메뉴 건너뛰기




Volumn 52, Issue 6, 2008, Pages 481-495

Sensitivity analysis of biologically motivated model for formaldehyde-induced respiratory cancer in humans

Author keywords

Formaldehyde; Nasal cancer; Quantitative risk assessment; Respiratory cancer; Sensitivity analysis; Two stage clonal expansion model

Indexed keywords

CONCURRENCY CONTROL; CONTROL THEORY; ESTIMATION; FORMALDEHYDE; HEALTH; MODAL ANALYSIS; RATS; RISK ASSESSMENT; RISK PERCEPTION; ROBUST CONTROL; ROBUSTNESS (CONTROL SYSTEMS); STANDARDS;

EID: 49449098781     PISSN: 00034878     EISSN: 14753162     Source Type: Journal    
DOI: 10.1093/annhyg/men038     Document Type: Article
Times cited : (18)

References (46)
  • 1
    • 49449085090 scopus 로고    scopus 로고
    • BfR, Federal Institute of Risk Assessment, Germany. (2006) Toxicological assessment of formaldehyde. Opinion of BfR No. 023/2006. Available at http://www.bfr.bund.de/cm/290/toxicological_assessment_of_formaldehyde.pdf. Accessed 19 June 2008.
    • BfR, Federal Institute of Risk Assessment, Germany. (2006) Toxicological assessment of formaldehyde. Opinion of BfR No. 023/2006. Available at http://www.bfr.bund.de/cm/290/toxicological_assessment_of_formaldehyde.pdf. Accessed 19 June 2008.
  • 2
    • 0025823449 scopus 로고
    • Covalent binding of inhaled formaldehyde to DNA in the respiratory tract of rhesus monkeys: Pharmacokinetics, rat-to-monkey interspecies scaling, and extrapolation to man
    • Casanova M, Morgan KT, Steinhagen WH et al. (1991) Covalent binding of inhaled formaldehyde to DNA in the respiratory tract of rhesus monkeys: pharmacokinetics, rat-to-monkey interspecies scaling, and extrapolation to man. Fundam Appl Toxicol; 17: 409-28.
    • (1991) Fundam Appl Toxicol , vol.17 , pp. 409-428
    • Casanova, M.1    Morgan, K.T.2    Steinhagen, W.H.3
  • 3
    • 77957183484 scopus 로고
    • DNA-protein cross-links and cell replication at specific sites in the nose of F344 rats exposed subchronically to formaldehyde
    • Casanova M, Morgan KT, Gross EA et al. (1994) DNA-protein cross-links and cell replication at specific sites in the nose of F344 rats exposed subchronically to formaldehyde. Fundam Appl Toxicol; 23: 525-36.
    • (1994) Fundam Appl Toxicol , vol.23 , pp. 525-536
    • Casanova, M.1    Morgan, K.T.2    Gross, E.A.3
  • 4
    • 0033670964 scopus 로고    scopus 로고
    • Simulation modeling of the tissue disposition of formaldehyde to predict nasal DNA-protein cross-links in F344 rats, rhesus monkeys, and humans
    • Conolly RB, Lilly PD, Kimbell JS. (2000) Simulation modeling of the tissue disposition of formaldehyde to predict nasal DNA-protein cross-links in F344 rats, rhesus monkeys, and humans. Environ Health Perspect; 108 (Suppl 5): 919-24.
    • (2000) Environ Health Perspect , vol.108 , Issue.SUPPL. 5 , pp. 919-924
    • Conolly, R.B.1    Lilly, P.D.2    Kimbell, J.S.3
  • 5
    • 0036176499 scopus 로고    scopus 로고
    • Dose response for formaldehyde-induced cytotoxicity in the human respiratory tract
    • Conolly RB, Kimbell JS, Janszen DB et al. (2002) Dose response for formaldehyde-induced cytotoxicity in the human respiratory tract. Regul Toxicol Pharmacol; 35: 32-43.
