The fractions of respiratory tract cells at risk in formaldehyde carcinogenesis

Inhalation Toxicology

Volumn 23, Issue 12, 2011, Pages 689-706

  Miller, Frederick J ^a   Kimbell, Julia S ^b   Preston, R Julian ^c   Overton, John H ^d   Gross, Elizabeth A ^e   Conolly, Rory B ^c  

^a Fred J Miller and Associates LLC   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d A305 the Homestead   (United States)

^e HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

Author keywords

Carcinogenesis; Formaldehyde; Humans; Rats; Respiratory tract cells; Risk

Indexed keywords

FORMALDEHYDE;

ARTICLE; BASAL CELL; BRONCHUS MUCOSA; CANCER RISK; CELL COUNT; CELL CYCLE; CELL DIVISION; CELL FRACTIONATION; CHEMICAL CARCINOGENESIS; CIGARETTE SMOKING; CILIATED EPITHELIUM; EPITHELIUM CELL; HIGH RISK POPULATION; HUMAN; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; LUNG CARCINOGENESIS; NONHUMAN; NOSE MUCOSA; OLFACTORY EPITHELIUM; PREDICTIVE VALUE; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; RISK ASSESSMENT; SENSITIVITY ANALYSIS; SQUAMOUS EPITHELIUM; STATISTICAL MODEL; STEM CELL; TRACHEA MUCOSA;

ANIMALS; BIOLOGICAL ASSAY; CARCINOGENS; CELL PROLIFERATION; CELLS, CULTURED; EPITHELIAL CELLS; FORMALDEHYDE; HUMANS; MODELS, BIOLOGICAL; RATS; RESPIRATORY MUCOSA; SMOKING;

RATTUS;

EID: 80053464323     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2011.603190     Document Type: Article

References (70)

