Time course investigation of intervertebral disc degeneration produced by needle-stab injury of the rat caudal spine: Laboratory investigation

Journal of Neurosurgery: Spine

Volumn 15, Issue 4, 2011, Pages 404-413

  Zhang, Huina ^a,b   Yang, Sushan ^b   Wang, Lin ^a   Park, Paul ^a   La Marca, Frank ^a   Holl Ister, Scott J ^b   Lin, Chia Ying ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Caudal spine; Intervertebral disc degeneration; Needle puncture; Trauma

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; GLYCOSAMINOGLYCAN; MESSENGER RNA; STROMELYSIN;

AGGRECAN GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BMP 2 GENE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; FLUOROSCOPY; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HISTOLOGY; IN VIVO STUDY; INTERVERTEBRAL DISK DEGENERATION; MALE; MMP 3 GENE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PUNCTURE; RAT; STAB WOUND; TYPE I COLLAGEN GENE; TYPE II COLLAGEN GENE; UPREGULATION;

AGGRECANS; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE II; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; MALE; RATS; RATS, SPRAGUE-DAWLEY; SPINAL DISEASES; UP-REGULATION;

EID: 80053445203     PISSN: 15475654     EISSN: 15475646     Source Type: Journal    
DOI: 10.3171/2011.5.SPINE10811     Document Type: Article

References (30)