    • (2002) Regul Toxicol Pharmacol , vol.35 , pp. 32-43
    • Conolly, R.B.1    Kimbell, J.S.2    Janszen, D.B.3
  • 6
    • 0141618447 scopus 로고    scopus 로고
    • Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat
    • Conolly RB, Kimbell JS, Janszen D et al. (2003) Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat. Toxicol Sci; 75: 432-47.
    • (2003) Toxicol Sci , vol.75 , pp. 432-447
    • Conolly, R.B.1    Kimbell, J.S.2    Janszen, D.3
  • 7
    • 8444227400 scopus 로고    scopus 로고
    • Human respiratory tract cancer risks of inhaled formaldehyde: Dose-response predictions derived from biologically motivated computational modeling of a combined rodent and human dataset
    • Conolly RB, Kimbell JS, Janszen D et al. (2004) Human respiratory tract cancer risks of inhaled formaldehyde: dose-response predictions derived from biologically motivated computational modeling of a combined rodent and human dataset. Toxicol Sci; 82: 279-96.
    • (2004) Toxicol Sci , vol.82 , pp. 279-296
    • Conolly, R.B.1    Kimbell, J.S.2    Janszen, D.3
  • 8
    • 0028696112 scopus 로고
    • Limitations of biological models of carcinogenesis for low-dose extrapolation
    • Crump KS. (1994a) Limitations of biological models of carcinogenesis for low-dose extrapolation. Risk Anal; 14: 883-6.
    • (1994) Risk Anal , vol.14 , pp. 883-886
    • Crump, K.S.1
  • 9
    • 0028557190 scopus 로고
    • Use of mechanistic models to estimate low dose cancer risks
    • Crump KS. (1994b) Use of mechanistic models to estimate low dose cancer risks. Risk Anal; 14: 1033-8.
    • (1994) Risk Anal , vol.14 , pp. 1033-1038
    • Crump, K.S.1
  • 10
    • 0018176934 scopus 로고
    • Cigarettesmoking and bronchial carcinoma: Dose and time relationships among regular smokers and lifelong nonsmokers
    • Doll R, Peto R. (1978) Cigarettesmoking and bronchial carcinoma: dose and time relationships among regular smokers and lifelong nonsmokers. J Epidemiol Community Health; 32: 303-13.
    • (1978) J Epidemiol Community Health , vol.32 , pp. 303-313
    • Doll, R.1    Peto, R.2
  • 11
    • 0030130984 scopus 로고    scopus 로고
    • Risk assessment of nongenotoxic carcinogens based upon cell proliferation/death rates in rodents
    • Gaylor DW, Zheng Q. (1996) Risk assessment of nongenotoxic carcinogens based upon cell proliferation/death rates in rodents. Risk Anal; 16: 221-5.
    • (1996) Risk Anal , vol.16 , pp. 221-225
    • Gaylor, D.W.1    Zheng, Q.2
  • 12
    • 1642504760 scopus 로고    scopus 로고
    • Statistical analysis of non-monotonic dose-response relationships: Research design and analysis of nasal cell proliferation in rats exposed to formaldehyde
    • Gaylor DW, Lutz WK, Conolly RB. (2004) Statistical analysis of non-monotonic dose-response relationships: research design and analysis of nasal cell proliferation in rats exposed to formaldehyde. Toxicol Sci; 77: 158-64.
    • (2004) Toxicol Sci , vol.77 , pp. 158-164
    • Gaylor, D.W.1    Lutz, W.K.2    Conolly, R.B.3
  • 13
    • 0021988861 scopus 로고
    • Genotoxicity of formaldehyde in cultured human bronchial fibroblasts
    • Grafstrom RC, Curren RD, Yang LL et al. (1985) Genotoxicity of formaldehyde in cultured human bronchial fibroblasts. Science; 228: 89-91.