1. Boren HG, Paradise LJ. 1978. Cytokinetics of lung. In Pathogenesis and therapy of lung cancer, ed. C. C., Harris, Marcel Dekker, New York; pp. 369-418.
2. Borum P. 1992. Functional anatomy and physiology of the nose. Ear Nose Throat J 71:8-10.
3. Chemical Industry Institute of Toxicology (CIIT). 1999. Formaldehyde hazard characterization and dose-response assessment for carcinogenicity by the route of inhalation. Chemical Industry Institute of Toxicology, 1999 [published report].
4. Conolly RB, Kimbell JS, Janszen D, Schlosser PM, Kalisak D, Preston J, Miller FJ. 2003. Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat. Toxicol Sci 75:432-447. (Pubitemid 37220290)
5. Conolly RB, Kimbell JS, Janszen D, Schlosser PM, Kalisak D, Preston J, Miller FJ. 2004. Human respiratory tract cancer risks of inhaled formaldehyde: dose-response predictions derived from biologically-motivated computational modeling of a combined rodent and human dataset. Toxicol Sci 82:279-296. (Pubitemid 39485341)
6. Crapo JD, Chang YL, Miller FJ, Mercer RR. 1990. Aspects of respiratory tract structure and function important for dosimetry modeling: interspecies comparisons. In Principles of route-to-route extrapolation for risk assessment, eds. J. R., Gerrity and C. J., Henry, Elsevier, New York; pp. 15-32.
7. Crump KS, Chen C, Fox JF, Van Landingham C, Subramaniam R. 2008. Sensitivity analysis of biologically motivated model for formaldehyde-induced respiratory cancer in humans. Ann Occup Hyg 52:481-495.
8. DeSesso JM. 1993. The relevance to humans of animal models for inhalation studies of cancer in the nose and upper airways. Qual Assur 2:213-231.
9. Evans MJ, Shami SG. 1989. Lung cell kinetics. In Lung cell biology, ed. D., Massaro, Marcel Dekker, New York; pp. 1-36.
10. Evans MJ, Cabral LJ, Stephens RJ, Freeman G. 1973. Renewal of alveolar epithelium in the rat following exposure to NO2. Am J Pathol 70:175-198.
11. Evans MJ, Cabral LJ, Stephens RJ, Freeman G. 1975. Transformation of alveolar type 2 cells to type 1 cells following exposure to NO2. Exp Mol Pathol 22:142-150.
12. Evans MJ, Shami SG, Cabral-Anderson LJ, Dekker NP. 1986. Role of nonciliated cells in renewal of the bronchial epithelium of rats exposed to NO2. Am J Pathol 123:126-133. (Pubitemid 16038141)
13. Feron VJ, Arts JHE, Kuper CF, Slootweg PJ, Woutersen RA. 2001. Health risks associated with inhaled nasal toxicants. Crit Rev Toxicol 31:313-347. (Pubitemid 32565570)
14. Getchell TV, Doty RL, Bartoshuk LM, Snow JBJ. 1991. Smell and taste in health and disease. New York: Raven Press.
15. Gross EA, Morgan KT. 1992. Architecture of nasal passages and larynx. In Comparative biology of the normal lung, ed. R. A., Parent, CRC Press, Boca Raton, FL; pp. 7-25.
16. Gross EA, Starr TB, Randall HW, Morgan KT. 1987. Morphometric analysis of the primate nasal cavity. The Toxicologist 7:193.
17. Harkema J.R. 1991. Comparative aspects of nasal airway anatomy: relevance to inhalation toxicology. Toxicol Pathol 19:321-336.
18. Harkema JR. 1999. Comparative structure, function, and toxicity of nasal airways: predicting human effects from animal studies. In Toxicology of the Lung, 3rd ed., eds. D. E., Gardner, J. D., Crapo and R. O., McClellan, Taylor and Francis, Philadelphia; pp. 55-83.
19. Harkema JR, Morgan KT. 1996. Normal morphology of the nasal passages in laboratory rodents. In Monographs on pathology of laboratory animals, respiratory system, eds. T. C., Jones, D. L., Dungworth and U., Mohr, Springer-Verlag, New York, pp. 3-17.
20. Harkema JR, Plopper CG, Hyde DM, Wilson DW, St George JA, Wong VJ. 1987. Nonolfactory surface epithelium of the nasal cavity of the bonnet monkey: a morphologic and morphometric study of the transitional and respiratory epithelium. Am J Anat 180:266-279. (Pubitemid 17161664)
21. Hebel R, Stromberg MW. 1986. Anatomy and embryology of the laboratory rat. Baltimore: The Williams and Wilkins Company.
22. Heck HD, Casanova M, Starr TB. 1990. Formaldehyde toxicity-new understanding. Crit Rev Toxicol 20:397-426.
23. Hotchkiss JA, Harkema JR, Johnson NF. 1997. Kinetics of nasal epithelial cell loss and proliferation in F344 rats following a single exposure to 0.5 ppm ozone. Toxicol Appl Pharmacol 143:75-82. (Pubitemid 27130609)
