In silico-based structural analysis of arylthiophene derivatives for FTase inhibitory activity, hERG, and other toxic effects

Journal of Biomolecular Screening

Volumn 16, Issue 9, 2011, Pages 1037-1046

  Narayana Moorthy, N S Hari ^a   Sousa, Sergio F ^a   Ramos, Maria J ^a   Fernandes, Pedro A ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

arylthiophene; farnesyltransferase inhibitors; hERG; QSAR; toxicity

Indexed keywords

ARYLTHIOPHENE DERIVATIVE; POTASSIUM CHANNEL HERG; PROTEIN FARNESYLTRANSFERASE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER MODEL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULE; PHARMACOPHORE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SURFACE PROPERTY; TOXICITY; VALIDATION PROCESS;

ENZYME INHIBITORS; ETHER-A-GO-GO POTASSIUM CHANNELS; FARNESYLTRANSTRANSFERASE; LETHAL DOSE 50; MODELS, STATISTICAL; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REPRODUCIBILITY OF RESULTS; THIOPHENES;

EID: 80053498208     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057111414899     Document Type: Article

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