    • (1985) Science , vol.228 , pp. 89-91
    • Grafstrom, R.C.1    Curren, R.D.2    Yang, L.L.3
  • 14
    • 0030915471 scopus 로고    scopus 로고
    • Inherent increase of apoptosis in liver tumors: Implications for carcinogenesis and tumor regression
    • Grasl-Kraupp B, Ruttkay-Nedecky B, Müllauer L et al. (1997) Inherent increase of apoptosis in liver tumors: implications for carcinogenesis and tumor regression. Hepatology; 25: 906-11.
    • (1997) Hepatology , vol.25 , pp. 906-911
    • Grasl-Kraupp, B.1    Ruttkay-Nedecky, B.2    Müllauer, L.3
  • 15
    • 0033939534 scopus 로고    scopus 로고
    • Quantitative analysis of tumor initiation in rat liver: Role of cell replication and cell death (apoptosis)
    • Grasl-Kraupp B, Luebeck G, Wagner A et al. (2000) Quantitative analysis of tumor initiation in rat liver: role of cell replication and cell death (apoptosis). Carcinogenesis; 21: 1411-21.
    • (2000) Carcinogenesis , vol.21 , pp. 1411-1421
    • Grasl-Kraupp, B.1    Luebeck, G.2    Wagner, A.3
  • 16
    • 0026556048 scopus 로고
    • Value of historical controls in the interpretation of rodent tumor data
    • Haseman JK. (1992) Value of historical controls in the interpretation of rodent tumor data. Drug Inf J; 26: 191-200.
    • (1992) Drug Inf J , vol.26 , pp. 191-200
    • Haseman, J.K.1
  • 18
    • 0033214356 scopus 로고    scopus 로고
    • Pharmacodynamics of formaldehyde: Applications of a model for the arrest of DNA replication by DNA-protein cross-links
    • Heck H, Casanova M. (1999) Pharmacodynamics of formaldehyde: applications of a model for the arrest of DNA replication by DNA-protein cross-links. Toxicol Appl Pharmacol; 160: 86-100.
    • (1999) Toxicol Appl Pharmacol , vol.160 , pp. 86-100
    • Heck, H.1    Casanova, M.2
  • 19
    • 0025288510 scopus 로고
    • Formaldehyde toxicity - new understanding
    • Heck H, Casanova M, Starr T. (1990) Formaldehyde toxicity - new understanding. Crit Rev Toxicol; 20: 397-420.
    • (1990) Crit Rev Toxicol , vol.20 , pp. 397-420
    • Heck, H.1    Casanova, M.2    Starr, T.3
  • 20
    • 0035216232 scopus 로고    scopus 로고
    • Functional polymorphism in the alcohol dehydrogenase 3 (ADH3) promoter
    • Hedberg JJ, Backlund M, Stromberg P et al. (2001) Functional polymorphism in the alcohol dehydrogenase 3 (ADH3) promoter. Pharmacogenetics; 11: 815-24.
    • (2001) Pharmacogenetics , vol.11 , pp. 815-824
    • Hedberg, J.J.1    Backlund, M.2    Stromberg, P.3
  • 21
    • 0344643073 scopus 로고    scopus 로고
    • Formaldehyde-induced gene expression in F344 rat nasal respiratory epithelium
    • Hester SD, Benavides GB, Yoon L et al. (2003) Formaldehyde-induced gene expression in F344 rat nasal respiratory epithelium. Toxicology; 187: 13-24.
    • (2003) Toxicology , vol.187 , pp. 13-24
    • Hester, S.D.1    Benavides, G.B.2    Yoon, L.3
  • 22
    • 0020602028 scopus 로고
    • Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure
    • Kerns W, Pavkov K, Donofrio D et al. (1983) Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure. Cancer Res; 43: 4382-92.