24. Kaufman SL. 1980. Cell proliferation in the mammalian lung. Int Rev Exp Pathol 22:131-191.
25. Kepler GM, Richardson RB, Morgan KT, Kimbell JS. 1998. Computer simulation of inspiratory nasal airflow and inhaled gas uptake in a rhesus monkey. Toxicol Appl Pharmacol 150:1-11. (Pubitemid 28288413)
26. Kerns WD, Pavkov KL, Donofrio DJ, Gralla EJ, Swenberg JA. 1983. Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure. Cancer Res 43:4382-4392. (Pubitemid 13041877)
27. Keyhani K, Scherer PW, Mozell MM. 1995. Numerical simulation of airflow in the human nasal cavity. J Biomech Eng 117:429-441.
28. Kimbell JS, Godo MN, Gross EA, Joyner DR, Richardson RB, Morgan KT. 1997. Computer simulation of inspiratory airflow in all regions of the F344 rat nasal passages. Toxicol Appl Pharmacol 145:388-398. (Pubitemid 27346529)
29. Kimbell JS, Overton JH, Subramaniam RP, Schlosser PM, Morgan KT, Conolly RB, Miller FJ. 2001. Dosimetry modeling of inhaled formaldehyde: binning nasal flux predictions for quantitative risk assessment. Toxicol Sci 64:111-121. (Pubitemid 33062193)
30. Liteplo RG, Meek ME. 2003. Inhaled formaldehyde: exposure estimation, hazard characterization, and exposure-response analysis. J Toxicol Environ Health B Crit Rev 6:85-114. (Pubitemid 36020999)
31. Liu JY, Nettesheim P, Randell SH. 1994. Growth and differentiation of tracheal epithelial progenitor cells. Am J Physiol 266:L296-L307.
32. Mariassy AT. 1992. Epithelial cells of trachea and bronchi. In Comparative biology of the normal lung, Vol. 1, ed. R. A., Parent, CRC Press, Boca Raton; pp. 63-76.
33. Mercer RR, Laco JM, Crapo JD. 1987. Three-dimensional reconstruction of alveoli in the rat lung for pressure-volume relationships. J Appl Physiol 62:1480-1487. (Pubitemid 17070430)
34. Mercer RR, Russell ML, Roggli VL, Crapo JD. 1994. Cell number and distribution in human and rat airways. Am J Respir Cell Mol Biol 10:613-624.
35. Méry S, Gross EA, Joyner DR, Godo M, Morgan KT. 1994. Nasal diagrams: a tool for recording the distribution of nasal lesions in rats and mice. Toxicol Pathol 22:353-372. (Pubitemid 24314247)
36. Miller FJ, Graham JA, Gardner DE. 1983. The changing role of animal toxicology in support of regulatory decisions. Environ Health Perspect 52:169-176. (Pubitemid 14177101)
37. Monticello TM. 1990. Formaldehyde-induced pathology and cell proliferation. Ph.D. diss., Duke University, Durham, NC.
38. Monticello TM, Morgan KT, Hurtt ME. 1990. Unit length as the denominator for quantitation of cell proliferation in nasal epithelia. Toxicol Pathol 18:24-31. (Pubitemid 20191995)
39. Moolgavkar SH, Luebeck EG. 1992. Interpretation of labeling indices in the presence of cell death. Carcinogenesis 13:1007-1010.
40. Morgan KT. 1997. A brief review of formaldehyde carcinogenesis in relation to rat nasal pathology and human health risk assessment. Toxicol Pathol 25:291-307. (Pubitemid 27280292)
41. Morgan KT, Jiang XZ, Patterson DL, Gross EA. 1984. The nasal mucociliary apparatus. Correlation of structure and function in the rat. Am Rev Respir Dis 130:275-281. (Pubitemid 14055817)
42. Morgan KT, Kimbell JS, Monticello TM, Patra AL, Fleishman A. 1991. Studies of inspiratory airflow patterns in the nasal passages of the F344 rat and rhesus monkey using nasal molds: relevance to formaldehyde toxicity. Toxicol Appl Pharmacol 110:223-240.
43. Overton JH, Kimbell JS, Miller FJ. 2001. Dosimetry modeling of inhaled formaldehyde: the human respiratory tract. Toxicol Sci 64:122-134. (Pubitemid 33062194)
44. Phipps RJ. 1981. The airway mucociliary system. Int Rev Physiol 23:213-260.
45. Pinkerton KE, Gehr P, Crapo JD. 1992. Architecture and cellular composition of the air-blood barrier. In Comparative biology of the normal lung, Vol. 1, ed. R. A., Parent, CRC Press, Boca Raton; pp. 121-128.
46. Plopper CG, Heidsiek JG, Weir AJ, George JA, Hyde DM. 1989. Tracheobronchial epithelium in the adult rhesus monkey: a quantitative histochemical and ultrastructural study. Am J Anat 184:31-40. (Pubitemid 19039137)
47. Proctor DF. 1982. The mucociliary system. In The nose, upper airway physiology and the atmospheric environment, eds. D. F., Proctor,and I., Andersen, Elsevier Biomedical Press, New York; pp. 245-278.
