Release of soluble tryptase but only minor amounts of chymase activity from cutaneous mast cells

Experimental Dermatology

Volumn 10, Issue 4, 2001, Pages 246-255

  Kivinen, P K ^a   Kaminska, R ^a   Naukkarinen, A ^a   Harvima, R J ^a   Horsmanheimo, M ^a   Harvima, Ilkka T ^a  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Mediator release; Protease; Protease inhibitor; Skin blister; Skin culture

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; CHYMASE; COMPOUND 48-80; HISTAMINE; LIQUID NITROGEN; SERINE PROTEINASE; TRYPTASE;

ADULT; ARTICLE; BLISTER; CELL COUNT; CONCENTRATION RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; FEMALE; FREEZING; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNOREACTIVITY; INHIBITION KINETICS; MALE; MAST CELL DEGRANULATION; NORMAL HUMAN; SKIN CELL; SKIN CULTURE; SOLUBILIZATION; SUPERNATANT; THAWING; ULTRASOUND;

ADULT; ALPHA 1-ANTICHYMOTRYPSIN; BLISTER; CHYMASES; ENZYME INHIBITORS; FEMALE; FREEZING; HISTAMINE RELEASE; HISTOCYTOCHEMISTRY; HUMANS; MALE; MAST CELLS; MIDDLE AGED; ORGAN CULTURE TECHNIQUES; P-METHOXY-N-METHYLPHENETHYLAMINE; SERINE ENDOPEPTIDASES; SKIN; SOLUBILITY; TISSUE EXTRACTS; TRYPTASES;

EID: 0034874296     PISSN: 09066705     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0625.2001.100404.x     Document Type: Article

References (38)

1. Mast cell proteinases and cytokines in skin inflammation
2. Degradation of the epidermal-dermal junction by proteolytic enzymes from human skin and human polymorphonuclear leukocytes
3. 84 bond by mast cell chymase
4. Rapid and specific conversion of precursor interleukin 1β (IL-1β) to an active IL-1 species by human mast cell chymase
5. Cleavage of type I procollagen by human mast cell chymase initiates collagen fibril formation and generates a unique carboxyl-terminal propeptide
6. Human mast cell chymase and leukocyte elastase release latent transforming growth factor-β1 from the extracellular matrix of cultured human epithelial and endothelial cells
7. Protease composition of exocytosed human skin mast cell protease-proteoglycan complexesl: Tryptase resides in a complex distinct from chymase and carboxypeptidase
8. Reaction of human skin chymotrypsin-like proteinase chymase with plasma proteinase inhibitors
9. Highly efficient inhibition of human chymase by α(2)-macroglobulin
10. Identification of SLPI (secretory leukocyte protease inhibitor) in human mast cells using immunohistochemistry and in situ hybridisation
11. Alterations in mast cell proteinases and protease inhibitors in the progress of cutaneous herpes zoster infection
12. Decreased chymase activity is associated with increased levels of protease inhibitors in mast cells of psoriatic lesions
13. Synovial pro-collagenase activation by human mast cell tryptase. Dependence upon matrix metalloproteinase 3 activation
14. Pericellular substrates of human mast cell tryptase: 72,000 dalton gelatinase and fibronectin
15. Focal dermal-epidermal separation and fibronectin cleavage in basement membrane by human mast cell tryptase
16. Human mast cell tryptase activates single-chain urinary-type plasminogen activator (prourokinase)
17. Mast cell tryptase stimulates both human dermal fibroblast proliferation and type I collagen production
18. Human mast cells stimulate vascular tube formation: Tryptase is a novel, potent angiogenic factor
19. Skin tryptase: Features and expression in human dermatological disorders
20. Mast cell chymase and tryptase during tissue turnover: Analysis on in vitro mitogenesis of fibroblasts and keratinocytes and alterations in cutaneous scars
21. Alterations in mast cells showing tryptase and chymase activity in epithelializating and chronic wounds
22. The release of histamine is associated with the inactivation of mast cell chymase during immediate allergic wheal reaction in the skin
23. Suction blister formation in skin after acute and repeated mast cell degranulation
24. Human skin proteases: Separation and characterization of two alkaline proteases, one splitting trypsin and the other chymotrypsin substrates
25. Biochemical and histochemical evaluation of tryptase in various human tissues
26. Human skin tryptase: Purification, partial characterization and comparison with human lung tryptase
27. Mast cells of psoriatic and atopic dermatitis skin are positive for TNF-α and their degranulation is associated with expression of ICAM-1 in the epidermis
28. Optimization of histamine radio enzyme assay with purified histamine-N-methyltransferase
29. Quantitative digital image analysis applied to demonstrate the stratified distribution of involucrin in organ cultured human skin
30. Identification and characterization of multiple forms of tryptase from human mast cells
31. The potential clinical utility of serum α-protryptase levels
32. Release of tryptase together with histamine during the immediate cutaneous response to allergen
33. Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis
34. Two distinct forms of human mast cell chymase: Differences in affinity for heparin and in distribution in skin, heart, and other tissues
35. Serine proteinases are regionally segregated within mast cell granules
36. Regulation of the activity of human chymase during storage and release from mast cells: The contribution of inorganic cations, pH, heparin and histamine
37. Inhibitors of chymase as mast cell-stabilizing agents: Contribution of chymase in the activation of human mast cells
38. Chymase cleavage of stem cell factor yields a bioactive, soluble product