (1988) Human skin tryptase: purification, partial characterization and comparison with human lung tryptase. Biochim Biophys Acta 957:71-80
21. Hsu KF, Huang SC, Shiau AL et al (2007) Increased expression level of squamous cell carcinoma antigen 2 and 1 ratio is associated with poor prognosis in early-stage uterine cervical cancer. Int J Gynecol Cancer 17:174-181
22. Huttunen M, Harvima IT (2005) Mast cell tryptase and chymase in chronic leg ulcers: chymase is potentially destructive to epithelium and is controlled by proteinase inhibitors. Br J Dermatol 152:1149-1160 (Pubitemid 40933411)
23. Iamaroon A, Pongsiriwet S, Jittidecharaks S, Pattanaporn K, Prapayasatok S, Wanachantararak S (2003) Increase of mast cells and tumor angiogenesis in oral squamous cell carcinoma. J Oral Pathol Med 32:195-199 (Pubitemid 36604013)
24. Irani AM, Bradford TR, Kepley CL, Schechter NM, Schwartz LB (1989) Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monoclonal anti/tryptase and anti-chymase antibodies. J Histochem Cytochem 37:1509-1515 (Pubitemid 19241787)
25. Iwasaki M, Nishikawa A, Akutagawa N et al (2004) E1AF/PEA3 reduces the invasiveness of SiHa cervical cancer cells by activating serine proteinase inhibitor squamous cell carcinoma antigen. Exp Cell Res 299:525-532 (Pubitemid 39179816)
26. Iwasaki M, Nishikawa A, Fujimoto T et al (2002) Anti-invasive effect of MMI-166, a new selective matrix metalloproteinase inhibitor, in cervical carcinoma cell lines. Gynecol Oncol 85:103-107 (Pubitemid 34304017)
27. Kaminska R, Helisalmi P, Harvima RJ, Naukkarinen A, Horsmanheimo M, Harvima IT (1999) Focal dermal-epidermal separation and fibronectin cleavage in basement membrane by human mast cell tryptase. J Invest Dermatol 113:567-573 (Pubitemid 29489618)
28. Kankkunen JP, Harvima IT, Naukkarinen A (1997) Quantitative analysis of tryptase and chymase containing mast cells in benign and malignant breast lesions. Int J Cancer 72:385-388 (Pubitemid 27325861)
29. Kato H (1996) Expression and function of squamous cell carcinoma antigen. Anticancer Res 16:2149-2153 (Pubitemid 26265557)
30. Kivinen PK, Kaminska R, Naukkarinen A, Harvima RJ, Horsmanheimo M, Harvima IT (2001) Release of soluble tryptase but only minor amounts of chymase activity from cutaneous mast cells. Exp Dermatol 10:246-255 (Pubitemid 32754993)
31. Kivinen PK, Nilsson G, Naukkarinen A, Harvima IT (2003) Mast cell survival and apoptosis in organ-cultured human skin. Exp Dermatol 12:53-60 (Pubitemid 36934690)
32. Lachter J, Stein M, Lichtig C, Eidelman S, Munichor M (1995) Mast cells in colorectal neoplasias and premalignant disorders. Dis Colon Rectum 38:290-293
33. Lazaar AL, Plotnick MI, Kucich U et al (2002) Mast cell chymase modifies cell-matrix interactions and inhibits mitogeninduced proliferation of human airway smooth muscle cells. J Immunol 169:1014-1020 (Pubitemid 34753461)
34. Lees M, Taylor DJ, Woolley DE (1994) Mast cell proteinases activate precursor forms of collagenase and stromelysin, but not gelatinases A and B. Eur J Biochem 223:171-177 (Pubitemid 24221660)
35. Leskinen MJ, Lindstedt KA, Wang Y, Kovanen PT (2003) Mast cell chymase induces smooth muscle cell apoptosis by a mechanism involving fibronectin degradation and disruption of focal adhesions. Arterioscler Thromb Vasc Biol 23:238-243 (Pubitemid 36231934)
36. Liotta LA, Steeg PS, Stetler-Stevenson WG (1991) Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64:327-336 (Pubitemid 121001258)
37. Liotta LA, Tryggvason K, Garbisa S, Hart I, Folts CM, Shafie S (1980) Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature 284:67-68 (Pubitemid 10098769)