48. Proctor DF, Andersen I. 1976. Nasal mucociliary function in normal man. Rhinology 14:11-17.
49. Proctor DF, Andersen I, eds. 1982. The nose, upper airway physiology and the atmospheric environment. New York: Elsevier Biomedical Press.
50. Proctor DF, Chang JCF. 1983. Comparative anatomy and physiology of the nasal cavity. In Nasal tumors in animals and man, eds. G., Reznik S. F. Stinson, CRC Press, Boca Raton, pp. 1-33.
51. Randall HW, Monticello TM, Morgan KT. 1988. Large area sectioning for morphologic studies of nonhuman primate nasal cavities. Stain Technol 63:355-362. (Pubitemid 19094119)
52. Randell SH, Comment CE, Ramaekers FC, Nettesheim P. 1991. Properties of rat tracheal epithelial cells separated based on expression of cell surface alpha-galactosyl end groups. Am J Respir Cell Mol Biol 4:544-554.
53. St., George JA, Harkema JR, Hyde DM, Plopper CG. 1993. Cell populations and structure/function relationships of cells in the airways. In Toxicology of the Lung, 2nd ed., eds. D. E., Gardner, J. D., Crapo and R.O., McClellan, Raven Press, Ltd., New York; pp. 81-110.
54. Sarangapani R, Teeguarden JG, Cruzan G, Clewell HJ, Andersen ME. 2002. Physiologically based pharmacokinetic modeling of styrene and styrene oxide respiratory-tract dosimetry in rodents and humans. Inhal Toxicol 14:789-834.
55. Schreider JP. 1986. Comparative anatomy and function of the nasal passages. In Toxicology of the nasal passages, ed. C. S., Barrow, Hemisphere, New York; pp. 1-25.
56. Sills RC, Morgan KT, Boorman GA. 1994. Accessory nasal structures in toxicology studies. Inhal Toxicol 6:221-248.
57. Stone KC, Mercer RR, Gehr P, Stockstill B, Crapo JD. 1992. Allometric relationships of cell numbers and size in the mammalian lung. Am J Respir Cell Mol Biol 6:235-243.
58. Subramaniam RP, Richardson RB, Morgan KT, Guilmette RA, Kimbell JS. 1998. Computational fluid dynamics simulations of inspiratory airflow in the human nose and nasopharynx. Inhal Toxicol 10:92-120.
59. Subramaniam RP, Crump KS, Van Landingham C, White P, Chen C, Schlosser PM. 2007. Uncertainties in the CIIT model for formaldehyde-induced carcinogenicity in the rat: a limited sensitivity analysis-I. Risk Anal 27:1237-1254. (Pubitemid 350222038)
60. Subramaniam RP, Chen C, Crump KS, Devoney D, Fox JF, Portier CJ, Schlosser PM, Thompson CM, White P. 2008. Uncertainties in biologically-based modeling of formaldehyde-induced respiratory cancer risk: identification of key issues. Risk Anal 28:907-923.
61. Takezawa J, Miller FJ, ÖNeil JJ. 1980. Single-breath diffusing capacity and lung volumes in small laboratory mammals. J Appl Physiol 48:1052-1059. (Pubitemid 10059477)
62. U. S. Environmental Protection Agency (U. S. EPA). 1987. Assessment of Health Risks to Garment Workers and Certain Home Residents from Exposure to Formaldehyde. Office of Pesticides and Toxic Substances, Washington, DC.
63. U. S. Environmental Protection Agency (U. S. EPA). 1991. Formaldehyde Risk Assessment Update-Final Draft. Office of Toxic Substances, Washington, DC.
64. U. S. Environmental Protection Agency (U. S. EPA). 1996. Air Quality Criteria for Ozone and Related Photochemical Oxicants. Office of Research and Development, Washington, D.C. EPA600/ P-93/004cF.
65. U. S. Environmental Protection Agency (U. S. EPA). 2005. Guidelines for Carcinogen Risk Assessment. Risk Assessment Forum. Washington, DC. EPA/630/P-03/001F.
66. Uraih LC, Maronpot RR. 1990. Normal histology of the nasal cavity and application of special techniques. Environ Health Perspect 85:187-208. (Pubitemid 20315299)
67. Weibel ER. 1963. Morphometry of the human lung. New York: Academic Press, Inc.
68. Wolf DC, Morgan KT, Gross EA, Barrow C, Moss OR, James RA, Popp JA. 1995. Two-year inhalation exposure of female and male B6C3F1 mice and F344 rats to chlorine gas induces lesions confined to the nose. Fundam Appl Toxicol 24:111-131.
69. Yeh H-C., Harkema JR. 1993. Gross morphometry of airways. In: Gardner, D. E., Crapo, J. D., and McClellan, R. O., eds. Toxicology of the Lung. 2nd ed. New York, Raven Press, New York, pp. 55-79.
70. Yeh HC, Schum GM, Duggan MT. 1979. Anatomic models of the tracheobronchial and pulmonary regions of the rat. Anat Rec 195:483-492. (Pubitemid 10210902)