1. Adler JH, Schoenbaum M, Silberberg R: Early onset of disk degeneration and spondylosis in sand rats (Psammomys obesus). Vet Pathol 20:13-22, 1983 (Pubitemid 13145628)
2. Chandrasekhar S, Esterman MA, Hoffman HA: Microdetermination of proteoglycans and glycosaminoglycans in the presence of guanidine hydrochloride. Anal Biochem 161:103-108, 1987 (Pubitemid 17036695)
3. Chubinskaya S, Kawakami M, Rappoport L, Matsumoto T, Migita N, Rueger DC: Anti-catabolic effect of OP-1 in chronically compressed intervertebral discs. J Orthop Res 25:517-530, 2007 (Pubitemid 46542040)
4. Gruber HE, Johnson T, Norton HJ, Hanley EN Jr: The sand rat model for disc degeneration: radiologic characterization of age-related changes: cross-sectional and prospective analyses. Spine (Phila Pa 1976) 27:230-234, 2002
5. Han B, Zhu K, Li FC, Xiao YX, Feng J, Shi ZL, et al: A simple disc degeneration model induced by percutaneous needle puncture in the rat tail. Spine (Phila Pa 1976) 33:1925-1934, 2008
6. Hoogendoorn RJ, Helder MN, Kroeze RJ, Bank RA, Smit TH, Wuisman PI: Reproducible long-term disc degeneration in a large animal model. Spine (Phila Pa 1976) 33:949-954, 2008
7. Hoogendoorn RJ, Wuisman PI, Smit TH, Everts VE, Helder MN: Experimental intervertebral disc degeneration induced by chondroitinase ABC in the goat. Spine (Phila Pa 1976) 32:1816-1825, 2007
8. Iatridis JC, Mente PL, Stokes IA, Aronsson DD, Alini M: Compression-induced changes in intervertebral disc properties in a rat tail model. Spine (Phila Pa 1976) 24:996-1002, 1999
9. Imai Y, Miyamoto K, An HS, Thonar EJ, Andersson GB, Masuda K: Recombinant human osteogenic protein-1 upregulates proteoglycan metabolism of human anulus fibrosus and nucleus pulposus cells. Spine (Phila Pa 1976) 32:1303-1310, 2007
10. Kim YJ, Sah RL, Doong JY, Grodzinsky AJ: Fluorometric assay of DNA in cartilage explants using Hoechst 33258. Anal Biochem 174:168-176, 1988 (Pubitemid 18261664)
11. Kroeber MW, Unglaub F, Wang H, Schmid C, Thomsen M, Nerlich A, et al: New in vivo animal model to create intervertebral disc degeneration and to investigate the effects of therapeutic strategies to stimulate disc regeneration. Spine (Phila Pa 1976) 27:2684-2690, 2002
12. Li CG, Liang QQ, Zhou Q, Menga E, Cui XJ, Shu B, et al: A continuous observation of the degenerative process in the intervertebral disc of Smad3 gene knock-out mice. Spine (Phila Pa 1976) 34:1363-1369, 2009
13. Li J, Yoon ST, Hutton WC: Effect of bone morphogenetic protein- 2 (BMP-2) on matrix production, other BMPs, and BMP receptors in rat intervertebral disc cells. J Spinal Disord Tech 17:423-428, 2004 (Pubitemid 43020807)
14. Lipson SJ, Muir H: 1980 Volvo award in basic science. Proteoglycans in experimental intervertebral disc degeneration. Spine (Phila Pa 1976) 6:194-210, 1981
15. Lotz JC, Ulrich JA: Innervation, inflammation, and hypermobility may characterize pathologic disc degeneration: review of animal model data. J Bone Joint Surg Am 88 (Suppl 2):76-82, 2006
16. Masuda K, Aota Y, Muehleman C, Imai Y, Okuma M, Thonar EJ, et al: A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration. Spine (Phila Pa 1976) 30:5-14, 2005
17. Masuda K, Imai Y, Okuma M, Muehleman C, Nakagawa K, Akeda K, et al: Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model. Spine (Phila Pa 1976) 31:742-754, 2006
18. Miller JA, Schmatz C, Schultz AB: Lumbar disc degeneration: correlation with age, sex, and spine level in 600 autopsy specimens. Spine (Phila Pa 1976) 13:173-178, 1988
19. Moskowitz RW, Ziv I, Denko CW, Boja B, Jones PK, Adler JH: Spondylosis in sand rats: a model of intervertebral disc degeneration and hyperostosis. J Orthop Res 8:401-411, 1990 (Pubitemid 20250863)
20. Nemoto O, Yamagishi M, Yamada H, Kikuchi T, Takaishi H: Matrix metalloproteinase-3 production by human degenerated intervertebral disc. J Spinal Disord 10:493-498, 1997 (Pubitemid 28012007)
21. Nerlich AG, Schleicher ED, Boos N: 1997 Volvo Award winner in basic science studies. Immunohistologic markers for age-related changes of human lumbar intervertebral discs. Spine (Phila Pa 1976) 22:2781-2795, 1997
22. Oda H, Matsuzaki H, Tokuhashi Y, Wakabayashi K, Uematsu Y, Iwahashi M: Degeneration of intervertebral discs due to smoking: experimental assessment in a rat-smoking model. J Orthop Sci 9:135-141, 2004 (Pubitemid 38506737)
23. Omlor GW, Lorenz H, Engelleiter K, Richter W, Carstens C, Kroeber MW, et al: Changes in gene expression and protein distribution at different stages of mechanically induced disc degeneration - an in vivo study on the New Zealand white rabbit. J Orthop Res 24:385-392, 2006 (Pubitemid 43772999)
24. Rousseau MA, Ulrich JA, Bass EC, Rodriguez AG, Liu JJ, Lotz JC: Stab incision for inducing intervertebral disc degeneration in the rat. Spine (Phila Pa 1976) 32:17-24, 2007
25. Sobajima S, Kompel JF, Kim JS, Wallach CJ, Robertson DD, Vogt MT, et al: A slowly progressive and reproducible animal model of intervertebral disc degeneration characterized by MRI, X-ray, and histology. Spine (Phila Pa 1976) 30:15-24, 2005
26. Sobajima S, Shimer AL, Chadderdon RC, Kompel JF, Kim JS, Gilbertson LG, et al: Quantitative analysis of gene expression in a rabbit model of intervertebral disc degeneration by real-time polymerase chain reaction. Spine J 5:14-23, 2005 (Pubitemid 40104285)
27. Ulrich JA, Liebenberg EC, Thuillier DU, Lotz JC. ISSLS prize winner: repeated disc injury causes persistent inflammation. Spine (Phila Pa 1976) 32:2812-2819, 2007
28. Urban JP, Roberts S: Degeneration of the intervertebral disc. Arthritis Res Ther 5:120-130, 2003 (Pubitemid 36849758)
29. Yoon SH, Miyazaki M, Hong SW, Tow B, Morishita Y, Hu M, et al: A porcine model of intervertebral disc degeneration induced by annular injury characterized with magnetic resonance imaging and histopathological findings. Laboratory investigation. J Neurosurg Spine 8:450-457, 2008 (Pubitemid 351792087)
30. Zhang H, La Marca F, Hollister SJ, Goldstein SA, Lin CY: Developing consistently reproducible intervertebral disc degeneration at rat caudal spine by using needle puncture. Laboratory investigation. J Neurosurg Spine 10:522-530, 2009