38. Lohi J, Harvima I, Keski-Oja J (1992) Pericellular substrates of human mast cell tryptase: 72, 000 dalton gelatinase and fibronectin. J Cell Biochem 50:337-340
39. Murakami A, Nakagawa T, Kaneko M et al (2006) Suppression of SCC antigen promotes cancer cell invasion and migration through the decrease in E-cadherin expression. Int J Oncol 29:1231-1235
40. Murakami A, Suminami Y, Sakaguchi Y et al (2000) Specific detection and quantitation of SCC antigen 1 and SCC antigen 2 mRNAs by fluorescence-based asymmetric semi-nested reverse transcription PCR. Tumour Biol 21:224-234 (Pubitemid 30435488)
41. Nawata S, Murakami A, Torii M et al (2006) Different expression patterns of intact forms of squamous cell carcinoma antigens between normal and malignant cervical squamous epithelial tissues: nondenaturing polyacrylamide gel electrophoretic analysis. Oncol Rep 16:399-404
42. Nienartowicz A, Sobaniec-Lotowska ME, Jarocka-Cyrta E, Lemancewicz D (2006) Mast cells in neoangiogenesis. Med Sci Monit 12:53-56
43. Nishikawa A, Iwasaki M, Akutagawa N et al (2000) Expression of various matrix proteases and Ets family transcriptional factors in ovarian cancer cell lines: correlation to invasive potential. Gynecol Oncol 79:256-263
44. Nyberg P, Ylipalosaari M, Sorsa T, Salo T (2006) Trypsins and their role in carcinoma growth. Exp Cell Res 312:1219-1228
45. Okumura K, Takai S, Muramatsu M et al (2004) Human chymase degrades human fibronectin. Clin Chim Acta 347:223-225
46. Otto FJ (1994) High-resolution analysis of nuclear DNA employing the fluorochrome DAPI. Methods Cell Biol 41:211-217
47. Pereira PJ, Bergner A, Macedo-Ribeiro S et al (1998) Human beta-tryptase is a ring-like tetramer with active sites facing a central pore. Nature 392:306-311 (Pubitemid 28155107)
48. Ribatti D, Ennas M, Vacca A et al (2003) Tumor vascularity and tryptase-positive mast cells correlate with a poor prognosis in melanoma. Eur J Clin Invest 33:420-425 (Pubitemid 36583711)
49. Saarinen J, Kalkkinen N, Welgus HG, Kovanen PT (1994) Activation of human interstitial procollagenase through direct cleavage of the leu83-thr84 bond by mast cell chymase. J Biol Chem 269:18134-18140
50. Schick C, Kamachi Y, Bartuski AJ et al (1997) Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase. J Biol Chem 272:1849-1855 (Pubitemid 27045716)
51. Stack MS, Johnson DA (1994) Human mast cell tryptase activates single-chain urinary type plasminogen activator (pro-urokinase). J Biol Chem 269:9416-9419 (Pubitemid 24196529)
52. Stenman J, Hedström J, Grénman R, Leivo I, Finne P, Palotie A, Orpana A (2001) Relative levels of SCCA2 and SCCA1 mRNA in primary tumors predicts recurrent disease in squamous cell cancer of the head and neck. Int J Cancer 95:39-43
53. Stetler-Stevenson WG, Aznavoorian S, Liotta LA (1993) Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol 9:541-573
54. Takanami I, Takeuchi K, Naruke M (2000) Mast cell density is associated with angiogenesis and poor prognosis in pulmonary adenocarcinoma. Cancer 88:2686-2692 (Pubitemid 30417928)
55. Tiltman AJ (2005) The pathology of cervical tumours. Best Pract Res Clin Obstet Gynaecol 19:485-500 (Pubitemid 41263801)
56. Weidner N, Austen KF (1993) Heterogeneity of mast cells at multiple body sites. Fluorescent determination of avidin binding and immunofluorescent determination of chymase, tryptase, and carboxypeptidase content. Pathol Res Pract 189:156-162 (Pubitemid 23123621)
57. Wolf K, Friedl P (2006) Molecular mechanisms of cancer cell invasion and plasticity. Br J Dermatol 154:11-15
58. Yoshii M, Jikuhara A, Mori S et al (2005) Mast cell tryptase stimulates DLD-1 carcinoma through prostaglandin-and MAP kinase-dependent manners. J Pharmacol Sci 98:450-458 (Pubitemid 41297020)