    • (1983) Cancer Res , vol.43 , pp. 4382-4392
    • Kerns, W.1    Pavkov, K.2    Donofrio, D.3
  • 23
    • 0035158910 scopus 로고    scopus 로고
    • Dosimetry modeling of inhaled formaldehyde: Binning nasal flux predictions for quantitative risk assessment
    • Kimbell JS, Overton JH, Subramaniam RP et al. (2001a) Dosimetry modeling of inhaled formaldehyde: binning nasal flux predictions for quantitative risk assessment. Toxicol Sci; 64: 111-21.
    • (2001) Toxicol Sci , vol.64 , pp. 111-121
    • Kimbell, J.S.1    Overton, J.H.2    Subramaniam, R.P.3
  • 24
    • 0035172387 scopus 로고    scopus 로고
    • Dosimetry modeling of inhaled formaldehyde: Comparisons of local flux predictions in the rat, monkey, and human nasal passages
    • Kimbell JS, Subramaniam RP, Gross EA et al. (2001b) Dosimetry modeling of inhaled formaldehyde: comparisons of local flux predictions in the rat, monkey, and human nasal passages. Toxicol Sci; 64: 100-10.
    • (2001) Toxicol Sci , vol.64 , pp. 100-110
    • Kimbell, J.S.1    Subramaniam, R.P.2    Gross, E.A.3
  • 25
    • 0037214543 scopus 로고    scopus 로고
    • Inhaled formaldehyde: Exposure estimation, hazard characterization, and exposure-response analysis
    • Liteplo RG, Meek ME. (2003) Inhaled formaldehyde: exposure estimation, hazard characterization, and exposure-response analysis. J Toxicol Environ Health B Crit Rev; 6: 85-114.
    • (2003) J Toxicol Environ Health B Crit Rev , vol.6 , pp. 85-114
    • Liteplo, R.G.1    Meek, M.E.2
  • 27
    • 0030724429 scopus 로고    scopus 로고
    • Chemically-induced nasal carcinogenesis and epithelial cell proliferation: A brief review
    • Monticello TM, Morgan KT. (1997) Chemically-induced nasal carcinogenesis and epithelial cell proliferation: a brief review. Mutat Res; 380: 33-41.
    • (1997) Mutat Res , vol.380 , pp. 33-41
    • Monticello, T.M.1    Morgan, K.T.2
  • 28
    • 0026327938 scopus 로고
    • Regional increases in rat nasal epithelial cell proliferation following acute and subchronic inhalation of formaldehyde
    • Monticello TM, Miller FJ, Morgan KT. (1991) Regional increases in rat nasal epithelial cell proliferation following acute and subchronic inhalation of formaldehyde. Toxicol Appl Pharmacol; 111: 409-21.
    • (1991) Toxicol Appl Pharmacol , vol.111 , pp. 409-421
    • Monticello, T.M.1    Miller, F.J.2    Morgan, K.T.3
  • 29
    • 0030020013 scopus 로고    scopus 로고
    • Correlation of regional and nonlinear formaldehyde-induced nasal cancer with proliferating populations of cells
    • Monticello TM, Swenberg JA, Gross EA et al. (1996) Correlation of regional and nonlinear formaldehyde-induced nasal cancer with proliferating populations of cells. Cancer Res; 56: 1012-22.
    • (1996) Cancer Res , vol.56 , pp. 1012-1022
    • Monticello, T.M.1    Swenberg, J.A.2    Gross, E.A.3
  • 30
    • 0019467329 scopus 로고
    • Mutation and cancer: A model for human carcinogenesis
    • Moolgavkar S, Knudson AJ. (1981) Mutation and cancer: a model for human carcinogenesis. J Natl Cancer Inst; 66: 1037-52.
    • (1981) J Natl Cancer Inst , vol.66 , pp. 1037-1052
    • Moolgavkar, S.1    Knudson, A.J.2
  • 31
    • 0026638937 scopus 로고
    • Interpretation of labeling indices in the presence of cell death
    • Moolgavkar SH, Luebeck EG. (1992) Interpretation of labeling indices in the presence of cell death. Carcinogenesis; 13: 1007-10.
    • (1992) Carcinogenesis , vol.13 , pp. 1007-1010
    • Moolgavkar, S.H.1    Luebeck, E.G.2
  • 32
    • 0018537343 scopus 로고
    • Two-event model for carcinogenesis: Incidence curves for childhood and adult tumors
    • Moolgavkar S, Venzon D. (1979) Two-event model for carcinogenesis: incidence curves for childhood and adult tumors. Math Biosci; 47: 55-77.
    • (1979) Math Biosci , vol.47 , pp. 55-77
    • Moolgavkar, S.1    Venzon, D.2
  • 33
    • 0023808155 scopus 로고
    • A stochastic 2-stage model for cancer risk assessment. I. The hazard function and the probability of tumor
    • Moolgavkar SH, Dewanji A, Venzon DJ. (1988) A stochastic 2-stage model for cancer risk assessment. I. The hazard function and the probability of tumor. Risk Anal; 8: 383-92.
    • (1988) Risk Anal , vol.8 , pp. 383-392
    • Moolgavkar, S.H.1    Dewanji, A.2    Venzon, D.J.3
  • 34
    • 0035158879 scopus 로고    scopus 로고
    • Dosimetry modeling of inhaled formaldehyde: The human respiratory tract
    • Overton JH, Kimbell JS, Miller FJ. (2001) Dosimetry modeling of inhaled formaldehyde: the human respiratory tract. Toxicol Sci; 64: 122-34.
    • (2001) Toxicol Sci , vol.64 , pp. 122-134
    • Overton, J.H.1    Kimbell, J.S.2    Miller, F.J.3
  • 35
    • 36849010844 scopus 로고    scopus 로고
    • Incorporating historical control data when comparing tumor incidence rates
    • Peddada S, Dinse G, Kissling G. (2007) Incorporating historical control data when comparing tumor incidence rates. J Am Stat Assoc; 102: 1212-20.
    • (2007) J Am Stat Assoc , vol.102 , pp. 1212-1220
    • Peddada, S.1    Dinse, G.2    Kissling, G.3
  • 36
    • 0023249622 scopus 로고
    • Influence of body weight on the incidence of spontaneous neoplasms in rats and mice of long-term studies
    • Rao GN, Piegorsch WW, Haseman JK. (1987) Influence of body weight on the incidence of spontaneous neoplasms in rats and mice of long-term studies. Am J Clin Nutr; 45: 252-60.
    • (1987) Am J Clin Nutr , vol.45 , pp. 252-260
    • Rao, G.N.1    Piegorsch, W.W.2    Haseman, J.K.3
  • 37
    • 0032611439 scopus 로고    scopus 로고
    • Active cell death (apoptosis) and cellular proliferation as indicators of exposure to carcinogens
    • Schulte-Hermann R, Bursch W, Marian B et al. (1999) Active cell death (apoptosis) and cellular proliferation as indicators of exposure to carcinogens. IARC Sci Publ; 146: 273-85.
    • (1999) IARC Sci Publ , vol.146 , pp. 273-285
    • Schulte-Hermann, R.1    Bursch, W.2    Marian, B.3
  • 38
    • 49449116309 scopus 로고    scopus 로고
    • SEER. (2005) Surveillance, epidemiology, and end results (SEER) program (www.seer.cancer.gov) SEER*Stat database: incidence - SEER 13 regs public-use, Nov 2004 sub for expanded races (1992-2002), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2005, based on the November 2004 submission. Bethesda, MD: National Cancer Institute.
    • SEER. (2005) Surveillance, epidemiology, and end results (SEER) program (www.seer.cancer.gov) SEER*Stat database: incidence - SEER 13 regs public-use, Nov 2004 sub for expanded races (1992-2002), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2005, based on the November 2004 submission. Bethesda, MD: National Cancer Institute.
  • 39
    • 0036001251 scopus 로고    scopus 로고
    • Evaluation of mutagenic effects of formaldehyde in vitro: Detection of crosslinks and mutations in mouse lymphoma cells
    • Speit G, Merk O. (2002) Evaluation of mutagenic effects of formaldehyde in vitro: detection of crosslinks and mutations in mouse lymphoma cells. Mutagenesis; 17: 183-7.
    • (2002) Mutagenesis , vol.17 , pp. 183-187
    • Speit, G.1    Merk, O.2
  • 40
    • 0031889332 scopus 로고    scopus 로고
    • Computational fluid dynamics simulations of inspiratory airflow in the human nose and nasopharynx
    • Subramaniam RP, Richardson RB, Morgan KT et al. (1998) Computational fluid dynamics simulations of inspiratory airflow in the human nose and nasopharynx. Inhal Toxicol; 10: 92-120.
    • (1998) Inhal Toxicol , vol.10 , pp. 92-120
    • Subramaniam, R.P.1    Richardson, R.B.2    Morgan, K.T.3
  • 41
    • 36849031357 scopus 로고    scopus 로고
    • Uncertainties in the CIIT 2-stage model for formaldehyde-induced nasal cancer in the F344 rat: A limited sensitivity analysis - I
    • Subramaniam R, Chen C, Crump K et al. (2007) Uncertainties in the CIIT 2-stage model for formaldehyde-induced nasal cancer in the F344 rat: a limited sensitivity analysis - I. Risk Anal; 27: 1237-54.
    • (2007) Risk Anal , vol.27 , pp. 1237-1254
    • Subramaniam, R.1    Chen, C.2    Crump, K.3
  • 42
    • 48349118361 scopus 로고    scopus 로고
    • Uncertainties in biologically-based modeling of formaldehyde-induced cancer risk: Identification of key issues
    • 18 June, doi: 10.1111/j.1539-6924.2008. 01083.x
    • Subramaniam R, Chen C, Crump K et al. (2008) Uncertainties in biologically-based modeling of formaldehyde-induced cancer risk: identification of key issues. Risk Anal; Accessed 18 June 2008, doi: 10.1111/j.1539-6924.2008. 01083.x.
    • (2008) Risk Anal; Accessed
    • Subramaniam, R.1    Chen, C.2    Crump, K.3
  • 43
    • 0034995659 scopus 로고    scopus 로고
    • Formaldehyde promotes and inhibits the proliferation of cultured tumour and endothelial cells
    • Tyihak E, Bocsi J, Timar F et al. (2001) Formaldehyde promotes and inhibits the proliferation of cultured tumour and endothelial cells. Cell Prolif; 34: 135-41.
    • (2001) Cell Prolif , vol.34 , pp. 135-141
    • Tyihak, E.1    Bocsi, J.2    Timar, F.3
  • 44
    • 49449100998 scopus 로고    scopus 로고
    • USEPA. (2005) Guidelines for carcinogen risk assessment. Washington, DC: United States Environmental Protection Agency EPA/630/P-03/001F.
    • USEPA. (2005) Guidelines for carcinogen risk assessment. Washington, DC: United States Environmental Protection Agency EPA/630/P-03/001F.
  • 46
    • 48349138107 scopus 로고    scopus 로고
    • National Emission Standards for Hazardous Air Pollutants: Plywood and Composite Wood Products; List of Hazardous Air Pollutants, Lesser Quantity Designations, Source Category List; Final Rule. 40 CFR Part 63
    • USEPA
    • USEPA. (2006b) National Emission Standards for Hazardous Air Pollutants: Plywood and Composite Wood Products; List of Hazardous Air Pollutants, Lesser Quantity Designations, Source Category List; Final Rule. 40 CFR Part 63. Federal Reg; 71: 8341-8387.
    • (2006) Federal Reg , vol.71 , pp. 8341-8387


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.